Immunotherapy after surgery may keep colon cancer from returning

NCT ID NCT07140679

Recruiting now Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether the immunotherapy drug toripalimab can lower the chance of cancer coming back after surgery in people with mismatch repair deficient (dMMR) stage IIB, IIC, or III colon cancer. About 40 participants will receive toripalimab intravenously. The study will track how many remain cancer-free after three years and monitor for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: toripalimab (an immunotherapy drug)
What this could lead to: If successful, this could offer a new way to prevent colon cancer from coming back after surgery for people with a specific genetic feature.
What could go wrong: This is a small, early-phase trial with only 40 people, so results may not apply to everyone. Immunotherapy can cause side effects like inflammation in healthy organs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm malignant colon neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALIZED COLON CARCINOMA STAGE IIB COLON CANCER AJCC V8 STAGE IIC COLON CANCER AJCC V8 STAGE III COLON CANCER AJCC V8

Contacts and locations

Locations

Emory Decatur Hospital
RECRUITING

Atlanta, Georgia, 30033, United States
Emory Johns Creek Hospital
RECRUITING

Johns Creek, Georgia, 30097, United States
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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