Creatine supplement may shield kidneys and mind during hot workouts

NCT ID NCT07472426

Recruiting now Knowledge-focused Sponsor: University of Northern Iowa Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether taking creatine for a week can reduce kidney injury and keep thinking sharp during exercise in the heat. Twenty healthy, active adults will cycle in a hot room after taking creatine or a placebo. Researchers will measure urine markers of kidney stress and test cognitive performance before and after exercise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: creatine monohydrate
What this could lead to: If it works, this could point toward a way to protect kidneys and thinking during intense exercise in hot conditions.
What could go wrong: This is a very small, early study in healthy volunteers, not patients. Results may not apply to real-world kidney injury or heat illness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury exercise-induced malignant hyperthermia Heat Stress Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY EXERTIONAL HEAT ILLNESS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Wellness and Recreation Center
RECRUITING

Cedar Falls, Iowa, 50614, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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