Scientists hunt for hidden cancer clues in families

NCT ID NCT05350761

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 4 times

Summary

This study aims to learn how genes and the environment contribute to rare tumors and cancer risk in individuals and families. Researchers will collect medical histories, genetic samples, and health data from up to 500 participants of all ages. No treatment is given; the goal is to better understand cancer's natural history and identify inherited risk factors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could identify new cancer susceptibility genes and clarify how genes and environment interact to cause cancer, potentially guiding future prevention or screening strategies.
What could go wrong: This is an observational study with no treatment, so it won't directly help participants. Results may take years and might not lead to immediate clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer hereditary neoplastic syndrome inherited disease susceptibility neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER ENVIRONMENT GENETIC PREDISPOSITION TO CANCER HEREDITARY NEOPLASMS

Contacts and locations

Locations

NIH National Cancer Institute - Shady Grove
RECRUITING

Rockville, Maryland, 20850, United States
National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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