CANCER

This early-stage study is testing a new oral medication called HBI-2376 in people with advanced solid tumors that have specific KRAS or EGFR mutations. The main goals are to find the highest safe dose of the drug and to understand how the body absorbs and processes it. The trial …

This early-stage study is testing a new cell-based immunotherapy called ACIT-1 in adults with cancer. The main goals are to find the safest dose and see if the treatment can help the patient's own immune system recognize and attack cancer cells. About half of the participants wil…

This is an early-stage safety study testing a new treatment called RP2, which is a genetically modified cold sore virus designed to kill cancer cells and boost the immune system. It is being given alone and in combination with an existing immunotherapy drug (nivolumab) to adults …

This study aims to understand the best way to treat cancer patients whose cancer has spread to their thigh bone, putting them at high risk of a fracture. It follows 180 patients who receive either surgery (with or without radiation) or radiation therapy alone. Researchers will tr…

This study aimed to see if giving two cancer drugs before surgery could help the immune system attack specific types of soft tissue sarcoma tumors. It focused on adults with two rare sarcoma types that had a specific immune cell pattern. The goal was to shrink tumors before remov…

This study is testing a new way to give standard chemotherapy (R-CHOP) to older adults with an aggressive type of lymphoma called DLBCL. The goal is to split the doses over two weeks instead of giving them all at once, which researchers hope will be easier for older patients to t…

This study allows cancer patients who were already taking osimertinib in a previous trial and are still benefiting from it to continue receiving the medication. It tracks safety and side effects while patients keep taking the drug. The goal is to provide continued access to treat…

This study is testing whether a newer immunotherapy drug (pembrolizumab) combined with radiation works better than the current standard treatment of chemotherapy plus radiation for people with advanced head and neck cancer. It will involve 126 patients whose cancer is linked to t…

This study is testing a personalized vaccine designed to teach a patient's own immune system to recognize and attack their specific cancer. It is for people with certain solid tumors, including pancreatic cancer and glioblastoma, who have limited treatment options. The main goals…

This is the first human study of an experimental oral medication called HBI-2438 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find the highest safe dose and understand how the body processes the drug. The study …

This study will monitor 60 people for 15 years after they received an experimental cancer treatment called SynKIR CAR T-cell therapy. The main goal is to check for any long-term side effects and see how well the treatment continues to work over time. No new treatment is given in …

This study allows cancer patients who are still benefiting from durvalumab treatment in a previous trial to continue receiving it. It's designed for 214 patients who have completed their original study but need ongoing treatment. The main goal is to monitor safety while providing…

This study tests a new program designed to improve teamwork between cancer specialists and primary care doctors (PCPs) for patients who have both cancer and a heart-related condition like high blood pressure or diabetes. The goal is to see if better coordination helps manage the …

This study allows cancer patients who were benefiting from atezolizumab treatment in previous Roche-sponsored trials to continue receiving their therapy. It's designed for patients who don't have access to this treatment through regular commercial channels in their country. The s…

This study is exploring whether fasting for 24 hours before and after chemotherapy is safe, practical, and acceptable for people with Hodgkin or Diffuse Large B-Cell Lymphoma. Researchers will compare 40 patients who fast to those who follow standard care, tracking side effects, …

This study is testing a new type of radiation machine that combines an MRI scanner with a radiation beam. The goal is to see if using real-time MRI images to guide and adjust radiation treatment can help doctors target cancer more precisely, improve survival, and reduce side effe…

This study is testing whether a combination of four oral medications can shrink tumors in children whose cancer has returned or did not respond to standard treatments. It focuses on solid tumors and brain tumors. The main goal is to see if this drug regimen is effective at contro…

This study is testing a personalized care plan designed to help older adults with cancer better handle chemotherapy. The plan uses a questionnaire to identify individual health risks and then suggests specific support, like nutrition advice or physical therapy. Researchers want t…

