CANCER

This study tests a custom-made vaccine designed to train the immune system to attack a person's specific cancer. It is for 136 adults with solid tumors that have not spread or have spread to other parts of the body. The vaccine is made from unique markers on each patient's tumor,…

This study gives venetoclax to people with certain blood cancers who already benefited from it in earlier studies. The goal is to track long-term safety and side effects. About 165 adults are taking part, and they must continue to tolerate the drug well.

This study offers continued treatment with durvalumab to cancer patients who have already completed a previous study and are still benefiting from the drug, as judged by their doctor. About 214 participants will be enrolled to monitor safety and side effects over time. The goal i…

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before starting treatments like chemotherapy or radiation that could harm their fertility. The goal is to later transplant the tissue back to help them become pregnant and have a baby. It is an…

This study tests a web-based program that teaches parents skills to help their children—who are survivors of childhood cancer and have overweight or obesity—eat healthier and be more active. The goal is to prevent long-term health problems like heart disease. About 520 families w…

This study tests a new way to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one heart-related condition will be enrolled. Their primary care doctors will work more cl…

This early-phase study tests a new drug called IMA401 in about 95 adults with advanced solid tumors (like lung or head/neck cancer) that came back or didn't respond to prior treatments. IMA401 is a special immune molecule that helps the body's T cells attack cancer cells. The stu…

This study offers ongoing access to the cancer drug atezolizumab for patients who were already benefiting from it in earlier Roche-sponsored trials. It includes up to 1,000 participants and focuses on safety and continued treatment. The goal is to provide uninterrupted therapy fo…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This early-phase study tests a new treatment called ACIT-1, which uses immune cells from a healthy donor to help fight cancer. The main goal is to find the safest dose and see if it can boost the body's immune response against tumors. The trial includes 34 adults with pancreatic …

This study offers continued treatment with atezolizumab (a cancer immunotherapy) to patients who were already receiving it in a previous Roche-sponsored trial. It includes about 382 adults with various cancers. The goal is to keep providing the drug and monitor long-term safety a…

This early-stage study tests a new drug, RP2, in 36 adults with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest dose and see if RP2 works better when combined with another immunotherapy. The study focuses on safety and tumor re…

This study tests a clinic-based program called ActivityChoice that helps cancer survivors become more physically active to lower their risk of heart disease. About 114 adult cancer survivors will be offered a choice of group in-person, group virtual, or self-monitored digital exe…

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than standard chemotherapy (cisplatin) plus radiation for people with advanced head and neck cancer. About 126 participants with p16-positive cancer will be randomly assi…

This study tests a drug called RP1, which is injected directly into skin tumors, for people who have had an organ or stem cell transplant and now have advanced skin cancer. The goal is to see if RP1 can shrink tumors safely without harming the transplanted organ. About 69 partici…

This study offers continued treatment with the drug osimertinib to cancer patients who were already benefiting from it in a previous clinical trial. The goal is to keep providing the drug while monitoring for serious side effects. About 37 participants are enrolled, and the study…

This study tests a daily combination of sirolimus, celecoxib, and low-dose chemotherapy in 46 children whose solid or brain tumors have returned or not responded to standard treatment. The goal is to see if this approach can shrink or stabilize the tumors. Researchers also track …

This study tests a personalized care plan for older adults (65+) starting chemotherapy. The plan uses a questionnaire to identify risks like frailty or other health issues, then guides doctors to adjust care. The goal is to see if this approach can lower severe side effects and h…

This study looks at a new way of giving standard chemotherapy (R-CHOP) to older adults aged 75 and up with diffuse large B-cell lymphoma. The goal is to see if splitting the doses makes treatment easier to tolerate while still being effective. About 27 participants will receive t…

This study tests a targeted radiation therapy (177Lu-PSMA) in 83 people with advanced or metastatic cancers that have a specific marker (PSMA) on PET scans. The treatment aims to control the disease and monitor side effects. Participants receive up to 4 cycles of the therapy, wit…

This study offers ongoing darolutamide treatment to cancer patients who previously took part in Bayer-sponsored studies and are still benefiting from the drug. About 402 participants will continue their same dose and attend regular check-ups. The main goal is to monitor any side …

