BRAIN NEOPLASMS

This study tests two drugs, elacestrant and abemaciclib, in people whose breast cancer has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults with ER-positive, HER2-negative breast cancer will take part. The study is cur…

This study tests a drug called entrectinib, already approved for certain lung and solid tumors, in people with rare cancers that have a specific genetic change called ROS1 fusion. About 30 adults, teens, and children with these rare cancers will receive the drug. Researchers will…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study compares a new MRI sequence to standard imaging for finding brain metastases. About 100 adults with known or suspected brain tumors will receive an extra scan after routine contrast. The goal is to see if the new method detects more or smaller tumors, improving diagnos…

This study tests whether a short, guided meditation played during radiation therapy can help reduce anxiety in people with brain tumors. About 30 adults will either listen to a 5-minute mindfulness recording during each treatment or receive standard care. Researchers will measure…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study tests a 6-week occupational therapy group program for adults with primary brain tumors who are on active treatment. The program covers fatigue management, cognitive strategies, relaxation, and peer support. Researchers want to see if it improves quality of life and dai…

This study looks at platelets (small blood cells) found in brain and spinal cord tumors. Researchers want to see if platelets help tumors grow or spread, and if their presence is linked to patient survival. About 50 adults having tumor surgery will donate a small piece of their t…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy can help doctors safely collect fluid samples from the brain over time. The goal is to find markers in the fluid that could show how the tumor is growing or r…

This study looks at whether analyzing waste from surgical suction devices can help detect brain tumor cells during surgery. Currently, surgeons use a special dye and a fluorescent light to see tumors, but some cells can be missed. The study will include 8 adults having brain tumo…