Cholesterol drug boosts immunotherapy in head and neck cancer trial

NCT ID NCT06636734

First seen Feb 16, 2026 · Last updated May 13, 2026 · Updated 6 times

Summary

This study tests whether adding the cholesterol-lowering drug lovastatin to the immunotherapy pembrolizumab can shrink tumors in people with head and neck cancer that has returned or spread. About 28 adults whose cancer has a specific marker (PD-L1 CPS≥1) will receive both drugs. The goal is to see if the combination improves response rates and delays cancer growth.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Emory University Hospital Midtown

    RECRUITING

    Atlanta, Georgia, 30308, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Emory University Hospital/Winship Cancer Institute

    RECRUITING

    Atlanta, Georgia, 30322, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.

CLINICAL STAGE IV HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 CLINICAL STAGE IV HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 HUMAN PAPILLOMAVIRUS-RELATED NECK SQUAMOUS CELL CARCINOMA OF UNKNOWN PRIMARY METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA METASTATIC HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC LARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC NASOPHARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC ORAL CAVITY SQUAMOUS CELL CARCINOMA METASTATIC ORAL CAVITY SQUAMOUS CELL CARCINOMA METASTATIC OROPHARYNGEAL SQUAMOUS CELL CARCINOMA METASTATIC PARANASAL SINUS SQUAMOUS CELL CARCINOMA RECURRENT HEAD AND NECK SQUAMOUS CELL CARCINOMA RECURRENT HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT LARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT NASOPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA RECURRENT ORAL CAVITY SQUAMOUS CELL CARCINOMA RECURRENT OROPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT OROPHARYNGEAL SQUAMOUS CELL CARCINOMA RECURRENT PARANASAL SINUS SQUAMOUS CELL CARCINOMA STAGE IV HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV HYPOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV LARYNGEAL CANCER AJCC V8 STAGE IV LARYNGEAL CANCER AJCC V8 STAGE IV LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IV LIP AND ORAL CAVITY CANCER AJCC V8 STAGE IV NASOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV NASOPHARYNGEAL CARCINOMA AJCC V8 STAGE IV OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IV OROPHARYNGEAL (P16-NEGATIVE) CARCINOMA AJCC V8 STAGE IV SINONASAL CANCER AJCC V8 STAGE IV SINONASAL CANCER AJCC V8