This study tests whether combining two immunotherapy drugs, atezolizumab and tiragolumab, can help control cancers where doctors cannot find the original tumor. About 4 adults whose cancer has not responded to chemotherapy will receive the drugs. Researchers will monitor side eff…

This early-phase study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goal is to find the safest dose and check for side effects. About 44 adults who have tried other tre…

This early-phase study tests an experimental drug called cofetuzumab pelidotin in about 65 adults with a specific type of advanced lung cancer (non-small cell) that has returned after standard treatments. The drug is designed to seek out and attack cancer cells that have a protei…

This early-phase study tested a new oral drug called AZD6244 in 58 adults with advanced solid tumors that had stopped responding to standard therapies. The main goal was to check the drug's safety and how the body processes it. Researchers monitored side effects, vital signs, and…

This early-stage study tests a new drug called TT125-802 in about 50 adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check the drug's safety and find the best dose. Researchers will also watch for signs that the drug sh…

This early-phase study tests an experimental drug called RNDO-564, alone or with pembrolizumab, in adults with advanced solid tumors (like bladder, lung, or breast cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the best dose,…

This study tests the safety of a device called TheraSphere for men with localized prostate cancer. It uses tiny radioactive beads to deliver radiation directly to the tumor. The goal is to find the highest safe dose and see what side effects occur. About 36 men will take part in …

This early-phase study tests an experimental oral drug, HBI-2376, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have specific KRAS or EGFR gene mutations. The main goal is to find the safest dose and check for side effects. About 42 participan…

This study looks at whether a simple, 30-second ECG test using a handheld device can find hidden atrial fibrillation (an irregular heartbeat) in cancer patients aged 65 and older. About 494 participants will be randomly assigned to either get the quick screening or usual care. Th…

This study tests a new radioactive imaging agent called [18F]-C-SNAT4 to see how it spreads in the body and whether it can help detect lung cancer tumors. About 20 healthy volunteers and people with lung cancer will receive the agent and have PET scans. The goal is to understand …

This trial is testing a new blood test, called Galleri, that looks for signs of many different cancers. The goal is to see if adding this test to standard NHS screening can catch cancers at an earlier, more treatable stage. Over 140,000 people aged 50-77 in the UK are taking part…

This study looks at whether personalized mail and a short phone chat can help women who had chest radiation for childhood cancer get mammograms. About 360 women aged 25-49 who haven't had a mammogram in two years will take part. The goal is to catch breast cancer early and improv…

This study tests a family program called Turtle Island Tales that helps American Indian families living in poverty prevent obesity and cancer. About 200 caregivers with children ages 3 to 8 will take part. The program focuses on healthy eating, physical activity, less screen time…

This large study tested whether taking daily vitamin D and omega-3 (fish oil) supplements could lower the risk of developing cancer, heart disease, or stroke in healthy older adults. Over 25,000 men and women aged 50+ took the supplements for about 5 years. The goal was to see if…

This study tests a program that helps advanced cancer patients recover at home after a hospital stay. It uses remote monitoring of symptoms and vital signs, plus home visits when needed. The goal is to see if this approach is practical and improves care for 110 adults with advanc…

This study tests a digital program called EMBody that helps young people aged 16-25 who have finished cancer treatment develop healthier mindsets about their bodies. The goal is to improve their quality of life and overall wellbeing. 105 participants will use the program and repo…

This study tests a new approach to help childhood cancer survivors who struggle with memory, attention, and thinking after their treatment. Participants use a special light device at home while doing brain-training exercises. The goal is to see if this is practical and if it can …

This study looks at whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help reduce pain, nausea, diarrhea, and insomnia in people who have had major cancer surgery. The study will include 20 adults with cancer that has spread to the abdomen. The ma…

This study tests an electronic symptom management system (Nurse AMIE) in 344 people with stage 3 or 4 cancer living in rural areas. The goal is to see if using the system helps them live longer and improves their quality of life. Participants use the system to report symptoms and…

This study looks at whether fasting for 24 hours before and after chemotherapy is safe and acceptable for people with lymphoma. About 40 patients will either fast or receive standard care. Researchers will track side effects, weight changes, and quality of life to see if a larger…

