HIV

This early-phase trial tests a new HIV vaccine strategy in 36 healthy adults without HIV. The vaccine uses ferritin nanoparticles to display HIV envelope proteins, followed by an mRNA boost. The goal is to safely trigger broadly neutralizing antibodies that could protect against …

This study tests whether extra COVID-19 vaccine doses are safe and work well for people with weakened immune systems, such as those with HIV, organ transplants, or blood cancers. Around 960 participants will receive different booster schedules to see which one boosts their protec…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This study tests if gabapentin, a medication for nerve pain, can help people with HIV who drink heavily achieve undetectable viral loads. About 220 participants will receive either gabapentin or a placebo for 3 months, along with counseling. The goal is to see if the drug improve…

This study looks at the safety and effectiveness of the HIV medication B/F/TAF in pregnant women who have had their virus under control for at least six months. About 50 women in their first trimester will continue taking the drug through pregnancy and 12 weeks after birth. Resea…

This study tests a 4-session behavioral program to reduce alcohol use in 450 people with TB and HIV in India. Unhealthy drinking can worsen TB and HIV outcomes. The program is added to usual care, and researchers will check if it lowers alcohol use and improves health. The goal i…

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study tests a program called Healthy Choices, which uses text messages and telehealth sessions to help young people with HIV (ages 18-29) in Florida manage their alcohol use and take their HIV medication every day. The goal is to improve daily medication adherence and viral …

This study looks at a rare disease called KSHV-associated multicentric Castleman's disease (MCD), caused by a virus. Researchers are testing several drug combinations, including chemotherapy and antivirals, to see if they can control the disease. The study also tracks how the dis…

This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 week…

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This study tests a mobile app called HealthMPowerment (HMP) designed to help young gay and bisexual men (ages 15-24) either start HIV prevention (PrEP) or stay on HIV treatment. About 1500 participants will get the app right away or after a delay. Researchers will see if the app …

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This study tests whether offering small prizes (phone credit) can encourage young people aged 15-30 with HIV to take their medication every day. 560 participants in Uganda are split into groups with different reward rules. The goal is to see if these low-cost incentives improve a…

This study is testing two mobile health tools—a computer-delivered program and motivational text messages—to help young adults (ages 18-24) in Zambia better manage their HIV and cut down on alcohol use. The goal is to see if these tools are easy to use and acceptable to participa…

This early-phase study tests whether taking prebiotic fiber and probiotics can improve fatty liver disease in people with HIV. Researchers believe changes in gut bacteria may contribute to liver problems. The trial involves 63 participants and measures liver fat and gut health ma…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This study looks at whether having a nurse case manager helps people with multidrug-resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 patients in South Africa are involved. Half of the clinics have a nurse case manager to guide care, while the oth…

This study tests a 'data-to-suppression' approach to help people with HIV who are not virally suppressed. It uses reports to guide support services for about 1,500 low-income individuals in New York City. The goal is to improve viral suppression rates and reduce health disparitie…

Severe acute malnutrition affects millions of children worldwide and often leads to death after hospital discharge. This phase 3 trial tests whether giving a combination of antibiotics (rifampicin, azithromycin, isoniazid, and vitamin B6) for several weeks can lower the risk of d…

This study tests whether virtual or in-person support helps teens with HIV stay in care and keep the virus under control. About 570 teens aged 15-19 in South Africa will receive either standard care or extra support to prepare for moving to adult clinics. The goal is to see which…

This study looks at whether giving long-acting HIV injections at home is as practical and acceptable as giving them in the hospital. About 120 adults with well-controlled HIV will receive the shots either at home or in the hospital. Researchers will measure how easy and appropria…

This study tests whether baricitinib, a drug used for arthritis, can safely reduce the hidden HIV reservoirs in people who already have the virus under control with standard HIV medication. Thirty adults with HIV will take either baricitinib or a placebo daily for 12 weeks while …

This study looks at whether testing high-risk newborns for HIV right after birth using a point-of-care test can speed up diagnosis and treatment. Infants who test positive will start on a dolutegravir-based drug regimen. Researchers will track how quickly the virus becomes undete…

This phase 2 trial tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) works better than the standard 26-week treatment for drug-susceptible tuberculosis. About 94 adults with TB will be randomly assigned to either the short r…

This study looks at whether giving HIV treatment to babies within the first week of life can reduce the amount of virus hiding in their bodies. Researchers want to see if this early start helps the immune system fight HIV better, possibly allowing children to stop medication for …

