IRRITABLE BOWEL SYNDROME

This study tests whether taking glutamine, an amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in obese patients. 110 participants will receive either glutamine or a protein powder placebo. Researchers will measure changes …

This study tests an online program called REACH for parents who have irritable bowel syndrome (IBS). The goal is to see if the program can help parents encourage healthy habits in their young children and reduce the chance of the kids developing similar stomach problems. About 46…

This Phase 2b study tests camlipixant, an experimental drug, in 420 adults with moderate-to-severe irritable bowel syndrome (IBS) with diarrhea or mixed bowel habits. Participants receive either camlipixant or a placebo for 26 weeks. The main goal is to see if the drug reduces we…

This study tests a 9-week phone-based program called WISH that teaches positive psychology exercises to people with irritable bowel syndrome (IBS). The goal is to see if the program is practical and helpful for improving symptoms. Researchers will compare it to an educational con…

This study tests whether acupuncture can reduce stomach pain in children aged 8-17 with disorders of gut-brain interaction, like irritable bowel syndrome. Half of the 96 participants will get real acupuncture, and half will get a sham (fake) treatment. Researchers will measure pa…

This study tests whether psyllium, a common fiber supplement, can reduce belly pain and bloating in children with irritable bowel syndrome (IBS) who are sensitive to fructans—a type of sugar found in foods like wheat and onions. Researchers will give 110 kids aged 12-17 either ps…

This study tests an injected drug called brenipatide in 342 adults with irritable bowel syndrome with constipation (IBS-C). Participants will receive either the drug or a placebo for about 35 weeks. The goal is to see if brenipatide safely reduces abdominal pain and improves bowe…

This Phase 2 study tests whether brenipatide, given as an injection under the skin, can safely reduce abdominal pain and improve stool consistency in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). About 531 participants will receive either the drug or a placeb…

This study tests whether a daily dose of Skal Pro—a mix of a friendly bacteria (Lactobacillus plantarum 299v) and a prebiotic fiber—can reduce IBS symptoms like belly pain, bloating, and irregular bowel movements. Sixty adults with IBS will receive either the supplement or a dumm…

This study tests whether repeated magnetic pulses to the brain (rTMS) can reduce abdominal pain and diarrhea in people with diarrhea-predominant irritable bowel syndrome (IBS-D). 46 adults will receive either real or sham rTMS for 20 minutes daily over 3 weeks. Researchers will a…

This study is testing whether a fecal transplant from a carefully selected donor can reduce symptoms in people with moderate to severe IBS. The donor stool has low levels of certain proteins that may trigger IBS. 43 participants will receive the transplant during a colonoscopy an…

This study looks at whether regular cardiovascular exercise (like walking, jogging, or cycling) can reduce the severity of irritable bowel syndrome (IBS) symptoms in adults who currently have a sedentary lifestyle. Researchers will enroll 30 participants aged 18-60 with moderate-…

This study tests whether a small, home-use device that gently stimulates a nerve in the ear can help young adults (ages 18-29) manage pain and other symptoms of irritable bowel syndrome (IBS). Eighty participants will use either the active device or a sham (inactive) version twic…

This study compares two different exercise programs combined with dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome. Researchers will enroll 30 adults aged 30 to 65 with moderate to severe IBS and confirmed fibro…

This study compares the DOMINO diet app to the strict low FODMAP diet for easing irritable bowel syndrome (IBS) symptoms. About 110 adults with IBS will use either the app or follow the strict diet. The goal is to see if the app works as well as the standard diet, offering a more…

This study tests whether transplanting gut bacteria from healthy donors can relieve symptoms of irritable bowel syndrome (IBS). 102 adults who haven't responded to at least three standard treatments will receive donor bacteria either in capsules or through a tube into the nose an…

This study tests whether a dietary supplement called DIELEN Protect, which contains glutamine and marine peptides, can ease symptoms of irritable bowel syndrome (IBS). One hundred adults with moderate to severe IBS will take either the supplement or a placebo for 8 weeks. Researc…

