TUMOR

This study tests a device that uses focused sound waves (histotripsy) to break apart kidney tumors without making any cuts. About 67 adults with a single small kidney mass (3 cm or less) that hasn't spread will be treated. The goal is to see if the tumors are completely gone afte…

This early-stage study tested the safety of an experimental cancer drug called AZD6244, given as a capsule, in 58 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check for side effects and how the drug moves through the b…

This early-phase trial tests a new treatment for people with advanced melanoma that has stopped responding to standard immunotherapy. The treatment uses a patient's own immune cells (TILs) that have been engineered to produce a protein called IL15, combined with a drug called ace…

This study tests whether combining two drugs, obinutuzumab and CC-99282, can control follicular lymphoma in people with a high tumor burden who have not had prior treatment. About 33 adults with stage II–IV disease will receive the combination and be monitored for side effects an…

This early-phase trial tests a new type of immune cell therapy called NW-301VT for people with advanced solid tumors that have a specific KRAS mutation (G12V) and no standard treatment options. The therapy uses the patient's own T cells, which are genetically engineered to recogn…

This early study tests whether combining two drugs, pembrolizumab (Keytruda) and lenvatinib, can help control advanced pancreatic cancer that has already been treated. Fifteen participants will receive the combination to see if it shrinks tumors. The goal is to gather initial dat…

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than the standard chemotherapy drug cisplatin with radiation for patients with a certain type of head and neck cancer (p16-positive). About 126 adults with advanced or in…

This study tests whether MR-guided focused ultrasound (MR-HIFU), alone or with standard radiotherapy, can better relieve pain from bone metastases than radiotherapy alone. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to …

This study collects blood and urine samples from 1,000 adults receiving radiation therapy for cancer. Researchers want to learn how radiation affects gene activity in white blood cells, damages red blood cells, and changes hormone levels. No new treatment is being tested—this is …

This study is watching 1,000 children with cancer who are getting proton therapy, a type of radiation. The goal is to see how often serious side effects happen. The treatment itself is not part of this study—it's just being observed. This will help doctors understand if proton th…

This study tests new MRI guidance software called Philips Interventional iSuite. Doctors will use it to guide needles for biopsies and tumor ablations in 12 patients already scheduled for these procedures. The goal is to see if the software helps place needles faster and more acc…