This study tests whether text messages and counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,310 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This study tests a pharmacist-led program to help women with HIV who also face social challenges like housing or food insecurity. The program supports switching from daily pills to a long-acting injectable medication (cabotegravir/rilpivirine) given every two months. The goal is …

This study tests whether doxycycline, an antibiotic, can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibiotic r…

This study tests whether a drug called N-803 (IL-15) can train the immune system to control HIV without daily antiretroviral therapy. Twenty people with HIV on stable treatment will receive the drug or a placebo, then temporarily stop their HIV meds to see if the virus stays unde…

This study tests whether combining urban gardening with peer nutritional counseling can improve HIV care outcomes for people who also face food insecurity. About 433 adults with HIV in the Dominican Republic who have trouble getting enough food will take part. The goal is to see …

This study tested whether giving HIV-positive teens in Uganda access to savings accounts, financial training, and mentorship helps them take their HIV medication regularly. 702 teens aged 10-16 from 40 clinics took part. The goal was to see if economic stability can improve treat…

This study tests four different support tools—financial literacy training, matched savings accounts, a cartoon-based adherence guide, and role models with HIV—to see which combination best helps youth aged 11-17 in Uganda stay on their HIV medication and keep the virus undetectab…

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This study tests whether giving higher doses of a TB drug (rifampicin) plus an extra antibiotic (levofloxacin) for 14 days, with or without steroids, can help more people survive. It includes 732 adults with HIV who are hospitalized for TB that has spread beyond the lungs. The go…

This study tests whether a once-weekly combination of two drugs (rifapentine and isoniazid) can safely prevent tuberculosis in children and teens with HIV who are already taking the antiretroviral dolutegravir. About 92 participants aged 3 months to 17 years will receive the TB p…

This study tests whether a simpler two-drug pill (dolutegravir/lamivudine) works as well as a standard three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults with HIV who have never been treated. About 473 participants will take one of the two pills daily fo…

This study tests whether giving HIV patients their own genetically modified stem cells is safe and feasible. The cells are changed to resist HIV, and patients receive a mild chemotherapy drug before infusion. The goal is to see if the modified cells can help control the virus, bu…

This early-stage study tests a new approach to HIV treatment. Researchers take a person's own T-cells, modify them to better recognize and attack HIV, and infuse them back. The main goal is to check safety in 12 stable HIV patients, while also seeing if the modified cells can hel…

This study tests two counseling programs to help women who use drugs in Tanzania start and stay on PrEP, an HIV prevention pill. 200 women will be randomly assigned to receive either brief motivational counseling, the same plus extra mental health support, or standard information…

This study tests whether trained peer navigators, connecting with students through a mobile health app, can increase the use of HIV prevention pills (PrEP) and contraception among sexually active female university students aged 18-24 in Zambia. 324 participants will be randomly a…

This study tests whether nurse-navigators can help adolescent girls and young women in Kenya start and continue taking PrEP, a daily medication that prevents HIV. About 1,900 participants will get PrEP at local pharmacies after buying birth control, and half will also receive ext…

This study works with primary care and reproductive health clinics to make it easier for women who inject drugs to get PrEP, a daily pill that prevents HIV. Researchers are testing a program where clinic staff get extra training and support to identify and prescribe PrEP to these…

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study tests whether giving a long-acting HIV prevention shot (lenacapavir) in community pharmacies is practical and acceptable. Seventy-five HIV-negative adults will receive the injection either twice a year or every three months, and researchers will track how many stay on …

This study compares two low-burden strategies to increase HIV PrEP use among emergency department patients seeking care for sexual health issues. One strategy involves follow-up outreach after the visit, while the other offers a tele-sexual health visit during the ER stay. The go…

This study tests whether sending HIV self-test kits to men who have sex with men on a subscription basis encourages them to test more regularly. 240 participants in Hong Kong will receive reminders to test during a control period, then receive actual test kits during an intervent…

This study tests a 45-60 minute online program called PATHS that teaches parents how to talk to their gay or bisexual sons about sexual health. About 393 parent-teen pairs join, with teens aged 14-19. The goal is to see if the program improves teens' condom use, PrEP awareness, a…

This study is testing a package of tools—training for healthcare workers, quality improvement methods, and a community of practice—to help clinics in Kenya offer HIV prevention pills (PrEP) to pregnant and postpartum women. The goal is to screen more women and start them on PrEP …