This study tests if a special cooling mat can reduce hot flashes and night sweats in people taking hormone therapy for breast or prostate cancer. About 40 adults will use the mat for 8 weeks and track their symptoms. The goal is to see if this simple, non-drug approach improves c…

This study looks at whether a progressive exercise program can reduce long-term nerve pain in veterans who have had lung cancer. Nine veterans aged 60-80 who finished treatment at least 6 months ago will take part. The goal is to see if exercise can improve pain, fitness, and str…

This study looks at whether adding a palliative care team early—before surgery—helps people with cancer feel better physically and emotionally. About 236 adults having certain abdominal cancer surgeries will either get usual care or usual care plus extra support from a palliative…

This study looks at whether support from community health workers can help African American patients with advanced cancer feel better and have a higher quality of life. About 160 patients will either get standard care or standard care plus extra help from a community health worke…

This study followed 492 adults with cancer who joined a supervised exercise program in community settings. The program included aerobic, strength, and functional training, offered in person or online. Researchers measured how often participants attended sessions, their quality of…

This study is testing a culturally adapted mind-body program (meditation and support) to help Black patients with stage III or IV cancer feel better. Researchers will first talk with patients and caregivers to tailor the program, then test it in a small trial with 170 participant…

This study tests whether a mobile health program can help teens and young adults who finished cancer treatment become more physically active. About 287 survivors in Alberta will either get standard educational materials or a full program including a personalized activity plan, a …

This study looks at whether kava, a plant used for relaxation, can safely reduce anxiety and stress in people who have finished cancer treatment. About 43 survivors of breast, gynecologic, lung, or head/neck cancer will take either kava or a placebo for 14 days, then switch after…

This study looks at whether giving $1,000 each month for a year to people with advanced cancer can ease their money worries and improve their quality of life. About 250 adults with stage 3 or 4 cancer who are on Medicaid in Pennsylvania will take part. They will receive the month…

This study tests whether an 8-week digital health program called COBRA is safe and practical for older adults with cancer. The program focuses on balance and resistance exercises to help maintain strength and mobility. Researchers will track how many participants stick with the p…

This study tests whether electroacupuncture (a type of acupuncture with mild electric current) can reduce common symptoms like memory trouble, fatigue, insomnia, and anxiety in cancer patients and survivors. About 70 participants will receive either real or sham electroacupunctur…

This study tests a group program to help teens and young adults (ages 16 and up) who finished cancer treatment in the last 5 years learn to manage stress. The program, called 3RP-AYA, teaches relaxation and coping skills. The goal is to see if it is practical and helpful for redu…

This study is testing a phone app called OnKO-Tips&Tricks for teens and young adults (ages 15-25) recently diagnosed with cancer. The app helps them track daily symptoms, learn about their condition, and stay in touch with a nurse. The goal is to see if using the app for 6 months…

This study looks at whether helping cancer patients with money and social needs (like food, housing, or transportation) can improve their treatment and well-being. About 91 newly diagnosed cancer patients who report financial hardship will receive either one-on-one financial coun…

This study looks at whether cancer patients who are not expected to be cured benefit from being referred to a palliative care team during an emergency room visit. About 240 adults with advanced cancer will be randomly assigned to either standard care or a systematic referral to p…

This study tests four add-on features (e-coaching, a buddy, general mindfulness, and exercise-specific mindfulness) in a 12-week mobile health program for 304 young adult cancer survivors. The goal is to see which features best increase moderate-to-vigorous physical activity and …

This study looks at two different ways to manage symptoms in cancer patients who are new to palliative care. The goal is to see which approach helps improve quality of life. About 208 adults from Pennsylvania are taking part. Researchers will measure well-being using a simple que…

This study tests whether a drug called psilocybin (found in magic mushrooms) can safely reduce depression in adults who have both cancer and major depressive disorder. About 56 participants will receive up to two doses of psilocybin or a placebo, with therapists present. The goal…

This pilot study explores whether chiropractic care can reduce chronic fatigue in adults who have finished cancer treatment and are now cancer-free. About 40 participants will be randomly assigned to receive chiropractic adjustments or continue usual care. The main goal is to see…

This study tests a 7-week group program led by trained peers (not doctors) to help cancer survivors reduce anxiety and depression after finishing curative treatment. 234 adults in Denmark who completed cancer treatment within the past year and have mild-to-moderate symptoms are t…

This study tests a program to help Hispanic cancer survivors and their caregivers eat healthier and be more active. The goal is to reduce common symptoms like pain, sleep trouble, and anxiety. About 187 survivors and their caregivers will take part in this 25-week program.

