Can a low FODMAP diet soothe IBS even without lactose issues?

NCT ID NCT05120752

Recruiting now Symptom relief Sponsor: Universitair Ziekenhuis Brussel Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether a low FODMAP diet can improve symptoms and quality of life in people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Sixty participants will follow the diet with guidance from a dietitian. The goal is to see if this restrictive diet still helps when lactose digestion is normal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low FODMAP diet
What this could lead to: If successful, this could show that a low FODMAP diet helps ease IBS symptoms even in people without lactose issues, offering a clear dietary option.
What could go wrong: This is a small, early-phase trial with only 60 people. It may not prove effective for everyone, and the restrictive diet can be hard to follow.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME

Contacts and locations

Locations

UZ Brussel
RECRUITING

Jette, Brussels Capital, 1090, Belgium

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