Can a chest X-Ray and blood test quickly rule out TB?
NCT ID NCT04666311
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to standard lab methods to see if they could accurately rule out TB. The goal is to find a fast, affordable way to screen for TB in busy clinics.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CAD4TB software and Afinion CRP blood test
What this could lead to
If successful, these tests could provide a quick, low-cost way to rule out TB in clinics, reducing the need for more complex lab tests.
What could go wrong
This is a completed accuracy study, not a treatment trial. The tests may not be sensitive enough in all settings, and results may not apply to everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Butha-Buthe District Hospital
Butha-Buthe, Lesotho
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Caluza Clinic
Pietermaritzburg, KwaZulu-Natal, South Africa