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New combo therapy targets hard-to-treat endometrial cancer

NCT ID NCT05997017

Recruiting now Disease control Sponsor: Aadi Bioscience, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of two drugs, nab-sirolimus and letrozole, in 29 people with advanced or recurrent endometrioid endometrial cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or slows cancer growth. Participants take both drugs by mouth and are monitored for response and side effects.

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Conditions

The condition(s) this trial relates to.

cancer endometrial cancer endometrial carcinoma endometrial endometrioid adenocarcinoma endometrioid tumor endometrium neoplasm neoplasm Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER ENDOMETRIAL CANCER ENDOMETRIOID ENDOMETRIAL CANCER ENDOMETRIOID TUMOR RECURRENT ENDOMETRIAL CARCINOMA TUMOR

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Levine Cancer Institute

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Michael Birrer, MD, PhD

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • Mount Sinai Comprehensive Cancer Center

    RECRUITING

    Miami Beach, Florida, 33140, United States

  • Oklahoma University Stephenson Cancer Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Swedish Cancer Institute

    RECRUITING

    Seattle, Washington, 98104, United States

  • Texas Oncology - Tyler

    RECRUITING

    Tyler, Texas, 75702, United States

  • Women & Infants Hospital

    RECRUITING

    Providence, Rhode Island, 02905, United States

    Contact Email: •••••@•••••

  • Women's Cancer Center of Nevada

    RECRUITING

    Las Vegas, Nevada, 89106, United States

More trials for these conditions

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