New online program aims to ease pain for cancer survivors

NCT ID NCT04462302

Symptom relief Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study tests whether an internet-based pain coping skills program can help cancer survivors manage ongoing pain. About 456 adults who have completed cancer treatment or are on maintenance therapy will take part. Participants will either get the online program plus enhanced usual care, or enhanced usual care alone, and researchers will measure changes in pain severity and how much pain interferes with daily life.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 456 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2021

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Must have a documented diagnosis of invasive cancer that has been treated with either single modality therapy or any combination of surgery, radiation, and chemotherapy/drug therapy (e.g. cytotoxic therapy, targeted therapy, immunotherapy, hormonal therapy, etc.). Patients with a cancer history of only superficial skin cancers or in situ malignancy are not eligible. * May be either off all treatment OR actively receiving anticancer therapy in an adjuvant setting, maintenance setting, or for active cancer. * Patients who currently undergoing anticancer therapy should not have any plans to change or adjust their treatment during the intervention period. This includes changing to another therapy or ending therapy entirely. * Patients who are currently receiving anticancer therapy at the screening process must have been on current therapy for at least four weeks. Alternatively, if they are planning to discontinue therapy before enrolling, they must have been off therapy for four weeks prior to enrollment. * A minimum of four weeks must have elapsed since the most recent MAJOR surgical intervention. * A minimum of two weeks must have elapsed since the most recent MINOR surgical procedure (e.g., port placement). * In addition, eligible patients must not have a planned surgical procedure or course of radiation therapy during the 3-month study intervention period (i.e., the three months leading up to primary outcome evaluation-timepoint. * Patients who are no longer receiving anticancer therapy must be less than/equal to 5 years since the completion of their anticancer therapy (e.g., time since the last day of chemotherapy administration, time since last day of radiotherapy, etc.). * Must have pain indicated by a score of ≥ 4 on PROMIS Pain Intensity (1a) scale, using the Pain Eligibility Interview. * Must have a score of "Most Days" or higher on the Graded Chronic Pain Scale Revised (Abbreviated) using the Pain Eligibility Interview. * Patients do not have to be on analgesic medications of any kind in order to participate. If they are taking analgesics, they must be on a stable analgesic regimen (i.e., no changes to the prescribed analgesic regimen) over a period of at least 14 days prior to enrollment. Eligible patients should not have planned upward dose titration of their analgesics during the 3-month study intervention period (i.e., the three months leading up to primary outcome evaluation timepoint. Patients may elect to decrease their analgesic use during the study as per discussions with their provider. Unexpected dose adjustments including dose escalations as a result of unforeseen clinical need is allowed in all patients at all times during the study. Cannabis prescribed for medicinal purposes would qualify as an analgesic in this context. * Must have pain of new onset or significantly exacerbated since the time of cancer diagnosis or initiation of cancer treatment * Must be expected to be able to complete all study activities including the 22- and 34-week follow-up assessments according to the treating/referring clinician (e.g., treating clinician feels the patient is unlikely to develop progressive disease requiring additional active cancer therapy through the 6-month follow-up period). * ECOG performance status of 0, 1, or 2. * Age ≥18 years at the time of study entry * Must be able to speak, read and understand English. Exclusion Criteria: * Has a disability that precludes completion of study activities (e.g., severe vision or hearing impairment, diagnosis of dementia or clinical evidence of severe cognitive impairment, diagnosis or clinical evidence of severe psychiatric disorder, or diagnosed drug or alcohol abuse disorder), as per patient report or documented in the medical record. * Reports only preexisting pain conditions unrelated to cancer or cancer treatment (e.g., migraine or tension headache, arthritis, back disorders, bursitis/tendonitis, injuries, fibromyalgia). * Has a known or suspected diagnosable substance use disorder or opioid overuse disorder (according to DSM-5 criteria), or is actively receiving treatment for a substance use disorder, as per patient report or documented in the medical record. * Currently being prescribed buprenorphine or suboxone. * Patients enrolled on hospice care or end-of-life palliative care are not eligible for enrollment. Patients whose local care network provides an opportunity for palliative (symptom management) or supportive care concurrent with active treatment following diagnosis (i.e. not solely as a palliative or end-of-life measure) are considered eligible for this study. * Does not have reliable access to Internet or sufficient personal data plan, and is not willing to participate in the Tablet Lending Program provided for this study. * Does not have a working email address.

