Gene test may help prevent deadly fungal infections in leukemia patients

NCT ID NCT03828773

Recruiting now Disease control Sponsor: Bochud Pierre-Yves Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a genetic test can help decide which leukemia patients need a strong antifungal drug (posaconazole) to prevent serious mold infections during chemotherapy. About 410 adults with acute myeloid leukemia will be randomly assigned to receive the drug or a placebo, and their genetic risk will be used to guide treatment. The goal is to see if this personalized approach reduces infections without unnecessary side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Posaconazole (Noxafil), an antifungal drug
What this could lead to: If successful, this could show that using a genetic test to decide who gets antifungal prevention reduces dangerous mold infections in leukemia patients.
What could go wrong: This is an early-stage trial with 410 participants, so results may not apply to all patients. The drug can have side effects like liver issues or drug interactions.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia aspergillosis candidiasis fungal infectious disease inherited disease susceptibility refractory anemia with excess blasts in transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA ASPERGILLOSIS CANDIDIASIS FUNGAL INFECTION GENETIC PREDISPOSITION

Contacts and locations

Locations

AZ Sint-Jan Hospital
RECRUITING

Bruges, 8000, Belgium
Cantonal Hospital Aarau
RECRUITING

Aarau, Aarau, 5001, Switzerland
Cantonal Hospital HFR
RECRUITING

Fribourg, Canton of Fribourg, 1708, Switzerland
Ghent University Hospital
TERMINATED

Ghent, Belgium, 9000, Belgium
Henri Mondor Hospital
RECRUITING

Créteil, Île-de-France Region, 94010, France
University Hospital Basel
RECRUITING

Basel, Basel, 4031, Switzerland
University Hospital Leuven (UZ Leuven)
RECRUITING

Leuven, 3000, Belgium
University Hospital of Geneva (HUG)
RECRUITING

Geneva, Canton of Geneva, 1211, Switzerland
University Hospital of Lausanne / Centre Hospitalier Universitaire Vaudois (CHUV)
RECRUITING

Lausanne, Canton of Vaud, 1011, Switzerland

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