New IBS drug candidate camlipixant enters Mid-Stage trial

NCT ID NCT07519395

Recruiting now Symptom relief Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2b study tests camlipixant, an experimental drug, in 420 adults with moderate-to-severe irritable bowel syndrome (IBS) with diarrhea or mixed bowel habits. Participants receive either camlipixant or a placebo for 26 weeks. The main goal is to see if the drug reduces weekly abdominal pain. The trial also tracks other symptoms like bloating and discomfort.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: camlipixant
What this could lead to: If successful, camlipixant could offer a new treatment option to reduce abdominal pain and other symptoms in people with moderate-to-severe IBS-D and IBS-M.
What could go wrong: This is an early Phase 2b trial, so results may not confirm effectiveness. The drug may cause side effects, and not all participants may benefit. Larger studies are needed before it becomes available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IRRITABLE BOWEL SYNDROME

Contacts and locations

Locations

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Anniston, Alabama, 36207, United States
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Guntersville, Alabama, 35976, United States
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Mobile, Alabama, 36608, United States
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Saraland, Alabama, 36571, United States
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Scottsdale, Arizona, 85260, United States
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Tempe, Arizona, 85284, United States
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Anaheim, California, 92804, United States
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Chula Vista, California, 91910, United States
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Coronado, California, 92118, United States
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Garden Grove, California, 92845, United States
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Lancaster, California, 93534, United States
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Lancaster, California, 93534, United States
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Los Angeles, California, 90015, United States
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Murrieta, California, 92563, United States
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Pasadena, California, 91105, United States
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San Diego, California, 92103, United States
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San Diego, California, 92120, United States
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Sherman Oaks, California, 91403, United States
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West Hills, California, 91307, United States
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Aurora, Colorado, 80012, United States
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Colorado Springs, Colorado, 80907, United States
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Lone Tree, Colorado, 80124, United States
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Brandon, Florida, 33511, United States
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Clearwater, Florida, 33756, United States
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Coral Gables, Florida, 33134, United States
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Doral, Florida, 33126, United States
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Hialeah, Florida, 33016, United States
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Homestead, Florida, 33033, United States
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Jacksonville, Florida, 32258, United States
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Kissimmee, Florida, 34741, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33134, United States
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Miami, Florida, 33144, United States
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Miami, Florida, 33145, United States
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Miami, Florida, 33157, United States
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Miami, Florida, 33165, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33174, United States
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Miami, Florida, 33186, United States
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Miami Beach, Florida, 33141, United States
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Miami Lakes, Florida, 33016, United States
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Miami Springs, Florida, 33166, United States
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New Port Richey, Florida, 34653, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32807, United States
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Orlando, Florida, 32835, United States
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Palm Harbor, Florida, 34684, United States
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Pembroke Pines, Florida, 33024, United States
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Pembroke Pines, Florida, 33026, United States
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Sunrise, Florida, 33351, United States
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Tampa, Florida, 33607, United States
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Tampa, Florida, 33607, United States
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Tampa, Florida, 33613, United States
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Tampa, Florida, 33614, United States
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Atlanta, Georgia, 30328, United States
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Atlanta, Georgia, 30342-5006, United States
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Decatur, Georgia, 30033, United States
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Lawrenceville, Georgia, 30044, United States
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Union City, Georgia, 30291, United States
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Meridian, Idaho, 83646, United States
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Morton, Illinois, 61550, United States
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Oak Lawn, Illinois, 60453, United States
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Ames, Iowa, 50010, United States
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Houma, Louisiana, 70360, United States
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Boston, Massachusetts, 02111, United States
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Flint, Michigan, 48504, United States
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Chesterfield, Missouri, 48038, United States
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Hazelwood, Missouri, 63042, United States
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Missoula, Montana, 59808, United States
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Hartsdale, New York, 10530, United States
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New Windsor, New York, 12553, United States
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New York, New York, 10016, United States
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North Massapequa, New York, 11758, United States
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Richmond Hill, New York, 11418, United States
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Rochester, New York, 14609, United States
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Charlotte, North Carolina, 28210, United States
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Fayetteville, North Carolina, 28304, United States
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Greenville, North Carolina, 27834, United States
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Rocky Mount, North Carolina, 27804, United States
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Salisbury, North Carolina, 28144, United States
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Winston-Salem, North Carolina, 27103, United States
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Beavercreek, Ohio, 45431, United States
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Columbus, Ohio, 43202, United States
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Mentor, Ohio, 44060, United States
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Norman, Oklahoma, 73071, United States
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Tulsa, Oklahoma, 74104, United States
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Harrisburg, Pennsylvania, 17110, United States
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Pittsburgh, Pennsylvania, 15236, United States
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Uniontown, Pennsylvania, 15401, United States
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Chattanooga, Tennessee, 37404, United States
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Chattanooga, Tennessee, 37412, United States
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Johnson City, Tennessee, 37604, United States
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Kingsport, Tennessee, 37663, United States
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Knoxville, Tennessee, 37909, United States
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Nashville, Tennessee, 37211, United States
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Corsicana, Texas, 75110, United States
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Georgetown, Texas, 78628, United States
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Harlingen, Texas, 785500, United States
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Houston, Texas, 77081, United States
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Houston, Texas, 77099, United States
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Mesquite, Texas, 75149, United States
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Missouri City, Texas, 77459, United States
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Pearland, Texas, 77584, United States
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San Antonio, Texas, 78229, United States
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Ogden, Utah, 84403, United States
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Ogden, Utah, 84405, United States
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Sandy City, Utah, 84070, United States
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Lynchburg, Virginia, 24502, United States
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Petersburg, Virginia, 23805, United States
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Richmond, Virginia, 23226, United States

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