TUMOR

This study tests an experimental drug called nirogacestat in 40 adults with desmoid tumors (a type of non-cancerous but painful growth). The goal is to see if the drug is safe and how it affects the tumors. Participants receive the drug and are monitored for side effects and tumo…

This early-stage study tests a drug called nab-sirolimus in people with advanced solid tumors who also have moderate liver impairment. The goal is to find a safe dose and see how the body processes the drug. About 28 adults will take part, and the study is currently recruiting.

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 104 participants will receive the combination treatment. The goal is to see if the drugs…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This study tests whether people with a rare form of muscle-invasive bladder cancer can keep their bladder by first receiving chemotherapy (with or without immunotherapy) and then a combination of radiation and low-dose chemotherapy. The goal is to see if this approach is feasible…

This study is testing a new imaging agent called [68Ga]Ga-NI-FAPI-04 for PET/CT scans to see if it can better detect diseases related to fibroblast activation protein, such as tumors, heart disease, lung fibrosis, and immune conditions. About 30 adults aged 18-85, including both …

This study collects images and videos from routine capsule endoscopy procedures to train an artificial intelligence system. The goal is to help doctors detect bowel diseases like Crohn's, celiac disease, and tumors more accurately and quickly. Up to 10,000 participants will contr…

This early-phase study tests a new radioactive tracer called 68Ga-FXX489 (NNS309) for PET/CT scans. The goal is to see if it can safely and accurately detect tumors and cancer that has spread. About 30 adults with suspected cancer will receive the tracer and then be scanned. Rese…

This study tests a new type of PET scan (68Ga-NK224) to see if it can accurately measure PD-L1 levels in tumors without needing a biopsy. About 100 adults with cancer will get the scan, and the results will be compared to standard tissue tests. The goal is to find a less invasive…

This study aims to understand why immune checkpoint inhibitors, a type of cancer treatment, can sometimes cause heart problems. Researchers will analyze blood samples and genetic factors from 1,200 adults starting this therapy. The goal is to find ways to predict and separate hea…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study tests an artificial intelligence tool that helps doctors spot blood vessels during advanced endoscopy procedures. The goal is to reduce the risk of bleeding and injury. About 20 people with swallowing problems or tumors will take part. The AI works in real time to guid…