Universitair Ziekenhuis Brussel

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men to restore sperm production. Five men who had fertility-threatening treatments as children will receive their own preserved tissue. The goal is to see if sperm can be found in…

This study is testing whether giving one dose of the immunotherapy drug pembrolizumab six weeks before surgery can help the immune system fight high-risk melanoma more effectively. About 49 adults with melanoma that hasn't spread on scans will receive the drug, then have their ly…

This study tests whether a minimally invasive procedure called Superior Rectal Artery Embolization (SRAE) works as well as rubber band ligation for controlling bleeding from hemorrhoids. SRAE blocks blood flow to the hemorrhoids using tiny particles, and is done under local anest…

This phase II trial is testing a new radioactive imaging agent called 68GaNOTA-Anti-MMR VHH2. It is designed to attach to certain immune cells (macrophages) in non-small cell lung cancer tumors and make them visible on a PET scan. The study will involve 20 patients who are alread…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

This study tests a new CT scan that works without an ECG to quickly check for heart disease in people with chest pain and high troponin levels. About 230 adults will get this scan plus the standard invasive test to see if the new method is accurate. If successful, it could reduce…

This study is testing whether giving healthy newborns a probiotic supplement (L. reuteri) can prevent colic and excessive crying. About 768 babies will receive either the probiotic or a placebo daily for the first 3 months. Researchers will track crying, fussiness, and stool patt…

This pilot study tests whether a video-based prehabilitation program—including education, stress management, and physical activity coaching—can help people prepare for total knee replacement surgery. Forty adults scheduled for knee replacement will either receive this program or …

This study looks at whether adding a nerve block to a standard steroid injection helps people with frozen shoulder feel less pain and move better. About 110 adults with frozen shoulder will get either the combo treatment or a steroid injection alone. The goal is to see if the ner…

This study tests whether a home-based program combining computer brain games with physical exercises can improve thinking and walking in people with multiple sclerosis (MS). Ninety adults with MS will be randomly assigned to different training groups. The goal is to see if the co…

This study looks at whether regular cardiovascular exercise (like walking, jogging, or cycling) can reduce the severity of irritable bowel syndrome (IBS) symptoms in adults who currently have a sedentary lifestyle. Researchers will enroll 30 participants aged 18-60 with moderate-…

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This phase 3 trial tests whether a low FODMAP diet can improve symptoms and quality of life in people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Sixty participants will follow the diet with guidance from a dietitian. The goal is …

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study is looking for new blood markers that could show how much scarring (fibrosis) is in the liver of people with chronic liver disease. Researchers will compare these markers to current tests like FibroScan and liver biopsy. The goal is to find a more accurate and less inv…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study looks at how well patients who have recently left the ICU absorb nutrients from tube feeding. By measuring the energy in patients' stool and their resting metabolism, researchers hope to understand if current feeding practices meet patients' needs. The goal is to impro…

This study involves 200 adults having non-heart surgery under general anesthesia. Researchers will collect data from a standard muscle monitor to build a computer model that predicts when muscles fully recover from paralysis drugs. The goal is to improve safety and reduce complic…

This study looks at how the body's cells use oxygen in people with long COVID compared to those fully recovered. Researchers will measure oxygen use in blood cells, skin, and muscle to see if there are differences. The goal is to better understand long COVID and test if these mea…

This study looks at whether babies born with certain self-reactive antibodies are more likely to develop eczema. Researchers will test umbilical cord blood from 500 newborns—some with a family history of allergies or eczema, some without—and follow them for two years. The goal is…

This study compares an AI algorithm (iDAScore) to human embryologists in ranking embryos for IVF. About 1,325 patients will have their embryos ranked either by the AI or by a specialist, then transferred one by one until a pregnancy is achieved. The goal is to see if the AI can m…

This study is testing a new online food questionnaire to see if it can accurately measure what people eat, including FODMAPs (certain carbs that can cause digestive issues). Researchers will compare the questionnaire to a standard 4-day food diary in 400 adults, both with and wit…

This study looks at whether a simple breath test can tell if people with moderate to severe irritable bowel syndrome (IBS) will feel better on a lactose-free diet. About 90 adults with IBS will take the breath test and then follow a lactose-free diet for 4 weeks. Researchers will…

This study is creating a detailed database of 150 adults with faecal incontinence, some of whom also have urinary incontinence (double incontinence). Researchers will use questionnaires and a special anal pressure test to compare factors like diarrhea, surgeries, and nerve condit…

This study tests a tool called SWEET that predicts how long an ERCP procedure will take. ERCP is a procedure that uses a camera and X-rays to treat bile duct problems. The tool uses patient and procedure details to estimate time. Researchers will compare its predictions to doctor…

This pilot study tests whether adjusting magnesium levels in dialysis fluid can reduce harmful blood cell activation during treatment. Fifteen adults with kidney failure will try three different dialysis fluid recipes over six weeks. Researchers will measure blood cell counts and…

This study looks at whether women with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause) have different body composition than healthy women. Researchers will use a simple, non-invasive test called bio-electrical impedance to measure fat …

This study looks at whether a breathing test called impulse oscillometry (IOS) can help doctors monitor asthma better than standard tests. Fifty adults with asthma will take IOS and other lung function tests, plus fill out questionnaires, at the start and again 3-6 months after a…

This study follows 100 adults with COPD for one year to see how airway inflammation changes over time. Researchers use a simple breath test (FeNO) and a blood sample to measure inflammation markers. Participants visit the clinic three times—at the start, 6 months, and 12 months—t…

This study is testing whether a continuous glucose monitor (CGM) can predict blood sugar problems in people who are at risk for type 1 diabetes but have no symptoms. Researchers will follow 75 people aged 5 to 39 who have diabetes-related autoantibodies. They will compare CGM dat…