This study tests if a therapy called Acceptance and Commitment Therapy (ACT) can help cancer patients handle difficult thoughts and feelings better. About 120 adults with breast, lung, or colorectal cancer will be split into three groups: one gets ACT in person plus an app, one g…

This study looks at whether using a fitness tracker and a phone app can help people with cancer stay active during their treatment. Twenty-five participants will wear the tracker and use the app for three months to monitor their steps, exercise minutes, and strength training. The…

This study looks at whether a support program can help small rural hospitals meet national cancer care quality standards. Researchers will work with hospital staff to provide training and resources, then check if cancer patients get better treatment. The goal is to improve care f…

This study looks at whether a special checklist can help Chinese adults in Chicago get recommended cancer screenings and address social needs like housing or food. About 600 people from Chinatown are taking part. The goal is to see if this simple tool makes it easier for patients…

This study looks at whether it is possible to track memory and concentration changes in adults aged 65 and older who are starting a type of cancer treatment called immune checkpoint inhibitors. Over six months, 30 participants will take simple memory and thinking tests every six …

This study tests whether a wearable skin sensor can tell how much pain a person is feeling. Thirty-seven adults with cancer or COPD will wear the device for up to a week and rate their pain. The goal is to create an algorithm that automatically detects rising pain levels and aler…

This study was designed to track how the immune system recovers after CAR-T cell therapy and whether a pneumonia vaccine (PCV-21) given six months later can work. It planned to enroll 50 adults with blood cancers or solid tumors. However, the study was withdrawn before any partic…

This study looks at whether people over 65 with cancer can use an online system to regularly report their symptoms and quality of life during treatment. The goal is to see if this kind of remote monitoring is practical and helpful for managing care at home. About 33 participants …

This early-phase trial is testing whether the cholesterol drug atorvastatin can lower levels of a faulty protein (mutant p53) in people with solid tumors or relapsed acute myeloid leukemia. About 50 participants will take atorvastatin for 1 to 4 weeks before their planned surgery…

This study tests a new total body PET scanner that may allow lower radiation doses and faster scans without losing image quality. Twenty-five adults with cancer will get both a standard PET scan and a scan on the new machine, using the same radioactive tracer. The goal is to see …

This study tests a training program called CASCADE for family caregivers of people with advanced cancer. The goal is to see which parts of the training best help caregivers support their loved one in making medical decisions. 256 caregivers will receive different combinations of …

This study tests whether a group education program can help medically underserved women and racial/ethnic minorities with BRCA 1 or 2 mutations better follow recommended cancer screenings and risk-reducing procedures. About 30 participants will take part to see if the approach is…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill in the Gulf of Mexico. Researchers want to see if exposure to oil and chemicals during cleanup leads to long-term health problems like heart disease, cancer, or lung issues. Participant…

This study is trying to find blood markers that could warn doctors ahead of time if a cancer patient will have serious side effects from immunotherapy drugs. About 69 adults with advanced solid tumors are being followed to see if certain inflammatory or autoimmune markers in thei…

This study was designed to look back at medical records to see how often people diagnosed with lymphoma also had another cancer within six months. Researchers planned to describe patient characteristics and explore possible causes. However, the study was withdrawn before any part…

This study is testing whether a nutrition program called BfedBwell can work for cancer survivors who are overweight or have obesity. The program includes one-on-one counseling with a dietitian, learning new skills, and group support. The main goal is to see if people will join an…

This study looks at the link between eating nuts and the risk of developing serious diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine data from over 1 million adults worldwide to get clearer answers. The goal is to understand if nuts can help p…

