New hope for hard-to-treat lung cancer: triple therapy targets resistant tumors
NCT ID NCT06495125
First seen Apr 07, 2026 · Last updated Apr 28, 2026 · Updated 3 times
Summary
This study tests a combination of two targeted drugs (defactinib and avutometinib) plus an immunotherapy (nivolumab) in 50 adults with advanced LKB1-mutant lung adenocarcinoma that no longer responds to standard anti-PD1 treatment. The goal is to see if this triple therapy can shrink tumors or slow cancer growth. Participants must have a specific genetic mutation (LKB1) and have tried prior treatments without success.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Emory Saint Joseph's Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
Contact Email: •••••@•••••
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Emory University Hospital Midtown
NOT_YET_RECRUITINGAtlanta, Georgia, 30308, United States
Contact Email: •••••@•••••
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Conditions
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