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Conditions

The condition(s) this trial relates to.

cancer Cancer Pain neoplasm Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Broadlawns Medical Center

Des Moines, Iowa, 50314, United States
CHRISTUS Highland Medical Center

Shreveport, Louisiana, 71105, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Carle BroMenn Medical Center

Normal, Illinois, 61761, United States
Carle BroMenn Outpatient Center

Bloomington, Illinois, 61704, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Cancer Institute Normal

Normal, Illinois, 61761, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Carle on Vermilion

Danville, Illinois, 61832, United States
CentraState Medical Center

Freehold, New Jersey, 07728, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Chilton Medical Center

Pompton, New Jersey, 07444, United States
Community Medical Center

Scranton, Pennsylvania, 18510, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
FHP Health Center-Guam

Tamuning, GU, 96913, Guam
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Flaget Memorial Hospital

Bardstown, Kentucky, 40004, United States
Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, 48503, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Hackettstown Medical Center

Hackettstown, New Jersey, 07840, United States
Hawaii Cancer Care - Savio

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Illinois CancerCare - Washington

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
John B. Amos Cancer Center

Columbus, Georgia, 31904, United States
Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States
Kaiser Permanente Dublin

Dublin, California, 94568, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center-Vacaville

Vacaville, California, 95688, United States
Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente- Marshall Medical Offices

Redwood City, California, 94063, United States
Kaiser Permanente-Deer Valley Medical Center

Antioch, California, 94531, United States
Kaiser Permanente-Franklin

Denver, Colorado, 80205, United States
Kaiser Permanente-Fremont

Fremont, California, 94538, United States
Kaiser Permanente-Fresno

Fresno, California, 93720, United States
Kaiser Permanente-Lone Tree

Lone Tree, Colorado, 80124, United States
Kaiser Permanente-Modesto

Modesto, California, 95356, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Richmond

Richmond, California, 94801, United States
Kaiser Permanente-Rock Creek

Lafayette, Colorado, 80026, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South Sacramento

Sacramento, California, 95823, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Stockton

Stockton, California, 95210, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser San Rafael-Gallinas

San Rafael, California, 94903, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Knox Community Hospital

Mount Vernon, Ohio, 43050, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
MaineHealth Cancer Care Center of York County

Sanford, Maine, 04073, United States
Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin, 54494, United States
Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin, 54729, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Ladysmith

Ladysmith, Wisconsin, 54848, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Neillsville

Neillsville, Wisconsin, 54456, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center Dickinson

Iron Mountain, Michigan, 49801, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Medical Oncology and Hematology Associates-Des Moines

Des Moines, Iowa, 50309, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Memorial Hospital

Marysville, Ohio, 43040, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Newton Medical Center

Newton, New Jersey, 07860, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Baptist Medical Center

New Orleans, Louisiana, 70115, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Overlook Medical Center

Summit, New Jersey, 07901, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Peninsula Cancer Institute - Cancer Specialists of Tidewater

Virginia Beach, Virginia, 23235, United States
Peninsula Cancer Institute - Gloucester

Gloucester, Virginia, 23061, United States
Peninsula Cancer Institute - Newport News

Newport News, Virginia, 23601, United States
Peninsula Cancer Institute - Williamsburg

Williamsburg, Virginia, 23185, United States
Physicians' Clinic of Iowa PC

Cedar Rapids, Iowa, 52402, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital East

Lexington, Kentucky, 40509, United States
Saint Joseph London

London, Kentucky, 40741, United States
Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504, United States
Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910, United States
Saint Peter's University Hospital

New Brunswick, New Jersey, 08901, United States
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
South Carolina Cancer Specialists PC

Hilton Head Island, South Carolina, 29926, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States
Tidelands Georgetown Memorial Hospital

Georgetown, South Carolina, 29440, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48118, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
Tripler Army Medical Center

Honolulu, Hawaii, 96859, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
VCU Community Memorial Health Center

South Hill, Virginia, 23970, United States
VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235, United States
Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Wake Forest University at Clemmons

Clemmons, North Carolina, 27012, United States
Wake Forest University at Lexington

Lexington, North Carolina, 27292, United States

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