Massive study aims to unlock secrets of rare vascular diseases

NCT ID NCT03538639

Recruiting now Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future treatments. Participants will undergo various tests like scans, blood draws, and heart function assessments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could improve diagnosis and understanding of rare vascular diseases, potentially paving the way for future treatments.
What could go wrong: This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results depend on participant enrollment and data quality.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

inherited disease susceptibility Undiagnosed Diseases vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENETIC MUTATIONS GENETIC PREDISPOSITION VASCULAR DYSFUNCTION

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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