HIV

This early-stage study tests a new HIV vaccine in 36 healthy adults without HIV. The vaccine uses a two-step approach: first, a nanoparticle that displays HIV-like proteins, followed by an mRNA boost to strengthen the immune response. The goal is to see if this combination is saf…

This study tests different COVID-19 booster vaccines in 960 immunocompromised people, including those with HIV, organ transplants, or blood cancers. The goal is to find which booster schedule gives the strongest and safest immune response. Results will help doctors protect these …

This study tests whether the common antibiotic doxycycline can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers with HIV will take doxycycline for 72 weeks. Researchers will measure lung function, walking ability, and check for antibi…

This study looks at whether helping HIV-positive teenagers save money and start small businesses can improve their ability to take their HIV medication every day. The study involves 702 teens aged 10-16 in Uganda. The idea is that financial stability may give them more hope and m…

This study tests whether adding special sugars found in breast milk (called human milk oligosaccharides) to the diet of HIV-exposed but uninfected infants can reduce infections and improve growth. About 140 babies will receive either the supplement or a placebo from 4 to 24 weeks…

This study checks if testing high-risk babies for HIV right after birth and starting them on a modern antiretroviral drug (dolutegravir) can quickly control the virus. About 900 infants in Botswana will be tested at the hospital, and those with HIV will receive treatment and be f…

This study tests whether a 12-week home-based physical activity program can help people living with HIV who drink unhealthy amounts of alcohol. Participants wear a Fitbit to track steps and either get coaching to add more activity to their daily routine or just use the Fitbit alo…

This early-stage study tests whether a patient's own blood stem cells, modified to resist HIV, can be safely infused after a mild chemotherapy-like conditioning. The goal is to see if the modified cells can take hold and help control the virus without lifelong daily medication. T…

This study tests a pharmacist-led program to help women with HIV who also face challenges like housing or food insecurity. The program supports switching from daily pills to a long-acting injectable treatment given every two months. The goal is to see if this approach is practica…

This study looked at three treatments for people with early HIV infection: zidovudine (AZT) alone, interferon alone, or both together. The goal was to see which worked best to lower the amount of virus in the blood, protect the immune system, and delay the first serious infection…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people living with HIV reduce unhealthy alcohol use. About 308 participants in Alabama will receive either the combined program or brief counseling alone. The…

This study tests four different types of support—financial training, savings accounts, a cartoon-based adherence program, and mentorship from HIV-experienced role models—to see which combination best helps youth (ages 11-17) with HIV keep the virus under control. About 576 partic…

This study tests whether giving an antimicrobial (infection-fighting) treatment after hospital discharge can prevent death, re-hospitalization, or poor recovery in children aged 6-59 months with complicated severe acute malnutrition. About 674 children will be randomly assigned t…

This study tests whether offering chances to win prizes can help young people (ages 15-30) with HIV take their medication more regularly. 560 participants in Uganda will be split into groups that receive different types of goals and prize incentives, plus motivational texts. The …

This study looks at a rare, often fatal disease called KSHV-associated multicentric Castleman's disease (MCD), caused by a virus. Researchers want to understand how the disease works and test several experimental treatments, including high-dose zidovudine, valganciclovir, bortezo…

This study tests whether a drug called N-803 (IL-15) can boost the immune system to control HIV without daily antiretroviral therapy. About 20 adults with well-controlled HIV will receive the drug or a placebo, then temporarily stop their regular HIV meds to see if the virus stay…

This study tests whether giving higher doses of the TB drug rifampicin plus an additional antibiotic (levofloxacin) for 14 days, with or without steroids, can save more lives in adults hospitalized with both HIV and disseminated TB (TB that has spread throughout the body). About …

This study looks at whether it is safe for people with HIV to receive a liver transplant from a donor who also had HIV. The main goal is to check for serious problems like organ failure, infections, or HIV complications. About 80 participants are being followed to see how well th…

This study tests two ways to support teenagers living with HIV in South Africa as they move from child to adult clinics. About 570 teens aged 15-19 will get either in-person help or support through a phone app. The goal is to see which method works better at keeping them in care …

This study tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) works better than the standard 6-month treatment for drug-susceptible tuberculosis. About 94 adults with active TB in the lungs will be randomly assigned to either…

