GENETIC PREDISPOSITION

This study tests whether using a person's genetic risk can help choose the best antifungal medicine to prevent serious mold infections in patients with acute myeloid leukemia (AML) receiving chemotherapy. About 410 adults will be randomly assigned to different prevention strategi…

This study aims to understand why some people who drink alcohol develop liver cancer while others do not. Researchers will analyze DNA from 1,000 participants to find new genetic variants linked to alcohol-related liver cancer. The goal is to create a risk score that could help p…

This study is building a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic, biochemical, and molecular information to identify differences in how the disease presents in women. The goal is to better understand these variations …

This study looks at how parents and children (ages 10-24) communicate after learning the child has a genetic risk for cancer. Researchers want to find out what helps or hinders these conversations, and how they affect the child's emotions and health choices. The goal is to improv…

This study compares two ways of providing pre-test education for cancer genetic testing: a chatbot (called GIA) versus a live genetic counselor. About 96 adults at high risk for certain cancers will be randomly assigned to one of the two methods. The main goal is to see if using …

This study looks at whether a genetic test can help doctors better assess prostate cancer risk and guide treatment. About 3,000 men with or at high risk of prostate cancer will provide DNA samples to check for rare and common genetic changes. The goal is to see if this informatio…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand genetic factors and develop a risk score. The goal is…

This study tests whether applying minoxidil cream (a hair growth treatment) to the breasts for two weeks before surgery can improve blood flow and tissue survival in women undergoing preventive mastectomy and immediate breast reconstruction. Twenty-five women at high genetic risk…

This study is creating a biobank of prostate tissue samples from people with inherited gene mutations that raise their risk for aggressive prostate cancer. Researchers will compare these samples to those from people without such mutations to better understand how the disease deve…

This study aims to improve early detection of pancreatic cancer by following 20,000 people who have a family history of the disease or carry certain gene changes that raise their risk. Participants will be monitored over time to see who develops cancer and how it can be caught so…

This study looks at how a person's genes influence their body's response to oral semaglutide, a medication used for type 2 diabetes. About 125 adults with normal to pre-diabetes blood sugar levels will take the drug for two weeks and have their blood tested after a standardized b…

This study looks for new genetic causes of cancer in people diagnosed at a young age (under 40, or under 30 for breast cancer). Standard genetic tests often miss the cause, so researchers will use a more detailed method called exome sequencing to search for hidden risk factors. T…

This study follows 56 adolescents and young adults with a genetic predisposition to cancer as they leave pediatric care and enter the adult health system. Researchers want to see if these individuals find adult doctors and continue recommended cancer screenings over the next 8 ye…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors up-to-date information about genetic findings. The goal is to see if the tool is easy to use and helps p…

This study aims to learn more about diseases of the heart and blood vessels by collecting medical information and samples from up to 1,000 people. Participants include those with known or suspected genetic vascular conditions, their relatives, and healthy volunteers aged 2 and ol…