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Could your surroundings trigger a hidden genetic risk?

NCT ID NCT04481152

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study investigates whether environmental and occupational exposures influence the risk of developing tumors in people who carry an SDHx gene mutation. Researchers will compare two groups of mutation carriers: those who have had a tumor and those who have not. The goal is to test the feasibility of a larger study that could one day help identify modifiable risk factors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this pilot could pave the way for a larger study that identifies environmental triggers for tumors in SDHx mutation carriers, potentially leading to prevention advice.
What could go wrong
This is a small pilot feasibility study, not designed to prove cause and effect. It may not yield clear answers about environmental risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

101 people

The number who actually took part.

Started

Mar 2022

Finished

Jul 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

50 cases and 50 controls will be enrolled in a single referral center where they are regurlarly managed and followed for a SDHx-related tumor risk. They will be matched on their date of birth

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor 2. Controls: SDHx mutation carriers with no SDHx-related tumor Exclusion Criteria: Incapacity to exercise free and informed consent for the study

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Conditions

The condition(s) this trial relates to.

hereditary pheochromocytoma-paraganglioma inherited disease susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Environmental exposure Genetic predisposition SDH gene mutation

Contacts and locations

Locations

  • Hôpital européen Georges-Pompidou

    Paris, 75015, France

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