Deep gene search aims to uncover why some young people get cancer

NCT ID NCT04141462

Recruiting now Knowledge-focused Sponsor: Centre Georges Francois Leclerc Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at people who developed cancer at a young age (before 40, or before 30 for breast cancer) but had normal results on standard genetic tests. Researchers will use a more advanced technique called exome sequencing to search for new genetic changes that might raise cancer risk. The goal is to find hidden hereditary factors that current tests miss.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could identify new genes linked to early-onset cancer, improving genetic testing and risk assessment for future patients.
What could go wrong: This is an observational study, not a treatment trial. It may not find new genes, and any discoveries would need further validation before helping patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer inherited disease susceptibility neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER GENETIC PREDISPOSITION

Contacts and locations

Locations

CH de Troyes
NOT_YET_RECRUITING

Troyes, France
CHRU Jean Minjoz
NOT_YET_RECRUITING

Besançon, France
CHU de Dijon
NOT_YET_RECRUITING

Dijon, France
CHU de Reims
NOT_YET_RECRUITING

Reims, France
Centre Georges-François Leclerc
RECRUITING

Dijon, 21000, France
Polyclinique de Courlancy
NOT_YET_RECRUITING

Reims, France

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