Personalized vaccine aims to train immune system against cancer

NCT ID NCT05741242

ENROLLING_BY_INVITATION ⭐️ VACCINE ⭐️ Sponsor: Jaime Leandro Foundation for Therapeutic Cancer Vaccines Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial is testing a personalized vaccine made from unique proteins (neoantigens) found in a person's tumor. The goal is to see if the vaccine is safe and can help slow or stop cancer growth in people with solid tumors, including pancreatic cancer. About 136 participants with local or metastatic solid tumors will receive the vaccine. The study is currently enrolling by invitation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Personalized synthetic long peptide vaccine
What this could lead to: If successful, this could lead to a new personalized vaccine that helps the immune system fight solid tumors, potentially slowing or stopping cancer growth.
What could go wrong: This is an early-phase trial (phase 1b/2) with only 136 participants, so results may not apply to all patients. The vaccine is personalized, making it complex and costly, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer glioblastoma neoplasm pancreatic adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER SOLID TUMOR

Contacts and locations

Locations

Anna Gattani MD PC

New York, New York, 10028, United States
Mount Sinai Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
Precision NextGen Oncology & Research Center

Beverly Hills, California, 90212, United States
Quest Clinical Research

San Francisco, California, 94115, United States
St. Louis Cancer Care

Bridgeton, Missouri, 63044, United States

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