Can a chest X-Ray and blood test quickly rule out TB?

NCT ID NCT04666311

Completed Diagnosis Sponsor: Klaus Reither Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to standard lab methods to see if they could accurately rule out TB. The goal is to find a fast, affordable way to screen for TB in busy clinics.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CAD4TB software and Afinion CRP blood test
What this could lead to: If successful, these tests could provide a quick, low-cost way to rule out TB in clinics, reducing the need for more complex lab tests.
What could go wrong: This is a completed accuracy study, not a treatment trial. The tests may not be sensitive enough in all settings, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alagille syndrome COVID-19 HIV infectious disease pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19 HIV PULMONARY TUBERCULOSIS TUBERCULOSIS DIAGNOSIS

Contacts and locations

Locations

Butha-Buthe District Hospital

Butha-Buthe, Lesotho
Caluza Clinic

Pietermaritzburg, KwaZulu-Natal, South Africa

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