This study looks at how the COVID-19 pandemic affected the number of new cancer cases found in Bavaria, Germany. Researchers analyzed over 438,000 cancer diagnoses from 2018 to 2023 to see if certain regions, age groups, or cancer types were more impacted. The goal is to understa…

This study collects tumor tissue from about 416 people with various advanced cancers to develop and train a new diagnostic platform called Elephas. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy, compared to standard met…

This study looks at the experiences of cancer patients who receive care at home through MD Anderson's Care and Monitoring at Home program. Researchers will use surveys to understand how patients feel about this type of care. The goal is to learn how to improve the program for fut…

This study tests an online questionnaire called CHAMP that older adults with cancer can fill out before their doctor visit. The tool helps doctors understand each patient's overall health to choose the best treatment and support. About 180 people aged 65 and older from four hospi…

This study compares different outreach strategies to see which works best for enrolling African American patients into early-phase cancer treatment trials. About 134 patients and their doctors will take part, with some receiving special outreach and others standard care. The goal…

This study looks at whether the standard blood test given to pregnant women to check for fetal genetic conditions can also reveal signs of cancer in the mother. Researchers will analyze DNA from 300 pregnant women who have or develop cancer during pregnancy. The goal is to identi…

This study looks at how diet, lifestyle, and genetics influence the risk of getting endometrial cancer. Researchers will compare women who have or had the cancer with those who do not. The goal is to identify factors that may lead to the disease. About 1,315 women from New Jersey…

This study was designed to test a new imaging agent called 68Ga-FAPI-46 in people with solid tumors. The goal was to see if a PET/CT scan using this agent could predict how well a patient's tumor would respond to antibody-based therapy. The study was withdrawn before enrolling an…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring for long-term effects, especially on cancer, dementia, and disability. No new treatment is given—participants just continue regular check-ups and phone calls to…

This study aims to find the best settings for MRI scans used during radiation therapy for cancer. Researchers will test different scan parameters on both cancer patients and healthy volunteers to get clearer, more accurate images. The goal is to improve how doctors see tumors and…

This study aimed to see if adding simple visual summaries to consent forms helps cancer patients better understand and feel less anxious about joining clinical trials. It was designed for adults with cancer who were already considering a trial. However, the study was withdrawn be…

This study tests a digital self-management and peer mentoring program for young adults (ages 18-25) who survived childhood cancer. The goal is to help them stay engaged in follow-up care as they move from pediatric to adult healthcare. Participants will use an online tool and get…

This study collects health information from one million people across Africa to better understand noncommunicable diseases like heart disease, cancer, and diabetes. Researchers will track who gets these diseases and why, focusing on risk factors like weight, blood pressure, and s…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study is watching how a blood test called Galleri performs when used in everyday clinics to find cancer early. About 14,000 adults who chose to take the test are taking part. The goal is to see how well the test detects cancer signals and how patients feel about it.

This study tests a new MRI guidance software called Philips Interventional iSuite to see if it helps doctors place needles more quickly and accurately during biopsies and tumor ablations. About 12 people already scheduled for an MRI-guided procedure will take part. The goal is to…

This study collects blood samples from people who have unexpected or severe side effects from drugs they are taking for cancer. The goal is to measure drug levels in the blood to understand why side effects happen in some people but not others. Participants must be at least 2 yea…

This study surveys 100 cancer patients at a pain clinic to learn how they use cannabis and CBD, including how often and why. The goal is to understand where patients get their information and how interested they are in using these products for symptom relief. No treatment is give…

This study aims to find better ways for doctors and patients to talk about what matters most when facing a serious illness like cancer, heart failure, COPD, or dementia. Researchers will track how often and how early these conversations happen in the last six months of life. The …

This study looks at whether two substances in the blood, called IGF-1 and IGF-1Ec, are linked to how much cancer is in the body. Researchers will measure these levels in 100 adults with solid tumors and compare them to tumor size, stage, and spread. The goal is to see if these ma…

This study surveys radiation oncology doctors and staff at Duke Cancer Center to understand their experience using telehealth instead of in-person visits during the COVID-19 outbreak. Researchers will track how many virtual visits were missed and whether patients ended up in the …

