New combo therapy takes on bulky tumors
NCT ID NCT06936748
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a new approach for people with large, relapsed solid tumors that have not responded to standard treatments. It combines a special type of radiation (spatially fractionated radiation therapy) with two immunotherapy drugs (iparomlimab and tuvonralimab). The goal is to see if this combination is safe and can shrink tumors or control the disease. The study will enroll 30 participants and will also look for biomarkers that might predict who benefits most.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Iparomlimab and tuvonralimab (immunotherapy drugs) plus spatially fractionated radiation therapy
- What this could lead to
- If it works, this could offer a new treatment option for people with large, treatment-resistant tumors, potentially shrinking them and slowing disease progression.
- What could go wrong
- This is an early phase 2 trial with only 30 participants, so results may not apply to everyone. The combination of radiation and immunotherapy can cause significant side effects, and it's not yet known if it will be more effective than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Second Affiliated Hospital of Nanchang University
RECRUITINGNanchang, Jiangxi, 330006, China
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Other studies related to the condition(s) this trial covers.
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