BRAIN NEOPLASMS

This early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …

This study tests whether using advanced brain network mapping (connectome-guided navigation) during surgery can better preserve functions like speech and movement in people with brain tumors in critical areas. Two hundred participants will be randomly assigned to either this new …

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This trial tests the drug entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called ROS1 fusion. The drug is already approved for some lung cancers, but researchers want to see if it works for other tumor types. About 30 adults, teens, and chi…

This study tests a new MRI sequence that aims to make brain tumors (metastases) more visible after a standard contrast injection. Researchers will compare the new method to the usual MRI in 100 adults with known or suspected brain tumors. The goal is to see if the new scan finds …

This study tests whether a 5-minute guided meditation played during each radiation session can help reduce anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after …

This study tests whether a 6-week occupational therapy group programme can improve quality of life and daily functioning in adults with primary brain tumours who are on active treatment. Participants are randomly assigned to either the group programme or usual care (written infor…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy allows doctors to safely collect fluid samples from the brain over time. Researchers want to see if this method works better than repeated spinal taps for tra…

This study looks at whether platelets—small blood cells that help with clotting—are found inside brain and spinal cord tumors. Researchers want to see if the presence of platelets in these tumors is linked to how long patients survive. The study will involve 50 adults who are hav…

This study tests if analyzing waste from surgical suction devices can help detect brain tumor cells during surgery. About 8 adults with suspected high-grade gliomas or other brain tumors will take part. The goal is to see if this method improves tumor removal compared to standard…