Can freezing ovarian tissue help girls have babies later?

NCT ID NCT02646384

Ongoing Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments that could harm their fertility, such as chemotherapy or radiation. The tissue is removed surgically and stored. Later, if they want to have children, the tissue can be transplanted back. The study is tracking how many pregnancies and live births result from this approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ovarian tissue cryopreservation (freezing and storage of ovarian tissue)
What this could lead to: If successful, this could help girls who need cancer treatment or other therapies to have a chance at biological children later in life.
What could go wrong: This is an early-stage experimental procedure, and it is not yet proven how often it leads to pregnancy. The tissue may not survive transplantation, and risks from surgery exist.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer germ cell tumor lupus nephritis neoplasm ovarian neoplasm Turner syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

More trials for these conditions

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