Could routine brain scans catch hidden cancer spread?

NCT ID NCT07748598

Recruiting now Diagnosis Sponsor: The Clatterbridge Cancer Centre NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial explores whether it is practical to offer routine brain MRI scans to people with HER2-positive metastatic breast cancer. Participants receive a baseline scan and are then randomly assigned to either two more scans over a year or no further scans. The goal is to see if enough people are willing to join such a study, which could pave the way for a larger trial to determine if surveillance improves outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Brain MRI surveillance
What this could lead to: If feasible, this could lead to a larger study that determines whether routine brain scans improve outcomes for people with HER2-positive metastatic breast cancer.
What could go wrong: This is a small feasibility study, not a large trial, so it may not provide definitive answers. It also involves extra scans, which could cause anxiety or lead to unnecessary procedures.

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Conditions

The condition(s) this trial relates to.

cancer HER2 positive breast carcinoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER CNS HER 2 POSITIVE BREAST CANCER

Contacts and locations

Locations

The Clatterbridge Cancer Centre NHS Foundation Trust
RECRUITING

Liverpool, United Kingdom

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