DYSTONIA

This study is testing whether a gentle, focused ultrasound beam can safely calm overactive brain areas in people with movement disorders like Parkinson's or essential tremor, and conditions like epilepsy or addiction. Researchers will measure changes in brain activity and symptom…

This study aims to see if recordings of brain activity from an implanted device can help doctors program deep brain stimulation (DBS) more effectively for people with dystonia. Researchers will compare the standard programming method to a new approach guided by these brain signal…

This study aims to learn more about how deep brain stimulation (DBS) surgery helps control symptoms of Parkinson's disease, essential tremor, and dystonia. Researchers will observe 200 adults with these movement disorders who are having the standard DBS surgery. During the operat…

This study is testing a new daily pill called VIM0423 for adults with isolated dystonia, a movement disorder causing painful, twisting muscle contractions. About 100 participants will take either the real pill or a placebo for 16 weeks to see if it safely reduces symptoms and imp…

This study is collecting real-world information about how well an approved deep brain stimulation device works for people with dystonia. Researchers will follow 300 participants who receive the implanted device to measure symptom reduction and quality of life improvements. The st…

This study aims to collect long-term safety and effectiveness data on Abbott's deep brain stimulation (DBS) systems. It will follow 1,000 patients with Parkinson's disease, essential tremor, or dystonia for five years after their device is implanted and programmed. The goal is to…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The goal is to see if this tool can make diagnosis faster and more accurate, as current methods often lead to misdiagnosi…

This study aims to collect real-world results from a procedure that uses targeted heat (radiofrequency ablation) to treat the brain. It involves 200 people with movement disorders like Parkinson's disease, dystonia, or essential tremor. The main goal is to see how the procedure a…

This study is testing whether deep brain stimulation (DBS) can help reduce muscle stiffness and improve movement in people who have had a stroke. Researchers will implant a small device in the brain and test different stimulation settings during rehabilitation. The trial involves…

This study aims to understand how alcohol affects shaking in people with different tremor conditions like essential tremor, dystonia, and Parkinson's disease. Participants will drink either an alcoholic beverage or a non-alcoholic placebo on separate days while researchers measur…

This study aims to understand how deep brain stimulation (DBS) affects brain networks in people with dystonia. Researchers will observe 15 patients who already have DBS implants that can record brain signals. The study involves brain scans and measurements to learn how DBS change…

This study aims to see if analyzing how a person walks before surgery can help predict how well Deep Brain Stimulation (DBS) will work for their dystonia. Researchers will use wearable sensors to measure walking patterns in 50 patients scheduled for DBS surgery. They will then ch…

This study aims to understand how brain networks change in children with dystonia, a movement disorder that causes involuntary muscle contractions. Researchers will measure brain and muscle activity in 75 children, including some with deep brain stimulation devices, to see how th…

This study aims to learn how to better adjust deep brain stimulation (DBS) therapy for people with dystonia, a severe movement disorder. Researchers will monitor patients' brain signals for one year using a special pacemaker that can also record activity. The goal is to find patt…

This study aims to understand how well deep brain stimulation (DBS) works in everyday practice for people with Parkinson's disease, essential tremor, or dystonia. Researchers will look back at the medical records of up to 5,000 people who have already had or are eligible for the …

This study aims to understand how voice problems occur in people with dystonia or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers will measure brain activity while participants speak during surgery to see how DBS affects voice cont…

This study aims to understand how often functional neurological disorders (FND) occur in people who already have movement disorders like Parkinson's or tremor. Researchers will examine 216 patients to identify the frequency and characteristics of these overlapping symptoms. The g…

This study aims to understand how deep brain stimulation (DBS), a treatment for Parkinson's movement symptoms, affects sleep. Researchers will monitor brain activity and sleep patterns in 64 Parkinson's patients who have or will receive a DBS device. The goal is to learn about th…

This study aims to understand how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity from 80 participants while they perform speech tasks during deep brain stimulation surgery. The goal is to learn h…