Deeper DNA analysis may unlock better cancer care

NCT ID NCT04614480

Recruiting now Knowledge-focused Sponsor: Centre Georges Francois Leclerc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether a more detailed genetic analysis of tumors (called 'complex' exome analysis) helps doctors choose better treatments for people with advanced solid tumors compared to a standard genetic analysis. About 8,000 participants will have their tumor and normal DNA analyzed. The goal is to see if the complex analysis leads to treatments that would not have been possible with the simpler test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Exome analysis (genetic testing of tumor and normal DNA)
What this could lead to: If successful, this could show that a more detailed genetic analysis helps doctors select better, more personalized cancer treatments from the start.
What could go wrong: This is a Phase 2 study, so it is still early. The extra genetic information may not actually improve treatment decisions or patient outcomes. The results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER

Contacts and locations

Locations

CGFL
RECRUITING

Dijon, 21079, France
CHRU Jean Minjoz
RECRUITING

Besançon, France
CHU Amiens Picardie
NOT_YET_RECRUITING

Amiens, France
CHU François Mitterrand
RECRUITING

Dijon, France
CHU Nantes
TERMINATED

Nantes, France
Centre Eugène Marquis
RECRUITING

Rennes, France
Centre Henri Baclesse
RECRUITING

Caen, France
Centre Oscar Lambret
RECRUITING

Lille, France
Chu Poitiers
TERMINATED

Poitiers, France
Institut Bergonie
TERMINATED

Bordeaux, France
Institut Hospitalier Franco-Britannique
TERMINATED

Levallois-Perret, France
Institut JeanGodinot
RECRUITING

Reims, France

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