IRRITABLE BOWEL SYNDROME

This study tests an internet-based program called REACH for parents with irritable bowel syndrome (IBS) and their young children. The goal is to see if the program helps parents encourage healthy habits in their kids, rather than focusing on illness. About 460 parent-child pairs …

This study tests whether a small, home-used device that stimulates a nerve in the ear can safely help young adults (ages 18–29) manage pain and other symptoms of irritable bowel syndrome (IBS). About 80 participants will use either the active device or a sham version twice daily …

This study looks at whether psyllium, a type of fiber, can reduce belly pain and bloating in children with irritable bowel syndrome (IBS) who are sensitive to fructans (a sugar found in many foods). About 110 kids aged 12-17 will eat a special diet and take either psyllium or a p…

This study is testing whether a single low dose of esketamine can reduce symptoms of irritable bowel syndrome (IBS) in 552 adults aged 18-60 who also have anxiety or depression. Participants will receive the drug during a colonoscopy, and their IBS severity and quality of life wi…

This study tests an experimental drug called brenipatide for adults with irritable bowel syndrome with constipation (IBS-C). About 342 participants will receive either the drug or a placebo injection under the skin for several weeks. The goal is to see if the drug safely improves…

This study looks at whether a low FODMAP diet can improve symptoms and quality of life in people with moderate to severe irritable bowel syndrome (IBS) who do not have lactose malabsorption. Researchers will compare results to a lactose-free diet from a previous study. The goal i…

This study tests whether a daily probiotic supplement called Skål Pro (containing Lactobacillus plantarum 299 and galacto-oligosaccharides) can reduce IBS symptoms like belly pain, bloating, and irregular stools, and improve quality of life and mood. About 60 adults with IBS will…

This study compares two different exercise programs plus dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome (IBS). Thirty adults aged 30 to 65 with moderate to severe IBS and confirmed fibromyalgia will participat…

This study tests whether a fecal transplant from a carefully selected donor can reduce symptoms in people with irritable bowel syndrome (IBS) who have high gut protein breakdown activity. About 43 adults with moderate to severe IBS will receive the transplant during a colonoscopy…

This study compares the DOMINO diet app to the standard low FODMAP diet for people with Irritable Bowel Syndrome (IBS). About 110 adults will use one of the two approaches to see if their symptoms improve. The goal is to ease discomfort, not to cure the condition.

This study tests whether a dietary supplement called DIELEN Protect, made from glutamine and marine peptides, can reduce symptoms like belly pain and bloating in people with irritable bowel syndrome (IBS). About 100 adults with moderate to severe IBS will take the supplement or a…

This study is testing an investigational drug called eluxadoline in children aged 6 to 17 who have irritable bowel syndrome with diarrhea (IBS-D). The goal is to see if the drug can improve stool consistency and reduce symptoms safely. About 95 children will take either the drug …

This study tests whether a dietary supplement called glutamine can reduce chronic stomach pain, diarrhea, and bloating in veterans with Gulf War Illness. Researchers will give glutamine or a placebo to 80 veterans for 12 weeks and track symptom changes. The goal is to find a safe…

This study tests an experimental drug called brenipatide for adults with irritable bowel syndrome with diarrhea (IBS-D). The goal is to see if it safely reduces daily belly pain and improves stool consistency compared to a placebo. About 531 participants will receive injections u…

This study tests whether a daily synbiotic (a mix of probiotics and prebiotics) can reduce IBS symptoms like belly pain, bloating, and irregular bowel habits. About 200 adults with moderate-to-severe IBS will take either the synbiotic or a placebo for 36 weeks. The goal is to see…

This study tests whether avoiding foods identified by a skin patch test can relieve irritable bowel syndrome (IBS) symptoms. Adults with IBS receive painless patches on their back containing 80 different foods or additives. Those with positive reactions are randomly assigned to a…

This study tests whether fecal microbiota transplantation (FMT) can reduce symptoms of irritable bowel syndrome (IBS). About 102 adults with hard-to-treat IBS will receive FMT via oral capsules or a tube once a month for three months. Researchers will track symptom changes, quali…

This study tests a program called WISH, which uses positive psychology exercises (like gratitude and optimism) to help people with irritable bowel syndrome (IBS). Researchers want to see if it's practical and can improve gut-brain communication. About 50 adults with IBS will eith…

This study is testing whether a cardiovascular endurance training program can reduce the severity of irritable bowel syndrome (IBS) symptoms in adults who are sedentary and physically inactive. Researchers will enroll 30 participants aged 18-60 with moderate-to-severe IBS. The go…

This study is testing whether a special supplement called Vivatlac Synbiotic can help people with irritable bowel syndrome (IBS) by changing the bacteria in their gut. About 20 adults with moderate to severe IBS will take either the supplement or a placebo daily for 12 weeks. Res…

This study tests whether taking glutamine, a natural amino acid, can reduce symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D) who also have a 'leaky gut.' About 60 adults will receive either glutamine or a placebo daily for 8 weeks. The goal is to see …

This study tests a simple, drug-free biofeedback technique to reduce visible belly bloating in people with Irritable Bowel Syndrome (IBS) or similar conditions. One hundred adults who experience bloating after meals will be randomly assigned to learn the technique or receive a pl…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study aims to see if a new online food questionnaire can accurately measure what people eat, especially FODMAPs (certain carbs that can cause digestive issues). Researchers will compare the questionnaire to a standard 4-day food diary in 400 adults, including people with and…

This study aims to collect medical information and biological samples (like blood, urine, and stool) from 2000 adults with functional digestive disorders such as irritable bowel syndrome, dyspepsia, and constipation. The goal is to identify markers that could help diagnose these …

This study compares a new melt-in-mouth version of Trimedat (76.95 mg) to the standard tablet (100 mg) in 36 healthy adults. Researchers want to see if the new form is absorbed similarly and is safe. The goal is to offer a more convenient option for people with digestive issues l…

This study looks at whether a simple breath test can predict if a lactose-free diet will reduce symptoms in people with moderate-to-severe Irritable Bowel Syndrome (IBS). Researchers will compare symptom improvement between those who test positive for lactose malabsorption and th…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome can change the way the body processes certain drugs. Researchers will measure inflammation markers and immune cells in blood samples from 150 adults and children with …

This study is following 600 people with Irritable Bowel Syndrome (IBS) over time to learn more about how the condition develops and changes. Researchers will collect information through questionnaires and stool samples. The goal is to better understand IBS, not to test a new trea…

This study looks at the gut bacteria of 40 people with irritable bowel syndrome (IBS) who have constipation and produce high methane. Researchers will collect stool and blood samples to understand the bacteria's role and how they change with standard treatment. The goal is to fin…

This study looks at why some people with Alpha-Gal syndrome get stomach pain, diarrhea, or vomiting after eating pork. Researchers will give 30 adults pork with and without a certain sugar (alpha-gal) in a blinded test to see if it triggers an allergic reaction. They will also me…