Frozen testicle tissue may help men become dads after childhood cancer

NCT ID NCT05414045

Recruiting now Disease control Sponsor: Universitair Ziekenhuis Brussel Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men to restore sperm production. Five men who had fertility-threatening treatments as children will receive their own preserved tissue. The goal is to see if sperm can be found in the graft one year later, potentially enabling fatherhood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: autologous testicular tissue transplantation
What this could lead to: If it works, this could offer a way for men who lost fertility due to childhood cancer treatment to have biological children.
What could go wrong: This is a very early trial with only 5 participants, so success is far from guaranteed. The procedure is experimental and may not produce usable sperm, and there are surgical risks.

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Conditions

The condition(s) this trial relates to.

cancer hematologic disorder neoplasm sickle cell-beta plus-thalassemia sickle cell-beta-thalassemia disease syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER HEMATOLOGIC DISEASES SICKLE CELL THALASSEMIA

Contacts and locations

Locations

UZ Brussel Centre for Reproductive Medicine
RECRUITING

Brussels, 1090, Belgium

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