Huge canadian study tracks rare cancer mutations to improve treatment

NCT ID NCT04151342

Recruiting now Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting information from 5,500 Canadian cancer patients whose tumors have rare genetic changes. Researchers want to see how well current targeted drugs work for these uncommon mutations. Participants are observed over time, and their treatment outcomes, side effects, and quality of life are tracked. The goal is to learn more about these rare cancers and help guide future treatment choices.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better match rare genetic changes in tumors with the right targeted drugs, improving treatment decisions for future patients.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test new therapies. Results may take years and might not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer Congenital Abnormalities neoplasm Neoplasms, Second Primary therapy-related myeloid neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CANCER, THERAPY-RELATED GENE FUSION GENETIC ALTERATION MALIGNANCIES MULTIPLE MALIGNANT SOLID TUMOR MOLECULAR SEQUENCE VARIATION RAS (KRAS OR NRAS) GENE MUTATION RECEPTOR TYROSINE KINASE GENE MUTATION RTK FAMILY GENE MUTATION

Contacts and locations

Locations

Allan Blair Cancer Centre
NOT_YET_RECRUITING

Regina, Saskatchewan, Canada
BC Cancer
RECRUITING

Vancouver, British Columbia, Canada
CancerCare Manitoba/University of Manitoba
RECRUITING

Winnipeg, Manitoba, Canada
Centre hospitalier de l'Université de Montréal (CHUM)
RECRUITING

Montreal, Quebec, Canada
Centre hospitalier de l'université de Québec - Université Laval
NOT_YET_RECRUITING

Québec, Quebec, Canada
Centre hospitalier universitaire de Sherbrooke (CHUS)
RECRUITING

Sherbrooke, Quebec, Canada
Cross Cancer Institute, University of Alberta - Alberta Health Services
NOT_YET_RECRUITING

Edmonton, Alberta, Canada
Dr. Everett Chalmers Regional Hospital
RECRUITING

Fredericton, New Brunswick, Canada
Dr. H. Bliss Murphy Cancer Centre
NOT_YET_RECRUITING

St. John's, Newfoundland and Labrador, Canada
Hamilton Health Sciences - Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, Canada
Health Sciences North
RECRUITING

Greater Sudbury, Ontario, Canada
Hôpital du Sacré-Coeur-de-Montréal (HSCM)
RECRUITING

Montreal, Quebec, Canada
Institut Universitaire de Cardiologie et de Pneumologie de Québec
NOT_YET_RECRUITING

Québec, Quebec, Canada
Jewish General Hospital
RECRUITING

Montreal, Quebec, Canada
Kingston Health Sciences Centre (KHSC)
RECRUITING

Kingston, Ontario, Canada
Lawson Health Research Institute - London Health Sciences Centre
RECRUITING

London, Ontario, Canada
McGill University Health Centre
NOT_YET_RECRUITING

Montreal, Quebec, Canada
Mount Sinai Hospital
RECRUITING

Toronto, Ontario, Canada
Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, Canada
Princess Margaret Cancer Centre (PMCC) - University Health Network (UHN)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Queen Elizabeth II (QEII) Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, Canada
Saskatoon Cancer Centre
NOT_YET_RECRUITING

Saskatoon, Saskatchewan, Canada
St. Mary's Hospital Center
NOT_YET_RECRUITING

Montreal, Quebec, Canada
Sunnybrook Research Institute - Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, Canada
Thunder Bay Regional Health Sciences Centre
NOT_YET_RECRUITING

Thunder Bay, Ontario, Canada
Tom Baker Cancer Centre - University of Calgary - Alberta Health Services
RECRUITING

Calgary, Alberta, Canada
William Osler Health System - Brampton Civic Hospital
RECRUITING

Brampton, Ontario, Canada

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