Could a lung cancer drug treat rare tumors? new trial aims to find out

NCT ID NCT05770544

Recruiting now Disease control Sponsor: Cancer Research UK Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests the drug entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called ROS1 fusion. The drug is already approved for some lung cancers, but researchers want to see if it works for other tumor types. About 30 adults, teens, and children will take the drug daily until their cancer worsens or side effects become too severe. The main goals are to see if tumors shrink or stop growing for at least 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Entrectinib (Rozlytrek)
What this could lead to: If successful, this could expand the use of entrectinib to treat many rare cancers with a ROS1 gene fusion, offering a new option for patients with limited treatments.
What could go wrong: This is an early-phase trial with only 30 participants, so results may not apply to everyone. The drug may cause side effects or not work for all cancer types.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm cancer glioma hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm lymphoproliferative syndrome melanoma neoplasm Neoplasms by Histologic Type Neoplasms by Site

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN NEOPLASMS CANCER GLIOMA HAEMATOLOGICAL MALIGNANCY LYMPHOPROLIFERATIVE DISORDERS MALIGNANCY MALIGNANT NEOPLASM MELANOMA NEOPLASMS BY HISTOLOGIC TYPE NEOPLASMS BY SITE SOLID TUMOUR

Contacts and locations

Locations

Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 OQQ, United Kingdom
Alder Hey Hospital
RECRUITING

Liverpool, L14 5AB, United Kingdom
Belfast City Hospital
RECRUITING

Belfast, BT9 7AB, United Kingdom
Birmingham Children's Hospital
NOT_YET_RECRUITING

Birmingham, United Kingdom
Bristol Haematology and Oncology Centre
RECRUITING

Bristol, BS2 8ED, United Kingdom
Bristol Royal Hospital for Children
RECRUITING

Bristol, BS2 8BJ, United Kingdom
Cardiff Children's Hospital
NOT_YET_RECRUITING

Cardiff, CF14 4XW, United Kingdom
Churchill Hospital
RECRUITING

Oxford, OX3 7LE, United Kingdom
Clatterbridge Cancer Centre
RECRUITING

Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
Freeman Hospital
RECRUITING

Newcastle, NE7 7DN, United Kingdom
Great North Children's Hospital
RECRUITING

Newcastle, NE1 4LP, United Kingdom
Great Ormond Street Hospital
RECRUITING

London, WC1N 3JH, United Kingdom
Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
John Radcliffe Hospital
RECRUITING

Oxford, OX3 9DU, United Kingdom
Leicester Royal Infirmary
RECRUITING

Leicester, LE1 5WW, United Kingdom
Royal Hospital for Children Glasgow
RECRUITING

Glasgow, G51 4TF, United Kingdom
Royal Manchester Children's Hospital
NOT_YET_RECRUITING

Manchester, M13 9WL, United Kingdom
Sheffield's Children's Hospital
RECRUITING

Sheffield, S10 2TH, United Kingdom
Southampton General Hospital
RECRUITING

Southampton, SO16 6YD, United Kingdom
The Beatson Hospital
RECRUITING

Glasgow, G12 OYN, United Kingdom
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
The Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
University College London Hospital
RECRUITING

London, NW1 2BU, United Kingdom
University Hospital Birmingham
RECRUITING

Birmingham, B15 2TT, United Kingdom
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Western General Hospital
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
Weston Park Hospital
RECRUITING

Sheffield, S10 2SJ, United Kingdom

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