This study compares two ways to provide HIV prevention pills (PrEP) to young people in South Africa: the usual clinic-based approach versus a community-based model where pills are delivered and monitored outside clinics. Researchers will enroll 2,500 participants aged 16-30 to se…

This study tests whether a single dose of the HPV vaccine (Gardasil 9) can prevent persistent HPV infection in women living with HIV who have already been vaccinated. About 778 women will receive either the HPV vaccine or a meningitis vaccine (placebo) and be monitored for safety…

This study follows 100 cisgender women in the southern U.S. who are already prescribed long-acting cabotegravir injections (Apretude) for HIV prevention. Over two years, researchers will track how many women stick with the shots, how satisfied they are, and rates of other sexuall…

This study tests a program to help pregnant and breastfeeding women in South Africa take a daily pill called PrEP that prevents HIV. The program includes extra counseling and community delivery of the pills for those who struggle to take them regularly. The goal is to see if this…

This study tests whether a smartphone game called Tumaini can help prevent HIV among 1000 adolescents aged 12-14 in Kenya. The game teaches sexual health, risk reduction, and condom use through role-playing. Researchers will compare outcomes like age at first sex and condom use b…

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study tests whether a home-based physical activity program, using a Fitbit and coaching sessions, can help people with HIV who drink heavily increase their daily steps and reduce their alcohol intake. The trial involves 222 participants in the U.S. who are low-active and dri…

This study tests whether offering chances to win prizes for completing job-search activities helps unemployed people with HIV/AIDS find work. 144 participants will be randomly assigned to either standard employment services or the same services plus prize-based rewards for 16 wee…

This study looks at HIV-infected adults who have been on antiretroviral therapy for a long time and have very low virus levels. Researchers want to see if the virus stays stable or changes over time. Participants visit the clinic every six months for blood tests and a special whi…

This study looks at whether a rapid HIV antibody test can detect when the virus rebounds in people taking antiretroviral therapy (ART). Researchers will analyze stored blood samples from 6100 HIV-positive individuals in the US and sub-Saharan Africa. They will compare antibody le…

This study looks at HIV patients over 40 (or those on HIV therapy for over 10 years) who switched to either a three-drug or a two-drug antiretroviral regimen. Researchers will measure markers of inflammation in the blood and track how many patients develop other health conditions…

This study tests a new digital tool called INCLUDE, designed to help clinics in Nepal identify and reduce stigma faced by people living with HIV. The tool includes a stigma assessment, a dashboard linking stigma to care data, and a library of stigma-reduction activities. Research…

This study checks if some people with HIV might be cured. Ten patients who have had undetectable HIV for at least 6 months will stop their antiretroviral therapy under close medical supervision. Doctors will watch for the virus to come back. The goal is to see if the infection is…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study looks at whether a combination of two anti-HIV antibodies can keep the virus under control after people stop their daily HIV medications. Researchers will compare people who received the antibodies in a previous study to those who got a placebo. Participants will pause…

This study tracks 2,500 people with HIV in Brazil who are taking a common first-line treatment (tenofovir/lamivudine and dolutegravir) to see why some develop drug resistance. Researchers will test blood samples from those whose viral load remains detectable to look for resistanc…

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study looks at how well the HPV vaccine works in women living with HIV and whether self-collected HPV tests can improve cervical cancer screening. About 650 women will use a self-swab kit at home or in the clinic. Those with positive results will get follow-up exams. The goa…

This study looks at 40 people with HIV to see if a common drug, tenofovir, causes more immune system activation and helps the virus hide better in the body. Participants are already on stable HIV treatment and will provide blood and gut samples. The goal is to find ways to reduce…

This study was designed to test a new system that uses tiny silica particles on HIV medication (Biktarvy) and a smartphone app to help people track whether they have taken their pills. The goal was to see if the system is easy to use and accurate over 90 days. However, the study …

This study tests whether a WhatsApp chatbot can improve HIV knowledge in 314 adults recently diagnosed with HIV in Nigeria. Participants use the chatbot for information, reminders, and questions, while a control group receives standard care. The study also looks at effects on res…

This study looks at how well a long-acting HIV injection (CAB+RPV LA) works for people who live far from their doctor. About 55 patients and clinic staff will share their experiences through surveys and interviews over 15 months. The goal is to understand what helps or hinders ge…

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This study tests a new program to make it easier for people living with HIV to get screened for substance use disorders. The program uses online patient portals and in-clinic tools to find those who need help and connect them to treatment. Researchers will track how many people g…

This study tests a program to help caregivers tell children (ages 7-18) their HIV status in a supportive way. It involves 747 children and their caregivers across 12 clinics in Ghana. The goal is to see if this approach improves medication adherence and overall health.

