Could a common psychiatric drug ease chemo vomiting in kids?

NCT ID NCT03118986

Recruiting now Symptom relief Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding olanzapine to standard anti-nausea medicines can better control vomiting in children receiving strong chemotherapy. About 200 children will be randomly assigned to get either olanzapine or a placebo. The goal is to see if olanzapine helps more kids avoid vomiting and the need for extra rescue medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: olanzapine
What this could lead to: If it works, this could give children a more effective, cheap, and safe option to prevent vomiting during cancer treatment.
What could go wrong: This is a Phase 2 trial, so it's still early. Olanzapine may not work better than placebo, and side effects like drowsiness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid system neoplasm Nausea neoplasm Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC SYSTEM--CANCER NAUSEA ONCOLOGY VOMITING IN INFANTS AND/OR CHILDREN

Contacts and locations

Locations

All India Institute of Medical Sciences
RECRUITING

New Delhi, National Capital Territory of Delhi, 110029, India
Cancer Care Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Centre Hospitalier Universitaire Sainte-Justine,
TERMINATED

Montreal, Quebec, H3T 1C5, Canada
Columbia University/Morgan Stanley Children's Hospital
WITHDRAWN

New York, New York, 10032, United States
Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
The Children's Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
University of California
RECRUITING

San Francisco, California, 94158, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599-7220, United States

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