This study tests a new way to deliver radiation therapy for cancer using an MRI machine built into the radiation device. The goal is to see if this approach can more precisely target tumors while reducing side effects. About 377 adult cancer patients will receive this treatment a…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with social services like housing assistance, food support, and financial aid. About 400 adults receiving cancer treatment or in survivorship at Minnesota clinics will use the pla…

This study looks at over 5,000 people and their families who have a high risk of cancer. Researchers want to find out which genes and environmental factors increase cancer risk. Participants provide medical history, answer questionnaires, and donate samples. No treatment is given…

This study looks at better ways to detect heart damage in adult cancer survivors who received certain chemotherapy drugs. Researchers are testing if an AI-powered ECG and a simple blood test can find early signs of heart trouble. The goal is to gather information needed to create…

This early study tests whether frozen testicular tissue can be grafted back into men to produce sperm. It involves 5 men aged 40 or older who are having routine groin surgery. The goal is to see if this approach could one day help boys and men who lose fertility due to cancer tre…

This study collects and analyzes medical information from up to 75,000 cancer patients who received proton therapy or standard X-ray radiation at Loma Linda University Medical Center. By following participants for many years, researchers aim to learn which radiation approaches wo…

This study follows 180 cancer patients whose cancer has spread to the thigh bone, putting them at high risk of a fracture. Researchers compare outcomes between those who have surgery (with or without radiation) and those who receive radiation alone. The goal is to see which appro…

This study looks at whether a blood test (liquid biopsy) can find cancer mutations as well as the standard tissue biopsy in 1,500 advanced cancer patients. The goal is to see if the blood test helps doctors choose better treatments and saves healthcare money. Participants either …

This study tests whether an educational video can help adults with serious cancer understand and use palliative care, which focuses on relieving symptoms and improving quality of life. About 172 participants will be split into two groups: one gets standard care plus brochures, th…

This study explores whether adding a wearable device (like a smartwatch) to a home symptom monitoring program helps cancer survivors better track their health. Researchers will check how many patients agree to use the wearable and how well they stick with it. The goal is to find …

This study looks at how community cancer clinics ask patients about social needs like housing, food, or transportation. Researchers will work with 144 clinic staff to find what helps or hinders these screenings. The goal is to create custom plans so clinics can better connect pat…

This study provides standard cancer care to patients at the National Cancer Institute while collecting their medical information for research. It is open to adults and children aged 2 and older who need cancer treatment or consultation. No experimental therapies are offered; the …

This study gathers information from the medical records of 10,000 people with cancer. Researchers will analyze this data to better understand patient characteristics, treatment patterns, and outcomes. The goal is to help design better clinical trials, support drug approvals, and …

This study aims to make genetic testing easier for parents of children who have a cancer-related gene mutation. Researchers will use online tools and telemedicine to offer genetic counseling and testing. The goal is to see if this approach helps more family members learn about th…

This study looked at whether regular screening for prostate, lung, colorectal, and ovarian cancers can reduce deaths from these diseases. About 155,000 men and women aged 55-74 were randomly assigned to either get screened or receive usual care. Researchers tracked cancer cases a…

This study looks at how certain cancers (head and neck, esophagus, and anal) change at the genetic and immune level when treated with chemotherapy or immunotherapy. About 39 adults with advanced cancer will provide blood and tumor samples before and during treatment. The goal is …

This study looks at whether a special health check for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with doctors about age-related concerns during cancer treatment. About 479 patients, caregivers, and clinic staff are takin…

This study was designed for adults with certain types of soft tissue sarcoma that have specific immune cell clusters (TLS). Participants would have received either pembrolizumab alone or combined with olaparib before surgery, followed by more pembrolizumab after. The goal was to …

This study tests whether using a visual consent form with pictures and simple language helps patients better understand research studies for cancer and Alzheimer's disease. Researchers will compare the standard consent process to the new visual approach with 266 patients and rese…

This study tests whether a computer character that talks and gestures can help cancer patients fill out symptom surveys more completely. About 100 adults with gastrointestinal or head and neck cancer will use the system during treatment. The goal is to see if this approach reduce…

