New drug HBI-2376 targets Hard-to-Treat cancers in early trial
NCT ID NCT05163028
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tests a new oral drug called HBI-2376 in about 42 adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have KRAS or EGFR mutations and have stopped responding to standard treatments. The main goals are to find a safe dose and understand how the drug moves through the body. It is not yet known if the drug will shrink tumors or improve survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HBI-2376 (a SHP2 inhibitor drug)
- What this could lead to
- If successful, this could lead to a new treatment option for people with advanced cancers that have KRAS or EGFR mutations and have not responded to standard therapies.
- What could go wrong
- This is a very early (Phase 1) trial with only 42 participants, focused on safety and dosing, not on proving the drug works. Many drugs fail at this stage, and side effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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BRCR Medical Center
Plantation, Florida, 33322, United States
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California Cancer Associates for Research and Excellence, Inc. (cCare)
Encinitas, California, 92024, United States
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California Cancer Associates for Research and Excellence, Inc. (cCare)
San Marcos, California, 92069, United States
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City of Hope
Duarte, California, 91010, United States
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Orlando Health, Inc.
Orlando, Florida, 32806, United States
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Pan American Center for Oncology Trials (PanOncology Trials)
Rio Piedras, Puerto Rico, 00935, Puerto Rico
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Providence Medical Foundation
Fullerton, California, 92835, United States
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Sarcoma Oncology
Santa Monica, California, 90403, United States
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Texas Oncology - Tyler
Tyler, Texas, 75702, United States
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UCLA Hematology/Oncology
Santa Monica, California, 90404, United States
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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