GENETIC PREDISPOSITION

This study tests whether using a person's genetic risk can better prevent serious mold infections in patients with acute myeloid leukemia (AML) receiving chemotherapy. About 410 adults will be randomly assigned to different antifungal prevention plans based on their genetic profi…

This study tests whether applying minoxidil (a hair-growth cream) to the breasts for two weeks before surgery can improve blood flow and tissue survival during breast reconstruction. It involves 25 women at high genetic risk for breast cancer who are having both breasts removed a…

This study looks for new genetic causes of cancer in people diagnosed at a young age (under 40, or under 30 for breast cancer). Standard genetic tests often miss the cause, so researchers will use a more detailed method called exome sequencing to search for hidden risk factors. T…

This study looks at how parents and children (ages 10-24) talk about the child's genetic risk for cancer. Researchers want to find out what helps or hinders these conversations. The goal is to improve genetic education and help families take steps to prevent cancer. About 125 fam…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand genetic factors and develop a risk score. The goal is…

This study looks at how a person's genes and their environment (like drinking alcohol) work together to cause liver cancer in people with alcohol-related liver disease. Researchers will study 1,000 participants to find new genetic variants that increase cancer risk. The goal is t…

This study follows 56 adolescents and young adults with a genetic predisposition to cancer as they leave pediatric care and enter the adult health system. Researchers want to see if these individuals find adult doctors and continue recommended cancer screenings over the next 8 ye…

This study is testing a new online platform called Nest for young adults aged 18-39 who have had genetic testing for cancer risk. The platform gives patients and their doctors up-to-date information about genetic findings. The goal is to see if the tool is easy to use and helps p…

This study is building a registry of 100 women who have had a heart attack or unstable angina. Researchers will collect genetic and biological information to better understand how heart disease differs among women. The goal is to identify subtypes that could lead to more personal…

This study compares two ways of providing pre-test education for cancer genetic testing: a chatbot (GIA) versus a genetic counselor. About 96 adults at high risk for certain cancers will take part. Researchers want to see if using a chatbot leads to more people completing genetic…

This study aims to learn more about diseases of the heart and blood vessels by collecting medical information and samples from up to 1,000 people. Participants include those with known or suspected genetic vascular conditions, their relatives, and healthy volunteers aged 2 and ol…

This study looks at whether a genetic test can help doctors better assess prostate cancer risk in men who either have the disease or are at high risk. Researchers will analyze DNA from 3,000 men to find rare and common genetic changes linked to prostate cancer. The goal is to see…

This study is building a collection of prostate tissue samples from 200 people who have genetic mutations that raise their risk for aggressive prostate cancer, along with samples from people without those mutations. Researchers will compare the samples to learn how these genes af…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a drug used for type 2 diabetes. Researchers will give 125 adults with prediabetes the drug for two weeks and measure blood sugar, insulin, and other factors after a test meal.…

This study aims to find better ways to detect pancreatic cancer early in people who are at higher risk due to family history or certain gene changes. Researchers will follow 20,000 volunteers over time to see who develops the disease. The goal is to improve screening and preventi…