This early-stage study is testing a new drug called RNDO-564, both by itself and combined with an existing immunotherapy (pembrolizumab), in adults with advanced cancers that have stopped responding to standard treatments. The main goals are to find safe doses and see how the bod…

This study allows patients already receiving venetoclax in other trials to continue treatment if they are benefiting and tolerating it well. The main goal is to collect long-term safety information by tracking any side effects. It includes about 165 patients with various blood ca…

This study is testing a new clinic program called ActivityChoice, designed to help cancer survivors start and maintain physical activity. The goal is to lower their risk of heart disease, which is a leading cause of death for survivors. The program uses simple stories and tools t…

This study aims to understand if providing hospital-level cancer care at home is practical and safe. Researchers will follow 40 cancer patients enrolled in a home care program to see if they need to return to the hospital and how they feel about the experience. The goal is to gat…

This early study is testing a new way to treat prostate cancer by delivering tiny radioactive glass beads directly into the tumor's blood supply. The goal is to find the safest and most effective dose of this targeted radiation therapy for men with localized prostate cancer who h…

This study is testing if a structured checklist can help coordinate cancer care services as effectively as traditional one-on-one support. It involves 600 Chinese adults in specific Chicago neighborhoods. The goal is to see if the checklist helps people get recommended cancer scr…

This study allows cancer patients who were benefiting from atezolizumab treatment in previous Roche-sponsored trials to continue receiving their medication after those trials close. The research monitors 382 participants to track long-term safety and survival outcomes while provi…

This trial is testing whether a targeted radiation therapy that works for prostate cancer might also help people with other advanced cancers. The treatment uses a radioactive drug that seeks out and attaches to a specific marker (PSMA) found on some cancer cells or their blood ve…

This study is testing whether a simple online tool can help elderly cancer patients report their symptoms from home. Patients answer weekly questions on a phone or tablet, and the system alerts their medical team if serious problems arise. The goal is to see if this remote monito…

This study is testing whether a combination of two immunotherapy drugs, atezolizumab and tiragolumab, can help control cancer of unknown primary. It is for adults whose cancer has spread and who have already tried or cannot have standard chemotherapy. The main goals are to see if…

This study aims to find better ways to check for heart damage in adults who have finished chemotherapy for cancer. Researchers are testing if a simple AI analysis of a heart tracing (ECG) or a blood test can reliably detect a weakened heart pump. The goal is to gather data to pla…

This early-stage study is testing a new radioactive tracer called [18F]-C-SNAT4 for PET scans. The goal is to see if this tracer can safely and effectively help doctors better see and monitor lung cancer. The study will involve 20 people, including healthy volunteers and patients…

This study is testing two different ways to help women who had chest radiation as children get recommended breast cancer screenings. Researchers want to see if personalized mailings and phone coaching are more effective than standard information at getting women to complete mammo…

This study tests whether group education sessions can help women with BRCA gene mutations follow recommended cancer screening and prevention procedures. The program focuses on medically underserved women and racial/ethnic minorities who carry these high-risk genes. Researchers wi…

This study is testing how well a family wellness program called Turtle Island Tales can reach American Indian families to help prevent childhood obesity and related cancers. The program uses cultural stories and activities to promote healthy eating, physical activity, and family …

This study offers an experimental procedure to freeze ovarian tissue from girls (newborn to 17 years old) who face medical treatments like chemotherapy that could leave them infertile. The goal is to preserve the tissue so it might be used in the future to help them get pregnant …

This study aims to understand why some African American women don't exercise often and to test if learning to support a partner's exercise habits can help them become more active. Researchers will enroll 80 sedentary women and their female friends or family members. One group wil…

This study is testing whether switching to a whole-food, plant-based diet can help lower markers linked to cancer risk in firefighters. For 12 weeks, 120 active San Francisco firefighters will either follow this special diet or eat their usual meals. Researchers will measure chan…

This large study aimed to find out if taking daily vitamin D or fish oil (omega-3) supplements could help prevent cancer, heart attacks, and strokes in healthy people. Over 25,000 older U.S. adults without prior cancer or heart disease were randomly assigned to take either the re…

