New combo therapy aims to keep High-Risk childhood cancers at bay
NCT ID NCT04469530
First seen Mar 01, 2026 · Last updated May 16, 2026 · Updated 6 times
Summary
This study tests whether a year-long maintenance treatment with sirolimus and low-dose chemotherapy can help prevent cancer from coming back in children and young adults (ages 1 to 30) with high-risk solid tumors. Participants take daily sirolimus and twice-daily celecoxib along with low-dose oral chemotherapy after finishing standard treatment. The goal is to improve the number of patients who remain cancer-free for at least two years compared to similar patients who only received standard therapy.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aflac Cancer & Blood Disorders Centers
RECRUITINGAtlanta, Georgia, 30329, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30329, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC)
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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