This study looks at how HIV might disrupt the body's internal clock, which could lead to health problems like diabetes and heart disease. Researchers will track gene activity at different times of day in 80 people with and without HIV. The goal is to understand why these issues a…

This small, early study is testing whether spironolactone, a drug already approved for high blood pressure, can reduce the hidden HIV reservoir in people on effective HIV treatment. Researchers will give the drug to 12 adults (both with and without HIV) to see how it affects a ke…

This study follows 127 people with HIV-related Kaposi sarcoma in Malawi and South Africa who are receiving standard chemotherapy (paclitaxel or bleomycin plus vincristine). Researchers want to understand why some patients respond better than others, looking at factors like gender…

This study observes over 15,000 HIV patients in Malawi to see how different ways of delivering HIV treatment (like group visits or community pick-up points) affect viral suppression, patient satisfaction, and clinic efficiency. Researchers surveyed patients and providers at 12 he…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to understand the true scale of this liver condition in this group, which has been largely over…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers will use a non-invasive scan to measure liver stiffness and fat content over one year. The goal is to fill major knowledge gaps, since p…

This study surveys 771 adults with HIV in Zambia who have started or restarted antiretroviral therapy (ART) within the last six months. Researchers want to learn what services and support patients prefer during this critical early period, when many drop out of care. The goal is t…

This study looks at different ways to deliver HIV treatment in Zambia to see which methods work best for patients and clinics. Researchers will survey over 8,000 patients and healthcare providers at 12 health facilities. The goal is to help policymakers make better decisions abou…

This observational study is tracking over 15,500 people with HIV at 24 healthcare facilities in South Africa. Researchers are comparing different ways of delivering HIV treatment and care to see which models work best for patients and healthcare providers. The study looks at vira…

This study surveys about 1,100 adults in South Africa who have recently started or restarted HIV treatment. The goal is to understand what services and support they need to stay in care during the first six months, a time when many patients drop out. Results will help design bett…

This study tests a program called Potlako+ that combines community education, support for healthcare providers, and patient navigation to help people with cancer symptoms get diagnosed and treated faster. About 874 participants in Botswana will be split into two groups: one recei…

This pilot study is testing a new tool called PATH that helps doctors assess the unique health needs of people aged 50 and older living with HIV. Participants will answer questions about their health through a patient portal or with a research coordinator before a routine HIV app…

This study looks at two different methods to help VA clinics adopt a team-based depression care service for veterans living with HIV. The service has been shown to work well and save money, but no VA clinics currently use it. Researchers will compare the two approaches to see whi…

This pilot study looks at whether a computer-based alcohol intervention, combined with help from a community health worker, can reduce heavy drinking and improve HIV prevention among women. About 12 women who drink heavily and are either living with HIV or at risk for it will tak…

This study looks at whether giving staff bonuses for hitting targets helps them deliver better substance use counseling to people with HIV. Researchers are comparing two strategies: one with just training and feedback, and another that adds monetary incentives. The goal is to see…

This study looks at how cannabis (specifically the drug Dronabinol) changes the immune system and genes in people with HIV. Researchers will take blood samples before and after giving Dronabinol to 160 participants. The goal is to understand these changes better, which could help…

This study looks at how well the mpox vaccine works and how safe it is in people with HIV compared to those without HIV. About 174 adults who either recently got the mpox vaccine or had a recent mpox infection will take part. The goal is to fill important knowledge gaps and help …

This study looks at how cannabis (marijuana) affects the levels of HIV medications in the blood and brain, as well as mood and thinking. Researchers will give cannabis or a placebo to 40 people with HIV to see if it changes how their drugs work. The goal is to understand if canna…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study planned to test whether changing the layout and systems of HIV clinics in Uganda could make them feel more private and welcoming, reducing stigma and improving patient retention. Researchers intended to survey patients and staff before and after renovations. However, t…

This study follows 830 women in Alabama who are at risk for HIV and sexually transmitted infections (STIs). Researchers will use a smartphone app to provide information and resources, and track how many women start using PrEP, a medication that prevents HIV. The goal is to learn …