TUMOR

This early-stage trial tests a new therapy where a patient's own immune cells are genetically modified to recognize and attack cancer cells with a specific KRAS mutation. The study includes 9 adults with advanced solid tumors who have no other treatment options. The goal is to ch…

This early study tests whether combining two drugs, pembrolizumab and lenvatinib, can help control advanced pancreatic cancer that has not responded to prior treatment. About 15 adults with metastatic pancreatic adenocarcinoma will receive the combination. The goal is to see if t…

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than standard chemotherapy (cisplatin) plus radiation for people with advanced head and neck cancer. About 126 participants with p16-positive cancer will be randomly assi…

This early-phase study tests a new treatment called OBX-115, which uses a patient's own tumor-fighting immune cells that have been modified in the lab to include a protein (IL15) to help them survive longer. These cells are given along with acetazolamide to adults with metastatic…

This study tests whether combining two drugs, obinutuzumab and CC-99282, can control follicular lymphoma that has a high tumor burden and has not been treated before. About 33 adults with stage II–IV disease will receive the combination and be monitored for side effects and respo…

This study tests a new device that uses focused sound waves to destroy kidney tumors without making any cuts. About 67 adults with a single small kidney tumor (3 cm or less) will receive this treatment. The goal is to see if the device can safely and effectively eliminate the tum…

This early-phase study tested a new oral drug called AZD6244 in 58 adults with advanced solid tumors that had stopped responding to standard therapies. The main goal was to check the drug's safety and how the body processes it. Researchers monitored side effects, vital signs, and…

This study tests if using focused ultrasound (MR-HIFU) alone or with standard radiation can better relieve bone pain caused by cancer that has spread to the bones. About 216 adults with painful bone metastases will receive either ultrasound, ultrasound plus radiation, or radiatio…

This study tests a new MRI guidance software called Philips Interventional iSuite to see if it helps doctors place needles more quickly and accurately during biopsies and tumor ablations. About 12 people already scheduled for an MRI-guided procedure will take part. The goal is to…

This study follows 1,000 children with cancer who are receiving proton therapy as part of their standard care at St. Jude Children's Research Hospital. The goal is to track serious side effects caused by the radiation. No new treatments are being tested; instead, researchers are …

This study collects blood and urine samples from 1,000 adults who are receiving radiation therapy for cancer. Researchers want to learn how radiation affects genes in white blood cells, damages red blood cells, and changes hormone levels. Samples are taken before, during, and aft…