ONCOLOGY

This early-stage study tests an experimental oral drug, NST-628, in adults with advanced solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it shrinks tumors. About 230 participants w…

This early-stage trial tests an experimental pill called TRE-515 in people with advanced solid tumors that have not responded to standard treatments. The drug works by blocking a key enzyme cancer cells need to make DNA, potentially slowing tumor growth. The main goals are to fin…

This study is testing a new imaging agent (GEH200520/GEH200521) that uses a PET scan to take pictures of solid tumors. In the first part, researchers check the safety of the agent in 50 adults with advanced cancer. In the second part, they use the agent to see if tumors change af…

This study tests whether a taurolidine lock solution, placed inside the catheter after each use, can prevent infections better than a standard saline lock. The trial involves 148 children and young adults with cancer who need a central catheter. Participants are randomly assigned…

This study looks at how well people with conditions like cerebral palsy or cancer tolerate a new blended tube feed. Up to 50 participants will use the feed for 28 days, and researchers will track symptoms like reflux, vomiting, and diarrhea. The goal is to see if the feed is easy…

This study tests whether a simple card game, called the Go Wish Game, can help people with advanced blood cancers or solid tumors talk about their end-of-life wishes with their doctors. About 75 adults with a life expectancy of more than 3 months will play the game and then compl…

This study tests a new type of ureteric stent designed to cause fewer blockages, infections, and pain than standard stents. About 50 adults who have had stents before for kidney stones or cancer will try the new stent. The goal is to see if it reduces complications and the need f…

This study tests whether using a walking platform every day helps people aged 65 and older regain their normal walking speed after cancer surgery. Researchers will compare how many patients recover their pre-surgery walking ability by the time they leave the hospital. The goal is…

This study tests a mobile health app designed to help children ages 9-16 who recently finished cancer treatment manage symptoms like fatigue, anxiety, and pain. About 150 children and their primary caregivers will use the app with personalized nurse support for 12 weeks. The goal…

This study tests a program to help cancer survivors and their caregivers in low-income areas eat healthier and be more active. About 100 adults aged 18-89 who have had cancer or are close to a survivor can join. The program adapts proven health tips to fit each person's life and …

This study looks at whether adapted oncoesthetics (special beauty care) can help people with head and neck cancer feel better about their appearance after harsh treatments. About 55 adults starting cancer therapy will receive early oncoesthetics. The goal is to see if this approa…

This study tests if a telehealth program called I-PCIT can help parents manage disruptive behavior in children aged 2-12 who have or had cancer treatment. About 300 families will either get the therapy right away or wait 5-6 months. The goal is to see if the program is practical …

This study tests a light-based treatment called photobiomodulation to see if it can improve memory and thinking problems (chemobrain) in women who had chemotherapy for breast cancer. About 200 women who finished chemo less than a year ago and still have cognitive complaints will …

This study looks at whether giving certain cancer immunotherapy drugs over a shorter time is still safe. About 776 adults starting treatment with drugs like nivolumab or pembrolizumab will have their infusion times gradually shortened if they tolerate it well. The main goal is to…

This study tests whether adding olanzapine, a safe and inexpensive drug already used in children for other conditions, to standard anti-nausea medicines can better control vomiting in children receiving strong chemotherapy. About 200 children with cancer or undergoing stem cell t…

This study compares two ways of providing early palliative care to people with advanced cancer. In one group, everyone sees a specialist. In the other, only those with moderate-to-severe symptoms get a referral. The goal is to see if the targeted approach works just as well for q…

This study tests whether using a goal-setting tool helps children and teens maintain their physical abilities during a stem cell transplant. About 176 participants will be randomly assigned to either standard care or a program that sets personalized functional goals. The aim is t…

This study looks at how people with advanced cancer feel about stopping medicines they may no longer need. Many patients take multiple drugs, which can cause side effects and lower quality of life. Researchers will interview about 325 patients and use questionnaires to understand…

This study tests a program called CTNow that helps cancer patients and doctors in rural areas learn more about clinical trials. The program uses education and teleconference tools to make it easier for patients to find and join trials. About 50 adults with cancer from Hawaii, Kau…

This study follows 1,538 cancer patients in China to see how their nutritional status affects their response to chemotherapy and radiation. Researchers will track changes in diet, weight, and quality of life over time. The goal is to find ways to use nutrition to improve treatmen…

This study explores how a financial navigation program helps cancer patients deal with money problems caused by their treatment. Researchers will look at patient surveys and medical records to see if the program reduces financial hardship, improves quality of life, and eases emot…

This study gathers information from 15,000 cancer patients to see how well the healthcare system works. It looks at how quickly patients get diagnosed, treated, and supported. No new drugs or treatments are given. The goal is to find ways to make cancer care faster and more effic…

This study tests a new model called B-COMPASS that uses a 22-question survey to predict how well patients will follow their treatment plans. About 3100 adults with heart disease, diabetes, immune disorders, nerve conditions, cancer, or rare diseases will take part across Europe. …

This study is for people with lung or chest cancers that have come back or are new, and who have already had radiation before. Researchers want to see how safe and effective a second round of high-dose radiation is by tracking side effects and survival in 500 participants. The go…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long-term. Researchers want to know if women later get pregnant naturally, use stored eggs or tissue, or decide not to have children. The goal is to improve care and support fo…

This study tests a special tool called UR-GOAL that helps older adults (age 60+) with newly diagnosed acute myeloid leukemia and their caregivers make treatment decisions. About 1,020 participants will be randomly assigned to use the tool or receive general health information. Th…

This study is testing a tool that uses artificial intelligence to turn complex radiology reports into simple, patient-friendly summaries. About 2,000 adults with cancer will receive these summaries through their online patient portal. Researchers want to see if this helps patient…

This study aims to understand why some cancer patients develop autoimmune problems after receiving a type of immunotherapy called checkpoint inhibitors. Researchers will analyze blood samples and health records from 600 adults with cancer who are prescribed these drugs. The goal …

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study looks at how body position and the type of anesthesia used during robotic surgery for gynecologic cancer affect pressure inside the eye. About 40 women will take part. The goal is to see if using only IV anesthesia keeps eye pressure lower than standard anesthesia, whi…

This study is collecting short video and sound recordings of 200 adults with cancer to create a secure database. The goal is to help researchers develop an artificial intelligence tool that can automatically detect and measure pain by analyzing facial expressions and voice. Parti…

This study is not testing a new drug or treatment. Instead, it will collect information from 3000 adults taking oral anticancer drugs at home to understand how well the prescribed doses match what patients actually take, what side effects occur, and how care coordination between …

This study follows 200 adults with solid tumors who are starting immunotherapy (checkpoint inhibitors). Researchers collect blood and tissue samples before and during treatment to understand why some patients develop immune-related side effects. The goal is to find early warning …