This study aimed to see if regular clinic visits and a pneumonia vaccine could help prevent infections in cancer patients after they received CAR-T cell therapy. The plan was to enroll 50 adults with blood cancers or solid tumors who were getting this specialized treatment. Resea…

This small pilot study is testing whether electroacupuncture—a form of acupuncture with mild electrical stimulation—is a practical and helpful way to manage difficult symptoms after a major abdominal cancer surgery. The study will enroll 20 patients who have undergone this specif…

This study is testing whether a form of acupuncture with mild electrical stimulation can help manage common symptoms in people with cancer or cancer survivors. 70 participants will receive either real or 'sham' electroacupuncture over 10 weeks to see if it eases fatigue, memory p…

This study is testing whether a home-based light therapy device, used alongside computer brain training games, can help improve memory, attention, and thinking skills in adult survivors of childhood leukemia or Hodgkin's lymphoma. Participants use the device at home three times a…

This study aims to see if mind-body therapies like mindfulness, laughter yoga, or art therapy can improve the quality of life and reduce emotional distress for people living with cancer. It will follow 150 patients who choose to participate in one of these therapy programs at spe…

This study aims to see if automatically referring cancer patients to palliative care during emergency room visits leads to less aggressive medical treatments at the end of life and better quality of life. It will involve 240 adult cancer patients in France whose disease is not cu…

This study is developing and testing a culturally adapted meditation and support program specifically for Black patients with advanced cancer. Researchers will first gather input from patients and caregivers to shape the program, then pilot test it against a standard education pr…

This study is testing two different approaches to managing symptoms for cancer patients receiving palliative care. Researchers want to see which method better improves patients' quality of life and reduces their symptoms. The study involves 208 adult cancer patients in Pennsylvan…

This study tests different ways to help cancer patients struggling with the high costs of care and basic needs like food and housing. It compares three approaches: one-on-one financial counseling, providing self-help resource lists, and standard care. The goal is to see which met…

This study is testing whether a free phone app called OnKO-Tips&Tricks can improve the quality of life for teens and young adults (ages 15-25) being treated for cancer. The app provides daily check-ins, connects users directly with their nurse coordinator, and offers educational …

This study looked at whether a supervised group exercise program in local communities helps adults with cancer. Nearly 500 participants, including those in treatment and survivors, joined aerobic and strength training sessions in-person or online for one year. Researchers measure…

This study aimed to see if a patient's mindset about their cancer and body could affect their treatment experience and quality of life. It planned to test a brief educational session designed to foster helpful mindsets in newly diagnosed patients. The goal was to see if this simp…

This study is testing whether adding a community health worker to standard care improves quality of life for African American patients with advanced cancer. Researchers will compare outcomes between patients receiving standard care alone and those who also get support from a trai…

This study is testing a web-based support program designed to help advanced cancer patients manage symptoms like depression, pain, and fatigue. It also aims to reduce stress and depression in their spouses or partners who are providing care. The program is intended to be accessib…

This study is testing whether a tablet-based symptom management program can help people with advanced cancer who live in rural areas. Participants are randomly assigned to either use the 'Nurse AMIE' app or receive a supportive care book. The main goal is to see if using the app …

This small pilot study aims to see if chiropractic care is a practical and helpful way to reduce severe, long-lasting fatigue in adults who have finished their cancer treatment. Researchers will enroll 40 cancer survivors to test if the treatment is feasible and well-tolerated. T…

This study is testing whether a combined mobile exercise and memory training program is practical and helpful for older cancer survivors who have completed treatment. It aims to see if this approach can improve thinking and memory problems that sometimes occur after cancer therap…

This study tests whether an educational video helps cancer patients better understand and use palliative care services. Adults with serious cancer diagnoses in Louisiana will watch the video and receive materials about palliative care. Researchers will track whether patients use …

