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New drug IMA402 targets tough cancers in early trial

NCT ID NCT05958121

Recruiting now Disease control Sponsor: Immatics Biotechnologies GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests a new drug called IMA402 in people with advanced solid tumors that have come back or not responded to treatment. IMA402 is designed to help the immune system attack cancer cells. The trial will check if the drug is safe and whether it can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

IMA402 (a bispecific TCER molecule targeting PRAME)

What this could lead to

If successful, this could lead to a new treatment option for patients with hard-to-treat solid tumors that have not responded to standard therapies.

What could go wrong

This is an early first-in-human trial, so safety and effectiveness are not yet known. The treatment may cause side effects or fail to shrink tumors.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cancer metastatic malignant neoplasm neoplasm Recurrence refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER RECURRENT CANCER REFRACTORY CANCER SOLID TUMOR, ADULT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Antoni von Leeuwenhoek- Netherlands Cancer Institute

    RECRUITING

    Amsterdam, North Holland, 1066 CX, Netherlands

  • Elbe Kliniken Stade- Buxtehude Elbe Klinikum Buxtehude gGmbH

    RECRUITING

    Buxtehude, Lower Saxony, 21614, Germany

  • Goethe University Frankfurt

    RECRUITING

    Frankfurt am Main, Hesse, 60590, Germany

  • Johannes Wesling Klinikum Minden

    RECRUITING

    Minden, North Rhine-Westphalia, 32429, Germany

  • Justus-Liebig-Universitaet Giessen

    RECRUITING

    Giessen, Hesse, 35392, Germany

  • KEM I Evang. Kliniken Essen-Mitte gGmbH

    RECRUITING

    Essen, North Rhine-Westphalia, 45136, Germany

  • Klinikum Chemnitz gGmbH

    RECRUITING

    Chemnitz, Saxony, 09116, Germany

  • Klinikum Nürnberg

    RECRUITING

    Nuremberg, Bavaria, 90419, Germany

  • Leiden Universitair Medisch Centrum

    RECRUITING

    Leiden, South Holland, 2333 ZA, Netherlands

  • Marien Hospital Duesseldorf GmbH

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40479, Germany

  • Philipps-Universitaet Marburg

    RECRUITING

    Marburg, Hesse, 35043, Germany

  • Sana Klinikum Offenbach GmbH

    NOT_YET_RECRUITING

    Offenbach, Hesse, 63069, Germany

  • Thoraxklinik Heidelberg gGmbH

    NOT_YET_RECRUITING

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Universitaet Muenster

    NOT_YET_RECRUITING

    Münster, North Rhine-Westphalia, 48149, Germany

  • Universitaetsklinikum Bonn AöR

    RECRUITING

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR

    RECRUITING

    Dresden, Saxony, 01307, Germany

  • Universitaetsklinikum Erlangen AöR

    RECRUITING

    Erlangen, Bavaria, 91054, Germany

  • Universitaetsklinikum Essen AöR

    RECRUITING

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitaetsklinikum Heidelberg AöR

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitaetsklinikum Magdeburg AöR

    RECRUITING

    Magdeburg, Saxony-Anhalt, 39120, Germany

  • Universitaetsklinikum Mannheim GmbH

    RECRUITING

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Universitaetsklinikum Regensburg

    RECRUITING

    Regensburg, Bavaria, 93053, Germany

  • Universitaetsklinikum Tuebingen AöR

    NOT_YET_RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • Universitaetsklinikum Ulm AöR

    RECRUITING

    Ulm, Baden-Wurttemberg, 89081, Germany

  • Universitaetsklinikum Wuerzburg AöR

    RECRUITING

    Würzburg, Bavaria, 97080, Germany

  • Universitaetsmedizin Goettingen

    NOT_YET_RECRUITING

    Göttingen, Lower Saxony, 37075, Germany

  • Universitair Medisch Centrum Groningen

    RECRUITING

    Groningen, 9713 GZ, Netherlands

  • Universitair Medisch Centrum Utrecht

    RECRUITING

    Utrecht, 3584 CX, Netherlands

  • University Of Leipzig

    RECRUITING

    Leipzig, Saxony, 04103, Germany