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New device aims to help ventilator patients breathe easier by scrubbing CO2 from blood

NCT ID NCT07326215

Recruiting now Disease control Sponsor: Vantive Health LLC Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a device called PrismaLung+ that removes carbon dioxide from the blood of critically ill patients who are on breathing machines. The trial will include 99 adults with acute respiratory distress syndrome or kidney injury. Half will receive standard care plus the device, while the other half gets standard care alone. The goal is to see if the device safely lowers carbon dioxide levels and improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PrismaLung+ device (extracorporeal carbon dioxide removal system)
What this could lead to
If successful, this device could help critically ill patients on ventilators by safely lowering carbon dioxide levels, potentially reducing lung damage and improving recovery.
What could go wrong
This is an early-stage trial with only 99 participants, so results may not apply to all patients. The device requires blood thinning, which carries bleeding risks.

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Conditions

The condition(s) this trial relates to.

acute kidney injury acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY ACUTE RESPIRATORY DISTRESS SYNDROME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • China-Japan Friendship Hospital

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100029, China

    Contact

  • Sichuan Provincial People's Hospital

    NOT_YET_RECRUITING

    Chengdu, Sichuan, 610072, China

    Contact

  • Sir Run Run Shaw Hospital Zhejiang University School of Medicine

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310016, China

    Contact

  • The First Affiliated Hospital Zhejiang University School of Medicine

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, 310003, China

    Contact

  • The First Affiliated Hospital of Guangzhou Medical University

    NOT_YET_RECRUITING

    Guangzhou, Guangdong, 510630, China

    Contact

  • The First Affiliated Hospital of Harbin Medical University

    NOT_YET_RECRUITING

    Harbin, Heilongjiang, 150001, China

    Contact

  • The First Affiliated Hospital of Nanchang University

    NOT_YET_RECRUITING

    Nanchang, Jiangxi, 330006, China

    Contact

  • The University of Hong Kong-Shenzhen Hospital

    NOT_YET_RECRUITING

    Shenzhen, Guangdong, 518053, China

    Contact

  • ZhongShan Hospital Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

    Contact

  • Zhongda Hospital Southeast University

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, 210009, China

    Contact

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