This study is testing a new therapy designed to help breast cancer survivors manage anxiety. The therapy teaches people to better notice and understand their own bodily signals, like their heartbeat. Researchers want to see if this approach is practical and acceptable for 20 surv…

This study is testing whether a simple, non-drug option—a cooling mat—can help reduce hot flashes and night sweats in people receiving hormone therapy for breast or prostate cancer. The pilot study will enroll 40 participants to see if using the mat for 8 weeks is practical and i…

This study is testing a digital program called EMBody, which uses short films and activities, to see if it can improve the quality of life for young people aged 16-25 who have finished cancer treatment. The program, co-created with survivors and doctors, aims to help them develop…

This study is testing whether a mobile health program can help young adult cancer survivors become more physically active. Researchers are enrolling about 320 survivors in Alberta who finished cancer treatment within the last year. One group will receive a personalized activity p…

This small, early-stage study is testing whether taking kava, a plant-based supplement, can safely help reduce anxiety and stress in people who have finished cancer treatment. Participants take either kava or a placebo pill for two weeks, then switch after a break. The study is c…

This study tests a 12-week lifestyle program designed to help Hispanic female cancer survivors and their caregivers. The program focuses on improving diet and physical activity to reduce common, lingering symptoms like pain, fatigue, and anxiety. Researchers are measuring if thes…

This study is testing whether a peer-led group program can help cancer survivors manage feelings of anxiety and depression after finishing their main cancer treatment. The program involves seven weekly group sessions led by trained non-professionals, focusing on building skills t…

This study is testing a 12-week smartphone program designed to help young adult cancer survivors become more physically active. Researchers are comparing different features, like having a support buddy, a coach, or mindfulness training, to see which ones work best. The goal is to…

This study is testing a training program called CASCADE for family members who help make medical decisions for a loved one with newly diagnosed advanced cancer. The program uses nurse coaches to teach communication and decision-support skills over phone calls. Researchers want to…

This study is testing whether connecting patients with a palliative care team before cancer surgery improves their experience. The team helps manage pain, fatigue, anxiety, and emotional distress. Researchers are comparing this early support to usual surgical care to see which le…

This study is testing whether a supervised exercise program can help reduce chronic nerve pain in older Veterans who have survived lung cancer. The goal is to see if physical activity can provide relief without relying as much on strong pain medications like opioids. Researchers …

This study is testing whether a pickleball program is a practical and well-liked way to help cancer survivors and their friends or family get more active and improve their overall wellness. Researchers are enrolling 28 participants to learn and play pickleball together. The main …

This study aims to understand how cancer treatment affects children's muscle mass, physical strength, and aging markers. Researchers will measure 28 children ages 8-21 at diagnosis, during treatment, and after treatment using simple tests and routine scans. The goal is to learn h…

This study is testing a new way for cancer patients to report their symptoms, like pain and fatigue, using a friendly, animated AI chatbot. The goal is to see if this conversational computer character helps patients complete their surveys more thoroughly than using a standard web…

This study is observing over 19,000 older adults who previously participated in an aspirin trial to see if there are any delayed health effects years after stopping the medication. Researchers are primarily watching for long-term impacts on cancer, dementia, heart disease, and ph…

This study aims to understand how radiation therapy for cancer affects the body by collecting blood and urine samples from patients. Researchers will analyze these samples to see changes in genes, cells, and hormones. The goal is to gather knowledge, not to provide a new treatmen…

This study aimed to test if adding visual information pages to consent forms improves the experience for cancer patients considering clinical trials. It measured patient knowledge, anxiety, and trust before and after the visual aids were used. The study was withdrawn before any p…

This study is testing whether it's practical to use a Fitbit activity tracker and a continuous glucose monitor together to track daily exercise patterns. It involves 35 adults who are either cancer survivors or at risk for diabetes but do not have diabetes. The main goal is to se…

This study is observing over 14,000 people who have chosen to take the Galleri blood test for early cancer detection in their regular doctor's offices. The goal is to learn how the test performs and is used in real-world medical practice, not in a controlled trial. Researchers wi…

