DYSTONIA

This study looks at deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve with other treatments. DBS uses a device like a pacemaker to send electrical signals to parts of the brain that control movement, helpi…

This study tracks how well a commercially available deep brain stimulation system (Vercise) works for people with dystonia, a movement disorder causing muscle spasms. Researchers will follow 300 participants aged 7 and older to measure symptom reduction using standard rating scal…

This study follows 1000 people with movement disorders like Parkinson's disease, essential tremor, and dystonia who receive an Abbott deep brain stimulation (DBS) system. Researchers will measure changes in movement symptoms and track any serious side effects for up to 5 years. T…

This study tests if deep brain stimulation (DBS) can help people with long-term muscle stiffness and movement problems after a stroke. Twelve adults who had a stroke 9-36 months ago will have a small device implanted to stimulate a specific brain area. They will try three differe…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. Researchers will stu…

This study tests whether VIM0423 can reduce dystonia symptoms like muscle spasms and improve quality of life. About 100 adults with isolated dystonia affecting at least two body areas will receive either the drug or a placebo. The trial is double-blind, meaning neither participan…

This study tests if walking patterns measured by wearable sensors before surgery can predict how well deep brain stimulation (DBS) will work for people with dystonia, a movement disorder. Fifty adults scheduled for DBS will wear sensors to record their gait, then be followed afte…

This study looks at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants will receive either an alcoholic drink or a non-alcoholic placebo on two separate days. Researchers will measure tremor changes using a device and c…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Researchers will monitor brain activity and sleep quality in 64 adults who already have or will get a DBS device. The goal is to understand which brain circuits are involved in …

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study tracks brain activity in 25 people with dystonia who are getting deep brain stimulation (DBS). Researchers want to find brain signals that show how well the treatment is working, so therapy can be adjusted faster and more precisely. Participants will use a special pace…

This study aims to find out how common functional neurological disorders are in people who already have a movement disorder like Parkinson's disease, tremor, or dystonia. Researchers will examine 216 adults aged 18 to 80 using neurological exams, thinking tests, and questionnaire…

This study is creating a shared database of children who have had deep brain stimulation (DBS) for conditions like dystonia, epilepsy, or Tourette syndrome. By collecting information from multiple hospitals, researchers hope to learn which children benefit most, which brain targe…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with dystonia, a movement disorder. Researchers will use brain scans and electrical recordings from the brain to understand changes over time. The goal is to learn more about the condition and p…

This study is gathering information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are already scheduled to receive radiofrequency (RF) ablation as part of their routine care. The goal is to see how this treatment affects qua…

This study tests whether brain signals recorded from a deep brain stimulation (DBS) device can help doctors fine-tune settings for people with dystonia, a movement disorder. About 25 adults who are already scheduled for DBS surgery will take part. Researchers will compare standar…

This study observes brain activity related to speech in 80 people with Parkinson's disease, essential tremor, or dystonia who are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record electrical signals from brain regions involved in speech while par…

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …

This study looks at how the brain controls movement in children with dystonia, a condition that causes muscle spasms and twisting. Researchers will use noninvasive tests like EEG to measure brain activity at rest and during simple tasks. Some children with deep brain stimulation …

This study will review the medical records of up to 5,000 people who have or are eligible for deep brain stimulation (DBS) to treat Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in everyday medical practice. N…