Can your DNA predict how you respond to a diabetes drug?

This study investigates how different genetic pathways affect the body's response to food and to a short course of orforglipron, an oral GLP-1 drug used for weight management and blood sugar control. Researchers will enroll about 100 adults, with or without type 2 diabetes, who are not on more than two oral diabetes medications. Participants will undergo detailed metabolic tests, including meal challenges, to measure glucose and insulin responses, aiming to uncover subtypes of diabetes and personalize treatment approaches.