Could a lung cancer drug treat rare tumors? new trial aims to find out
NCT ID NCT05770544
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tests the drug entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called ROS1 fusion. The drug is already approved for some lung cancers, but researchers want to see if it works for other tumor types. About 30 adults, teens, and children will take the drug daily until their cancer worsens or side effects become too severe. The main goals are to see if tumors shrink or stop growing for at least 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Entrectinib (Rozlytrek)
What this could lead to
If successful, this could expand the use of entrectinib to treat many rare cancers with a ROS1 gene fusion, offering a new option for patients with limited treatments.
What could go wrong
This is an early-phase trial with only 30 participants, so results may not apply to everyone. The drug may cause side effects or not work for all cancer types.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Addenbrooke's Hospital
RECRUITINGCambridge, CB2 OQQ, United Kingdom
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Alder Hey Hospital
RECRUITINGLiverpool, L14 5AB, United Kingdom
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Belfast City Hospital
RECRUITINGBelfast, BT9 7AB, United Kingdom
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Birmingham Children's Hospital
NOT_YET_RECRUITINGBirmingham, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bristol Haematology and Oncology Centre
RECRUITINGBristol, BS2 8ED, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bristol Royal Hospital for Children
RECRUITINGBristol, BS2 8BJ, United Kingdom
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Cardiff Children's Hospital
NOT_YET_RECRUITINGCardiff, CF14 4XW, United Kingdom
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Churchill Hospital
RECRUITINGOxford, OX3 7LE, United Kingdom
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Clatterbridge Cancer Centre
RECRUITINGMetropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Freeman Hospital
RECRUITINGNewcastle, NE7 7DN, United Kingdom
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Great North Children's Hospital
RECRUITINGNewcastle, NE1 4LP, United Kingdom
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Great Ormond Street Hospital
RECRUITINGLondon, WC1N 3JH, United Kingdom
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Guy's Hospital
RECRUITINGLondon, SE1 9RT, United Kingdom
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John Radcliffe Hospital
RECRUITINGOxford, OX3 9DU, United Kingdom
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Leicester Royal Infirmary
RECRUITINGLeicester, LE1 5WW, United Kingdom
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Royal Hospital for Children Glasgow
RECRUITINGGlasgow, G51 4TF, United Kingdom
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Royal Manchester Children's Hospital
NOT_YET_RECRUITINGManchester, M13 9WL, United Kingdom
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Sheffield's Children's Hospital
RECRUITINGSheffield, S10 2TH, United Kingdom
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Southampton General Hospital
RECRUITINGSouthampton, SO16 6YD, United Kingdom
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The Beatson Hospital
RECRUITINGGlasgow, G12 OYN, United Kingdom
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The Christie Hospital
RECRUITINGManchester, M20 4BX, United Kingdom
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The Royal Marsden Hospital
RECRUITINGSutton, SM2 5PT, United Kingdom
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University College London Hospital
RECRUITINGLondon, NW1 2BU, United Kingdom
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University Hospital Birmingham
RECRUITINGBirmingham, B15 2TT, United Kingdom
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Velindre Cancer Centre
RECRUITINGCardiff, CF14 2TL, United Kingdom
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Western General Hospital
RECRUITINGEdinburgh, EH4 2XU, United Kingdom
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Weston Park Hospital
RECRUITINGSheffield, S10 2SJ, United Kingdom
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