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Massive study tests if daily pills can ward off cancer and heart attacks

NCT ID NCT01169259

Ongoing Prevention Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to see if these common supplements can prevent serious illnesses in people without a prior history.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
vitamin D3 (cholecalciferol) and omega-3 fatty acids (fish oil)
What this could lead to
If it works, this could show that simple daily supplements help prevent cancer and heart disease in healthy older adults.
What could go wrong
This is a large, completed phase 3 trial, but results may show no benefit or only modest effects. Supplements are not a substitute for other healthy habits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm cancer prevention target cardiovascular disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CARDIOVASCULAR DISEASE

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

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