NEOPLASMS BY SITE

This study tests two drugs, elacestrant and abemaciclib, in people whose breast cancer has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. About 73 adults with ER-positive, HER2-negative breast cancer will take part. The study is cur…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study tests a drug called entrectinib, already approved for certain lung and solid tumors, in people with rare cancers that have a specific genetic change called ROS1 fusion. About 30 adults, teens, and children with these rare cancers will receive the drug. Researchers will…

This study tests alectinib, a drug already approved for some lung cancers, in patients with rare cancers that have an ALK gene change. About 30 adults and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops them from growing. The goal is…

This study tests whether giving two immunotherapy drugs (nivolumab with or without relatlimab) before surgery can eliminate bladder cancer completely, allowing some patients to avoid bladder removal. About 90 adults with stage II-IIIa bladder cancer will receive the drugs and the…

This study tests a new drug called pocenbrodib, either by itself or combined with other treatments, in people with a type of advanced prostate cancer that no longer responds to hormone therapy. The goal is to find the safest dose and see if it helps shrink tumors or lower PSA lev…

This trial tests a drug called atezolizumab, already approved for some cancers, in people with rare cancers that have high numbers of genetic mutations or specific DNA repair problems. About 30 adults and children with these rare tumor types will receive the drug. The main goal i…

This study tests a new medicine, PF-08634404, combined with chemotherapy against the standard treatment (bevacizumab plus chemotherapy) in people with colorectal cancer that has spread. About 800 adults who have not had prior treatment for metastatic disease will be randomly assi…

This early-stage trial tests a specially engineered virus, G207, in children and young adults whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is given to help t…

This study aims to see how well a robotic system works for finding and taking samples from suspicious spots in the lungs. It will observe 3,000 adults who are already scheduled to have this procedure as part of their regular care. The main goal is to measure how often the biopsy …