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Creatine supplement may shield kidneys and mind during hot workouts

NCT ID NCT07472426

Knowledge-focused Sponsor: University of Northern Iowa Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether taking creatine for a week can reduce kidney injury and keep thinking sharp during exercise in the heat. Twenty healthy, active adults will cycle in a hot room after taking creatine or a placebo. Researchers will measure urine markers of kidney stress and test cognitive performance before and after exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
creatine monohydrate
What this could lead to
If it works, this could point toward a way to protect kidneys and thinking during intense exercise in hot conditions.
What could go wrong
This is a very small, early study in healthy volunteers, not patients. Results may not apply to real-world kidney injury or heat illness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age range: 18-45 years old * Physical Activity Level: Classified as 'active' using the criteria of engaging in planned exercise at least 3x/week, for a minimum of 30 minutes per session, over the past 3 months * Aerobic Fitness Level: Subjects must have an aerobic fitness classification of at least 'good' per American College of Sports Medicine (ACSM) criteria and assessed via maximal oxygen uptake test * Health Status: Free of any known cardiovascular, metabolic, renal, or neurologic conditions. * Physical Limitations: Indicates no physical limitations to cycling for \~ 90 minutes * Supplementation: Reports no use of creatine within the past 4 weeks * Recent Illness: Reports no presence of illness, vomiting, or diarrhea in the previous three days. Exclusion Criteria: * Known allergy to creatine or maltodextrin. * History of adverse heat-related events (e.g., heat exhaustion, heat stroke, severe dehydration requiring medical intervention) * Reports use of medications or supplements that may interfere with thermoregulation, heart rate, kidney injury or blood pressure responses during exercise (e.g. NSAID)

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Conditions

The condition(s) this trial relates to.

acute kidney injury exercise-induced malignant hyperthermia Heat Stress Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Exertional heat illness

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Wellness and Recreation Center

    RECRUITING

    Cedar Falls, Iowa, 50614, United States

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