This study looks at the cells and non-cellular material (stroma) inside benign and malignant tumors. Researchers will analyze samples from 7,000 patients collected since 2000 at Brest University Hospital. The goal is to describe what makes up the tumor environment, not to test a …

This study was designed to learn how well the healthcare system supports adolescents and young adults (ages 12-39) living with advanced or recurrent cancer. Researchers planned to survey patients, caregivers, and clinicians about emotional, spiritual, and communication needs, and…

This study tests whether artificial intelligence (AI) can accurately summarize conversations between doctors and patients with advanced cancer about their care goals. About 60 patients from Dana-Farber Cancer Institute will have their serious illness talks summarized by an AI pro…

This study is creating and testing a new questionnaire for adult survivors of childhood cancer to report their symptoms. The goal is to better understand and manage long-term side effects from past cancer treatments. About 837 survivors will help validate this tool, which could i…

This study looks at different ways to share genetic research results with people who joined a biobank. Researchers want to see if using a website or chatbot is as good as talking to a genetic counselor by phone or video. About 2,500 adults with certain genetic changes will take p…

This study follows about 60 adults who have already received SynKIR CAR T cells for cancer. The main goal is to watch for any delayed side effects and to see how long the treatment's effects last. Participants do not receive any new treatment in this study.

This study is testing a blood test that looks for signs of many different cancers at once, before symptoms appear. About 35,000 people aged 50 and older will take the test and be followed for three years. The goal is to see how well the test works and whether it leads to unnecess…

This study looks at why some African American women don't exercise often and tests whether teaching them to support a partner's exercise habits can help them become more active. About 80 sedentary women aged 18-65 will take part. The goal is to see if this buddy approach increase…

This study looks at how cancer affects the identity, friendships, and family relationships of teens and young adults who have survived the disease. Researchers will interview and survey 300 survivors aged 15 to 25 who finished treatment at least 6 months ago. The goal is to learn…

This study looks at how mind-body therapies—like mindfulness, laughter yoga, and art therapy—affect the quality of life and emotional distress of 150 cancer patients. Participants will fill out questionnaires before and after an 8-week program. The goal is to see if these therapi…

This study looks at how the immune system in the gut changes when people with cancer receive immunotherapy. Researchers will take small tissue samples from the gut and blood samples before and during treatment. The goal is to learn more about the body's response, not to test a ne…

This study follows 150 adults aged 65 and older who are receiving radiation therapy for cancer. Researchers will track how well patients complete treatment and how their daily function and side effects change over time using surveys and physical tests. The goal is to help doctors…

This study looks at whether older adults with cancer can use computer surveys to share their health information. Researchers will test two different computer methods to see which is easier and more reliable. The goal is to make it simpler for doctors to understand and help their …

This study brings together 265 experts to create clear, consistent definitions for key time-to-event endpoints in cancer clinical trials, such as progression-free survival. By standardizing these definitions across different cancer types, researchers hope to make trial results ea…

This study takes a small piece of a patient's cancer and grows it in lab mice. Doctors then test different drugs on the mouse tumors to see which ones work best. The results are shared with the patient's oncologist, who decides on treatment. The goal is to see if this approach he…

This study looks at why some adults with advanced cancer are afraid to take opioid pain medicine, even when prescribed. Researchers will survey 50 patients to understand how fear, anxiety, and depression affect pain relief and medication use. The goal is to learn what barriers ex…

This study collects blood and urine samples from 1,000 adults who are receiving radiation therapy for cancer. Researchers want to learn how radiation affects genes in white blood cells, damages red blood cells, and changes hormone levels. Samples are taken before, during, and aft…

This study takes blood samples from 25 cancer patients before and during radiotherapy to measure gene activity changes caused by radiation. The goal is to find a set of genes that can show how each person's body responds to treatment. This is an observational study that does not …

This study aimed to see if a cancer patient's mindset—their beliefs about their illness and their body—could affect their quality of life and treatment outcomes. Researchers planned to follow newly diagnosed patients through treatment and test a brief program to encourage helpful…

This study looks at whether using a Fitbit and a continuous glucose monitor (CGM) is a practical way to track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people are w…