TUMOR

This early-stage study is testing the safety of a new type of personalized cell therapy called NW-301VT for people with advanced solid tumors that have a specific genetic change (KRAS G12V mutation). About 9 participants will have their own immune cells collected, genetically mod…

This study is testing whether a newer immunotherapy drug (pembrolizumab) combined with radiation works better than the current standard treatment of chemotherapy plus radiation for people with advanced head and neck cancer. It will involve 126 patients whose cancer is linked to t…

This study is testing a device that uses focused sound waves to destroy small kidney tumors without making any cuts. It enrolled 67 adults with single, small kidney tumors to see if the treatment safely eliminates the tumor tissue. Researchers will follow participants for five ye…

This is a small, early-stage study to see if a combination of two drugs, pembrolizumab and lenvatinib, can help control advanced pancreatic cancer that has worsened after initial treatment. The study will enroll about 15 patients to check if the treatment shrinks tumors and is sa…

This is a first-in-human study to test the safety and find the right dose of a new, personalized cell therapy called OBX-115, given with the drug acetazolamide. It is for adults whose metastatic melanoma has come back or stopped responding to standard immunotherapy. Researchers w…

This study is testing whether a non-surgical treatment using focused sound waves (MR-HIFU), either alone or combined with standard radiation therapy, can relieve pain from cancer that has spread to the bones faster and better than radiation alone. It involves about 216 adult pati…

This study aims to understand how radiation therapy for cancer affects the body by collecting blood and urine samples from patients. Researchers will analyze these samples to see changes in genes, cells, and hormones. The goal is to gather knowledge, not to provide a new treatmen…

This is a very early study to check if a new cancer drug called AZD6244, given as a capsule, is safe and how it moves through the body. It involved 58 adults with advanced solid tumors that had not responded to standard treatments. The main goal was to find the right dose and und…

This study is observing 1,000 children who have already received proton therapy for cancer at St. Jude Children's Research Hospital. The goal is to collect long-term safety data over 10 years to understand the risks of serious side effects from this type of radiation. The childre…