ONCOLOGY

This early-phase study tests an experimental oral drug called NST-628 in adults with advanced solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 230 partic…

This early-stage trial tests an experimental oral drug called TRE-515 in adults with advanced solid tumors that no longer respond to standard treatments. The drug works by blocking a protein cancer cells need to make DNA, potentially slowing their growth. The main goals are to ch…

This early-phase trial is testing a new imaging agent (GEH200520/GEH200521) that lights up on PET scans to help see solid tumors. In Part A, 50 adults with advanced solid tumors will receive the agent and have scans to check safety and how the agent spreads in the body. Part B wi…

This study tests whether a special solution (taurolidine) placed inside the catheter can prevent infections better than the standard saltwater solution. About 148 children with cancer who need a central catheter will take part. The goal is to see if the taurolidine lock reduces t…

This study is testing whether a low dose of olanzapine, a drug usually used for mental health conditions, can prevent or treat the loss of appetite and weight that often happens in cancer patients receiving chemotherapy. About 100 adults with stomach or ovarian cancer will take t…

This study tests a new type of ureteric stent designed to cause fewer blockages, infections, and less pain than standard stents. About 50 adults who have had stents before for kidney stones or cancer will try the new stent. The goal is to see if it reduces complications and the n…

This study tests whether a simple card game, the Go Wish Game, can help people with advanced blood cancers or solid tumors discuss their end-of-life priorities with doctors. About 75 patients will use the cards to sort what matters most to them, then complete an advance care plan…

This study tests whether an internet-based parent-child interaction therapy (I-PCIT) can help improve behavior in children aged 2-12 who have or had cancer. Parents of 300 children will be randomly assigned to start therapy right away or wait 5-6 months. The goal is to see if the…

This study compares two approaches to early palliative care for people with advanced cancer. In one group, everyone gets a referral to palliative care. In the other, referrals happen only when patients report moderate-to-severe symptoms through an online screening tool. The goal …

This study is testing whether giving several common cancer immunotherapy drugs over a shorter time is safe. It involves 776 adults starting treatment with drugs like nivolumab or pembrolizumab. Infusion times will be gradually shortened if patients tolerate it well, and researche…

This study tests whether specially adapted beauty sessions (onco-esthetics) can help people with head and neck cancer feel better about their changed appearance after treatment. Fifty-five patients will receive three sessions, and researchers will measure how their self-image cha…

This study tests a non-drug light treatment called photobiomodulation to see if it can improve memory and thinking problems (chemobrain) in women who had chemotherapy for breast cancer. About 200 women who finished chemo within the past year and have ongoing cognitive complaints …

This study tests whether using a goal-setting tool (Goal Attainment Scale) helps children and teens with cancer maintain their physical abilities during a stem cell transplant hospital stay. About 176 participants aged 6 months to 18 years will be randomly assigned to either stan…

This study tests whether using a walking platform every day after cancer surgery helps patients aged 65 and older regain their normal walking speed by the time they leave the hospital. Sixty participants will do short walking sessions starting the day after surgery. The goal is t…

This study tests whether adding olanzapine to standard anti-nausea medicines can better control vomiting in children receiving strong chemotherapy. About 200 children will be randomly assigned to get either olanzapine or a placebo. The goal is to see if olanzapine helps more kids…

This study tests a mobile app designed to help children aged 9 to 16 who have recently finished cancer treatment manage their symptoms. The app provides educational materials and real-time support, plus personalized help from a nurse. Researchers want to see if using the app for …

This study is testing a new technique called EXPEL to find biomarkers for pancreatic cancer. Researchers will analyze the fluid used to preserve biopsy samples from 200 patients with suspected pancreatic cancer. The goal is to identify proteins and other molecules that could help…

This study works with cancer survivors and their loved ones living in poor areas to improve their diet and physical activity. Researchers will adapt existing health programs to fit the community's needs. About 100 participants from the Birmingham area will track their eating, exe…

This study is testing a new safety tool for cancer patients on chemotherapy. Patients wear a wristband with a QR code. If they go to the emergency room, doctors can scan the code and quickly fill out a checklist about possible serious side effects. The goal is to see if this help…

This study follows 1,538 cancer patients in China to see how their nutritional status affects how well they handle chemotherapy and radiation, their quality of life, and how long they live. Researchers will track changes in diet, weight, and blood markers over time. The goal is t…

This study is testing a new AI tool that creates patient-friendly summaries of radiology reports for people with cancer. The goal is to see if these easy-to-read summaries help patients better understand their scan results and reduce the number of questions doctors receive. About…

This study tests a program called CTNow, which uses educational videos for patients and workshops for doctors to help rural cancer patients in Hawaii learn about and access clinical trials. About 50 patients and their providers will take part. The goal is to see if the program in…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make informed treatment choices. About 1,020 participants will be randomly assigned to use the tool or receive standard information. T…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is collecting short video and voice recordings from 200 cancer patients—some in pain, some not—to create a secure database. The goal is to provide raw material for future artificial intelligence tools that could automatically assess pain from facial expressions and spe…

This observational study tracks 500 lung cancer patients receiving a second round of high-dose radiation to the chest. Researchers will collect data on side effects and survival to find safer ways to deliver repeat radiation. The goal is to help doctors personalize treatment and …

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study explores how a program that helps cancer patients with money problems (like paying for treatment or basic needs) affects their stress, quality of life, and emotional health. Researchers will look at data from about 40 patients and staff at a cancer clinic. The goal is …

This study looks at how people with advanced cancer feel about stopping or reducing medications that may no longer help. Researchers will interview about 25 patients and survey 300 more to understand their attitudes and beliefs. The goal is to learn what factors influence their v…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long-term. Researchers want to know if they get pregnant naturally, use stored eggs or tissue, or decide not to have children. The goal is to improve support and care for femal…

This study looks at how well people tolerate a new blended tube feed over 28 days. It includes up to 50 children and adults who need tube feeding due to conditions like cerebral palsy or cancer. Researchers will track gut symptoms and how much of the formula is taken each day.

This study looks at how steep head-down position and two types of anesthesia (total IV vs. balanced) change eye pressure in women having robotic surgery for gynecologic cancer. Researchers will measure eye pressure in 40 participants to see which anesthesia method causes less pre…

This study aims to understand why some cancer patients develop autoimmune side effects when treated with immune checkpoint inhibitors. Researchers will analyze blood cells and genetics from 600 participants to identify features linked to these side effects. The goal is to improve…

This study is gathering information from 15,000 cancer patients registered on the ROC platform across multiple centers. The goal is to track how quickly patients move through diagnosis, treatment decisions, and care, and to identify where delays or extra costs occur. No new treat…

This study follows 200 cancer patients starting immunotherapy (checkpoint inhibitors) to understand why some develop immune-related side effects. Researchers will collect blood samples and clinical data to find early warning signs. The goal is to improve how doctors monitor and m…

This study tracks 3,000 cancer patients taking oral anticancer drugs at home. Researchers want to see how well the drugs work in real life and what problems arise. The goal is to improve monitoring and coordination between hospitals and local doctors.