This study tests whether sharing important genetic health risk information through a secure website is as effective as sharing it through a phone call with a genetic counselor. Researchers will enroll 2,500 people who previously donated samples to a biobank and have a genetic res…

This study is testing whether summaries created by an artificial intelligence (AI) program can help doctors and patients with advanced cancer have better conversations about serious care goals. The AI reviews past medical records to create a summary of what's important to the pat…

This study aims to understand how the immune system in the gut changes when people receive immunotherapy for cancer. Researchers will collect small tissue samples from the lower intestine and blood samples from 38 participants before and during their cancer treatment. The goal is…

This study is looking at how two different diets affect the community of bacteria living in people's guts. Researchers provided all meals for 28 days to 115 healthy Black and White adults in Alabama, comparing the DASH diet to a typical American diet. They collected stool samples…

This study aims to see if a blood test (liquid biopsy) works as well as or better than a standard tissue biopsy to find genetic changes in advanced cancer that can guide treatment. Researchers will compare the two methods in 1,500 patients to see which one finds more actionable t…

This large, long-term study aims to find out if regular screening for prostate, lung, colorectal, and ovarian cancers helps people live longer. It enrolled about 154,900 men and women aged 55 to 74, randomly assigning half to receive screening tests and half to receive their usua…

This study is tracking the long-term health of over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill or lived nearby. Researchers are comparing the health of workers who had direct exposure to oil and chemicals with those who did not, to understand if the sp…

This is a very early study to check if a new cancer drug called AZD6244, given as a capsule, is safe and how it moves through the body. It involved 58 adults with advanced solid tumors that had not responded to standard treatments. The main goal was to find the right dose and und…

This study aims to understand why heart disease, cancer, and other chronic illnesses are rising across Africa by analyzing health data from up to one million adults. Researchers are gathering detailed information about people's health, lifestyle, and environment to identify key r…

This study aims to develop better MRI scanning methods specifically for radiation therapy in cancer patients. Researchers will work with 295 participants, including both cancer patients and healthy volunteers, to improve image quality and test new treatment planning software. The…

This study aims to see if it's practical to track memory and concentration in adults aged 65 and older who are starting a new type of cancer treatment called immune checkpoint inhibitors. About 30 participants will take memory tests every six weeks for six months. The main goal i…

This study aims to understand how certain advanced cancers change during treatment. Researchers will collect blood and tumor samples from 39 patients with specific types of recurrent or metastatic squamous cell cancers (head/neck, esophagus, anal canal) who are starting chemother…

This National Cancer Institute (NCI) study provides standard cancer care and follow-up to patients who need treatment at the NIH but are not in an active research trial. It aims to collect medical information from up to 10,000 participants to help generate ideas for future cancer…

This study aims to understand why some families get cancer more often than others. Researchers are following over 5,000 people from families with unusual patterns of cancer to learn about the roles of genetics and environment. Participants provide health information and samples, …

This pilot study aimed to test a new imaging method to see if it could help predict how well patients with solid tumors respond to antibody-based therapies. Participants would have received a special imaging tracer and a PET/CT scan before starting their standard treatment. The g…

This study is testing a special health assessment tool designed to improve conversations between doctors, older cancer patients (65+), and their caregivers. The goal is to make sure doctors better understand and address age-related concerns when planning chemotherapy. Researchers…

This study aims to understand why some cancer patients experience severe or unexpected side effects from their medications. Researchers will collect blood samples from up to 100 patients already enrolled in other NIH cancer trials who are having these bad reactions. By measuring …

This study is testing a new online health survey called CHAMP, designed for older adults with cancer. The goal is to see if patients can easily complete the survey and if the results help their doctors make more personalized treatment decisions. Researchers are checking if using …

This study aimed to look back at past medical records to see if people diagnosed with lymphoma were more likely to also be diagnosed with another type of cancer at the same time. Researchers planned to analyze data from 2007 to 2012 to understand how often this happens and descri…

