Scientists dive deep into immune system to unlock HPV vaccine secrets
NCT ID NCT05031078
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how the HPV vaccine (Gardasil-9) triggers a strong and lasting immune response. Researchers will track 17 healthy adults aged 18-45 who receive three doses of the vaccine. By analyzing blood, saliva, lymph nodes, and bone marrow over several years, they aim to understand why some people maintain high antibody levels for a long time. The goal is to learn how to improve future vaccines, not to test the vaccine itself.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HPV vaccine (Gardasil-9)
- What this could lead to
- If successful, this could help scientists understand how to make vaccines that provide longer-lasting protection against HPV and related cancers.
- What could go wrong
- This is a very small study (17 people) focused on understanding immune responses, not on proving the vaccine works. Results may not apply to everyone, and the procedures (lymph node and bone marrow sampling) carry minor risks like discomfort or bruising.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HPV are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Hope Clinic of Emory University
Atlanta, Georgia, 30030, United States
-
Winship Cancer Institute
Atlanta, Georgia, 30322, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could Self-Sampling revolutionize cervical cancer screening?
- Texting parents could be key to curbing HPV-Related cancers
- Pocket-sized HIV test could bring same-day diagnosis to community clinics
- Can anal cancer treatment spare sexual well-being? a study tracks the toll over two years.
- Simple blood test could spot returning throat cancer sooner
- Double probe heat therapy may slash cervical cancer risk in HIV-positive women