Personalized dosing for kids with dystonia? new study investigates genetic factors
NCT ID NCT06554288
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing how the drug trihexyphenidyl is processed in the bodies of 40 children aged 5-17 with dystonic cerebral palsy. Researchers want to see if a child's genetic makeup changes how the drug works, which could help create personalized dosing plans. Participants will take the drug for 15 weeks, and the study will measure drug levels, side effects, and how well dystonia symptoms are controlled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trihexyphenidyl
- What this could lead to
- If successful, this could lead to personalized dosing guidelines for trihexyphenidyl in children with dystonia, improving treatment effectiveness and safety.
- What could go wrong
- This is an early Phase 1 study with only 40 participants, so results may not apply to all children. The focus is on understanding drug metabolism, not on proving the drug works.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Mercy Hospital Kansas City
RECRUITINGKansas City, Missouri, 64108, United States
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