This study looks at how cancer doctors use telehealth (video or phone visits) instead of in-person appointments during COVID-19. Researchers want to understand doctors' experiences with telehealth and whether it affects how often patients need emergency care. They'll compare resu…

This study looks at how the COVID-19 pandemic changed the number of people diagnosed with cancer in Bavaria, Germany. Researchers are analyzing cancer registry data from 2018 to 2023 to see if fewer cancers were found during the pandemic, especially in certain areas or for cancer…

This study aims to collect and store biological samples from 500 people with obesity. The goal is to build a repository of blood, urine, and tissue to help researchers understand why weight loss treatments sometimes work or fail, and why weight is often regained. This is an obser…

This study aims to learn how well COVID-19 vaccines protect children and young adults under 24 who have cancer or have received a transplant or cellular therapy. Researchers will measure the strength and duration of the immune response in these vulnerable patients by taking small…

This study is testing whether frozen testicular tissue can be transplanted back into men to restore sperm production. Five healthy adult men who already have children will have small tissue samples frozen during routine surgery, then transplanted back under their skin months late…

This study aims to better understand how radiation therapy affects older adults with cancer. Researchers are following 150 patients aged 65 and older to track their ability to complete treatment, changes in daily function, and side effects. By collecting survey and assessment dat…

This study aims to understand and improve how community cancer clinics screen patients for health-related social needs, such as housing, food, or transportation. It involves observing clinic processes and interviewing staff and patients to identify what helps or hinders these scr…

This study aims to find better ways for doctors to talk with seriously ill patients about their end-of-life care preferences. It will test different communication strategies with 5,000 Duke Health patients who have conditions like cancer, heart failure, COPD, or dementia. The goa…

This study is testing a support program to help rural hospitals in Iowa improve the quality of their cancer care. Researchers are working with staff from five hospitals, providing training and resources to help them meet national cancer care standards. The goal is to see if this …

This project aims to create clear, standard definitions for how cancer clinical trials measure patient outcomes like survival time. It gathers expert opinions to develop guidelines so that future studies can be compared fairly. The goal is to improve the quality and reliability o…

This study aims to understand how cancer affects the identity, relationships, and emotional needs of young survivors. Researchers are interviewing 300 survivors aged 15-25 who finished treatment at least 6 months ago. The goal is to use this information to provide better care and…

This study aims to create a detailed map of the supportive tissue, or 'stroma,' inside different types of tumors, both benign and cancerous. Researchers will analyze tissue samples from 7,000 patients to count different cell types and measure tissue components. The goal is to bui…

This study aims to understand how cancer patients use cannabis and CBD products. Researchers are surveying 100 patients at a pain clinic to learn how often they use it, why they use it (like for pain or other symptoms), and where they get their information. The goal is to gather …

This study aims to find signs in the blood that might predict which cancer patients will experience serious side effects from a newer type of drug called immune checkpoint inhibitors. It involves 69 adults with metastatic cancer who are starting either this immunotherapy or stand…

This study aims to help doctors choose cancer treatments by testing drugs on lab-grown versions of patients' own tumors. Researchers take leftover tissue from routine biopsies or surgeries and grow it in special laboratory mice. They then test multiple anti-cancer drugs on these …

This study aims to understand if certain proteins in the blood (IGF-1 and IGF-1Ec) are linked to how much cancer is in the body. Researchers will analyze blood samples from about 100 adults with solid tumors to see if higher protein levels match larger or more advanced cancers. T…

This study aims to understand why some adults with advanced cancer who are prescribed opioid pain medication still experience pain and may be hesitant to take their medication. Researchers are exploring fears about opioids and how these fears relate to anxiety, depression, and pa…

This study aims to create and test a new questionnaire to help adult survivors of childhood cancer report their long-term symptoms and health problems. Researchers are working with over 800 survivors to identify which symptoms matter most and to make sure the questionnaire is acc…