ICU kidney trial aims to find best fluid removal rate

NCT ID NCT05817539

Recruiting now Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two approaches to removing excess fluid in intensive care patients with acute kidney injury who are on dialysis. One group will have fluid removed at a moderate rate to actively reduce fluid buildup, while the other group will have fluid removed slowly to just maintain current levels. The goal is to see which strategy leads to fewer days on life support and better recovery. The trial plans to enroll 250 adults in the ICU.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ultrafiltration (fluid removal) procedure
What this could lead to: If successful, this could establish a safer, more effective way to remove excess fluid in ICU patients on dialysis, potentially reducing time on life support and improving survival.
What could go wrong: This is a moderate-sized early-stage trial, so results may not apply to all ICU patients. Aggressive fluid removal can cause low blood pressure or organ injury, and the benefit over standard care is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute kidney injury Edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY FLUID OVERLOAD

Contacts and locations

Locations

CHU Amiens-Picardie
NOT_YET_RECRUITING

Amiens, 80480, France
CHU Caen Normandie
NOT_YET_RECRUITING

Caen, 14033, France
CHU Lille - Hôpital Roger Salengro
NOT_YET_RECRUITING

Lille, 59037, France
Centre Hospitalier d'Ajaccio
NOT_YET_RECRUITING

Ajaccio, 20090, France
Département d'anesthésie réanimation Hôpital Européen Georges Pompidou
RECRUITING

Paris, 75015, France
GHP Saint Joseph Marie Lannelongue
NOT_YET_RECRUITING

Le Plessis-Robinson, 92350, France
Hôpital Edouard Herriot
NOT_YET_RECRUITING

Lyon, 69437, France
Hôpital Edouard Herriot, Groupement Hospitalier Centre
RECRUITING

Lyon, 69003, France
Hôpital de la Croix Rousse
NOT_YET_RECRUITING

Lyon, 69004, France
Hôpital de la Croix Rousse
RECRUITING

Lyon, 69004, France
Hôpitaux de Bradois - CHRU Nancy
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Service d'Anesthesie-Réanimation, Hôpital Louis Pradel, Hospices Civils de Lyon
RECRUITING

Bron, 69500, France
Service de Réanimation, CHU de Dijon
RECRUITING

Dijon, 21000, France
Service de Réanimation, Clinique de la Sauvegarde
RECRUITING

Lyon, 69009, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.