This study tests whether taking glutamine, a natural amino acid, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D) who also have increased intestinal permeability (leaky gut). About 60 adults will receive either glutamine or a placebo daily …

This phase 3 trial tests whether a low FODMAP diet can improve symptoms and quality of life in people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Sixty participants will follow the diet with guidance from a dietitian. The goal is …

This study tests whether a daily synbiotic supplement (Vivatlac) can change the gut bacteria of people with irritable bowel syndrome (IBS). Twenty adults with moderate to severe IBS will take either the supplement or a placebo for 12 weeks. Researchers will compare stool samples …

This study tests whether a daily synbiotic (a mix of probiotics and prebiotics) can reduce IBS symptoms like belly pain, bloating, and irregular bowel habits. About 200 adults with moderate-to-severe IBS will take either the synbiotic or a placebo for 36 weeks. The goal is to see…

This study tests whether avoiding foods identified by a skin patch test can improve irritable bowel syndrome (IBS) symptoms. 250 adults with IBS will undergo patch testing for 80 foods and then follow either a true avoidance diet (avoiding foods they are allergic to) or a sham di…

This study tests whether taking oral glutamine, a dietary supplement, three times a day for 12 weeks can reduce chronic stomach pain, bloating, and diarrhea in veterans with Gulf War Illness. Researchers will also check if it helps repair the gut lining. The trial involves 80 vet…

This study at Mayo Clinic tests whether biofeedback therapy and inspiratory muscle training can help people with dyssynergic defecation—a condition where pelvic floor muscles don't relax properly during bowel movements. Two hundred adults aged 18 to 80 with chronic constipation w…

This study tests whether a simple biofeedback technique—teaching people to control their abdominal and chest muscles using a video—can reduce visible bloating after meals. 100 adults with irritable bowel syndrome, dyspepsia, or functional bloating will be randomly assigned to eit…

This study is testing the drug eluxadoline (Viberzi) in children aged 6 to 17 who have irritable bowel syndrome with diarrhea (IBS-D). The goal is to see if it improves stool consistency and is safe for kids. About 95 children will take either the drug or a placebo for 4 weeks, a…

This study is testing whether a single low dose of esketamine, given during a colonoscopy, can reduce symptoms of irritable bowel syndrome (IBS) in adults who also have anxiety or depression. The trial plans to enroll 552 participants and will measure symptom severity and quality…

This study investigates whether a gut infection called Brachyspira causes IBS symptoms by making the immune system overreact to certain foods. Researchers will use advanced imaging to identify which foods trigger reactions in the gut. Participants will eliminate those foods for f…

This study aims to find a marker in stool or urine that can objectively measure whether people with Irritable Bowel Syndrome (IBS) are sticking to their prescribed diet. Researchers will enroll 94 adults with moderate-to-severe IBS and track their food intake and gut symptoms. Th…

This study looks at the gut bacteria of 100 people with irritable bowel syndrome (IBS) to see if a stool test can help diagnose the condition. Half will follow a low-FODMAP diet, a common but restrictive eating plan. Researchers will compare the bacteria and symptoms between the …

This study compares a new orally disintegrating form of Trimedat (trimebutine) to the standard tablet in 36 healthy adults. The goal is to see if the new version is absorbed similarly and is safe. This trial does not treat any disease; it only gathers data on how the drug behaves…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome affects the way the body processes drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation markers and estimate how they mig…

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This study is creating a long-term group of 600 people with irritable bowel syndrome (IBS) to track how the disease changes over time. Participants will fill out questionnaires about their symptoms, quality of life, and habits, and provide stool samples every six months. The goal…

This study is testing a new online food questionnaire to see if it can accurately measure what people eat, including FODMAPs (certain carbs that can cause digestive issues). Researchers will compare the questionnaire to a standard 4-day food diary in 400 adults, both with and wit…

This study looks at whether a simple breath test can tell if people with moderate to severe irritable bowel syndrome (IBS) will feel better on a lactose-free diet. About 90 adults with IBS will take the breath test and then follow a lactose-free diet for 4 weeks. Researchers will…

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to see which bacteria are present and how they change with standard treatment. The goal is to bet…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…