DYSTONIA

This study tested an experimental drug called dipraglurant in 15 adults with blepharospasm, a condition causing uncontrollable eyelid spasms. Participants took either 50 mg, 100 mg, or a placebo for a short time. The goal was to see if the drug is safe and can reduce spasm severi…

This study tested whether taking zinc by mouth every day is safe and doable for people with GNAO1-related disorders, a rare genetic condition causing movement problems, seizures, and developmental delays. Thirteen participants aged 6 months to 30 years took zinc for 6 months. Res…

This study looked at how the brain controls movement in adults with conditions like Parkinson's disease, Tourette's syndrome, and dystonia, compared to healthy volunteers. It used brain scans and other tests to gather information, but did not provide any treatment. The goal was t…

This study tested how accurately a robot called Neuromate, using its Neurolocate system, can target specific brain areas during deep brain stimulation surgery. Researchers compared the robot's aimed point to the actual point reached in 18 patients with Parkinson's disease, dyston…

This study looked at how dystonia affects thinking, memory, and mood, not just movement. Researchers tested 102 adults with dystonia using cognitive exams and brain scans. The goal was to better understand the non-motor symptoms of the condition, without offering any treatment.

This study looked at how the cerebellum, a part of the brain, influences learning and movement control in people with dystonia (a movement disorder) and healthy volunteers. Researchers used mild brain stimulation to temporarily change cerebellar activity and measured its effect o…

This study aimed to learn more about why people have tremors by observing brain activity and movement in 85 adults with tremor conditions like Parkinson's disease or essential tremor, as well as healthy volunteers. Participants underwent tests such as MRI scans, brain wave record…

This study looked at how people with dystonia, essential tremor, or Parkinson's disease adapt their eye movements compared to healthy volunteers. Researchers measured changes in eye movement speed and accuracy before and after a task. The goal was to learn more about how the cere…

This study used brain scans to learn why a brain chemical called acetylcholine doesn't work properly in people with dystonia, a condition that causes muscles to twist or turn on their own. Researchers compared 31 adults with dystonia to healthy volunteers using MRI and PET scans.…

This study looked at how two parts of the brain—the cerebellum and the striatum—talk to each other in people with certain genetic forms of dystonia, a movement disorder. Researchers used MRI scans and mild brain stimulation to compare patients with healthy volunteers. The goal wa…