Could your surroundings trigger a hidden genetic risk?

NCT ID NCT04481152

Completed Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study investigates whether environmental and occupational exposures influence the risk of developing tumors in people who carry an SDHx gene mutation. Researchers will compare two groups of mutation carriers: those who have had a tumor and those who have not. The goal is to test the feasibility of a larger study that could one day help identify modifiable risk factors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this pilot could pave the way for a larger study that identifies environmental triggers for tumors in SDHx mutation carriers, potentially leading to prevention advice.
What could go wrong: This is a small pilot feasibility study, not designed to prove cause and effect. It may not yield clear answers about environmental risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary pheochromocytoma-paraganglioma inherited disease susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENVIRONMENTAL EXPOSURE GENETIC PREDISPOSITION SDH GENE MUTATION

Contacts and locations

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Locations

Hôpital européen Georges-Pompidou

Paris, 75015, France

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