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Your DNA could determine if your birth control works

NCT ID NCT06334315

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study investigates whether genetic differences influence how the body breaks down hormones in combined oral contraceptive pills, potentially affecting their ability to prevent pregnancy and the side effects experienced. Researchers will give participants a specific birth control pill (desogestrel/ethinyl estradiol) and measure hormone levels, ovarian activity, and side effects. The goal is to understand why the same pill can work differently for different people.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combined oral contraceptive pill containing desogestrel and ethinyl estradiol
What this could lead to
If successful, this could help personalize birth control prescriptions based on a person's genetics, improving effectiveness and reducing side effects.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly lead to a new drug or cure. Results may not apply to all populations or contraceptive types.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONTRACEPTION PHARMACOGENOMIC DRUG INTERACTION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Colorado Anschutz Medical Campus

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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