Scientists probe brain during surgery to unlock Parkinson's hidden symptoms

NCT ID NCT04735458

Recruiting now Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study records brain activity during deep brain stimulation (DBS) surgery in 140 people with Parkinson's disease or essential tremor. Researchers aim to understand brain networks linked to non-motor symptoms like depression, attention problems, and slow thinking. Participants perform simple computer tasks during surgery while electrodes on the brain surface measure activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help doctors better understand and treat non-motor symptoms like depression and attention problems in Parkinson's disease.
What could go wrong: This is an early-stage observational study, not a treatment trial. It may not lead to direct benefits for participants, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dystonic disorder essential tremor Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE

Contacts and locations

Locations

University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States

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