Second Affiliated Hospital Of Nanchang University

This study tests whether a special radiation method (SFRT) given alongside immunotherapy (tislelizumab) and standard chemotherapy can shrink stage III lung tumors that cannot be surgically removed. The goal is to see if this combination makes more patients eligible for surgery. T…

This trial investigates whether combining two targeted drugs, vebreltinib and furmonertinib, can control advanced non-small cell lung cancer in people whose tumors have both an EGFR mutation and high PD-L1 expression. The study enrolls about 45 adults who have not received prior …

This study tests whether starting lumbar drainage and injecting the clot-busting drug urokinase early after a severe brain bleed improves patients' recovery. About 424 adults with a first-time severe aneurysmal subarachnoid hemorrhage will be randomly assigned to get either the a…

This phase 2 trial is testing whether adding the antidepressant olanzapine to standard immunotherapy (nivolumab) helps people with advanced EGFR-negative non-small cell lung cancer live longer. About 156 participants will receive either the combination or immunotherapy alone for …

This phase 2 trial is testing a new approach for people with large, relapsed solid tumors that have not responded to standard treatments. It combines a special type of radiation (spatially fractionated radiation therapy) with two immunotherapy drugs (iparomlimab and tuvonralimab)…

This study tests a higher dose of a targeted therapy (EGFR-TKI) combined with two other drugs for people with advanced lung cancer that has spread to the lining of the brain and worsened on standard treatment. About 30 participants will receive the triple combination to see if it…

This study compares weekly semaglutide injections to a calorie-restricted diet in 100 adults with type 2 diabetes and fatty liver disease. Over 12 weeks, researchers will measure changes in blood sugar, weight, inflammation, and liver fat. The goal is to see which approach works …

This study tests whether transplanting healthy bacteria from the eye's surface can help people with moderate to severe dry eye. Forty participants will either receive the bacteria transplant or a fake procedure. Researchers will measure changes in eye discomfort and surface damag…

This study tests whether a probiotic called MR-61 can help slow the worsening of nearsightedness (myopia) in children and teens aged 3 to 18. Participants will take either the probiotic or a placebo daily for a period, and researchers will measure changes in their vision and eye …

This study tests whether a procedure called superselective adrenal artery embolization can improve blood vessel function in people with primary aldosteronism, a condition where the adrenal glands make too much of the hormone aldosterone, causing high blood pressure. The procedure…

This study tests an artificial intelligence (AI) algorithm that analyzes videos from SMILE eye surgery to predict complications like cloudy bubbles or suction loss during the procedure, as well as outcomes like vision correction and corneal thickness afterward. Researchers will e…

This study tests whether a computer program (a deep neural network) can accurately predict the best lens size and position for people having surgery to correct nearsightedness. About 326 adults aged 18-45 will have their eyes scanned before surgery, and the AI's predictions will …

This study tests a specially designed nursing program for people recovering from varicose vein surgery. The program focuses on teaching patients how to manage their own recovery, including daily activities and medical care. Researchers will measure whether this approach improves …

This study compares a new guidewire (AccuSafe) to the standard needle used to cross the heart wall during catheter ablation for atrial fibrillation. The goal is to see if the guidewire is safer and more effective, especially when done without X-ray guidance. 80 patients will be r…

This study tests whether adding a long-acting painkiller (liposomal bupivacaine) to a standard steroid injection during shoulder surgery can improve recovery for people with rotator cuff tears and shoulder stiffness. About 70 adults will be randomly assigned to receive either the…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study looks at whether a measure called Phenotypic Age Acceleration (PhenoAgeAccel), calculated from routine blood tests, can predict who will develop major chronic diseases like diabetes, dementia, cancer, or lung disease, and how long they might live. Researchers will foll…

This study aims to create an artificial intelligence (AI) model to help doctors diagnose and predict recovery for people with a bleeding stroke (spontaneous intracerebral hemorrhage). The researchers will use brain scans and other data from 7,100 patients to train the AI. The goa…

This study is tracking 5,000 people who had a brain bleed from a ruptured aneurysm. Researchers are collecting medical data to find factors that predict complications like delayed brain injury or long-term disability. The goal is to create a computer model that helps doctors fore…

This study looks at why some people develop higher-order vision distortions after SMILE laser eye surgery when a tiny piece of the removed lens is left in the eye. Researchers will measure changes in the eye's surface shape before and after surgery in 33 people. The goal is to un…