This early-phase study tests a new approach to treat HIV by taking a person's own T-cells, modifying them to better recognize and attack HIV-infected cells, and giving them back. The main goal is to check safety in 12 clinically stable HIV patients. Researchers will also look for…

This study tests a program that combines urban gardening with peer nutritional counseling for people living with HIV who also face food insecurity. The goal is to see if this approach can improve HIV outcomes like viral load, medication adherence, and clinic attendance. The study…

This study tests whether offering small prizes for completing job-search activities helps people with HIV find work faster. 144 unemployed participants will receive standard job services plus either encouragement alone or encouragement with chances to win prizes for 16 weeks. Res…

This study tests a program called ENHANCE-TTS that trains pharmacists to help people living with HIV quit smoking. About 172 participants from six clinics will take part. The program gives pharmacists tools and support to offer smoking cessation counseling and medications. The go…

This study tests whether a mobile health program that sends text messages and offers reproductive counseling can help women living with HIV make better-informed decisions about contraception and pregnancy. About 3,300 women receiving HIV care in Kenya will take part. The goal is …

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and acceptable. The approach combines the me…

This study looks at whether having a nurse case manager helps people with multi-drug resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 adults in South Africa are involved. Half of the clinics have a nurse case manager, and the other half do not. T…

This study tests whether a combination of two drugs, dasatinib and quercetin (D+Q), can safely improve physical function in people aged 50 and older with HIV who are frail or prefrail. About 80 participants will receive either D+Q or a placebo over 12 weeks, then be monitored for…

This study looks at whether people with HIV can get their long-acting injections at home instead of at the hospital. About 120 adults who are already stable on HIV medication will be randomly assigned to receive injections either at home or in the hospital. The goal is to see whi…

This study tests whether giving HIV medicines to infected babies within the first week of life can limit the amount of virus that hides in the body. Researchers hope this might allow children to take breaks from medication later on. The study involves 67 infants in Botswana and f…

This study looks at whether using existing medications in a new way can help people with HIV who also have alcohol use disorder drink less. About 30 participants will receive the medication along with counseling and check-ins from a pharmacist. The goal is to see if this approach…

This study tests a program to help 750 people living with HIV in Botswana stop smoking. The program combines counseling, a referral system, and a medication called varenicline. Researchers will also see if training local staff to deliver this program is effective and affordable.

This study tests a new way to help people with HIV who are not yet virally suppressed. Researchers will use data reports to guide support programs in offering extra help. About 1,500 participants from low-income areas in New York City will take part. The goal is to see if this ap…

This study tests whether a combination of two experimental vaccines and three powerful antibodies can help people with HIV control the virus without needing daily antiretroviral therapy. About 36 adults with well-controlled HIV will receive the vaccines and antibodies, then tempo…

This study tests whether a two-drug HIV pill (dolutegravir/lamivudine) works as well as a three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults who have never taken HIV medication before. About 473 participants will take one of the two pills daily for up to…

This study tests whether getting the long-acting HIV prevention shot lenacapavir at a community pharmacy works well. About 75 HIV-negative adults will receive the shot every 6 months at the pharmacy. Researchers will track how many people stay on the prevention plan and whether f…

This study tests a program called Tu'Washindi, designed with input from young people, to help Kenyan girls and young women (ages 15-24) reduce intimate partner violence and increase use of PrEP, a daily pill that prevents HIV. About 1,562 participants will either receive the 6-mo…

This study looks at whether sending HIV self-test kits to men who have sex with men on a subscription basis encourages them to test regularly. 240 participants in Hong Kong will be observed for one year, comparing periods with and without the kit delivery. The goal is to increase…

This study tests a digital health platform called HMP designed for young sexual and gender minority (SGM) individuals. Researchers want to see if using the app helps more people start HIV prevention medication (PrEP) and achieve viral suppression if they have HIV. The study will …

This study tests an online program called PATHS that teaches parents how to talk to their gay or bisexual teenage sons about sexual health. About 393 parent-teen pairs take part, with teens aged 14-19. The goal is to see if the program helps teens feel more confident using condom…

This study tests two simple ways to help emergency department patients at risk for HIV start taking PrEP, a daily pill that prevents HIV. About 1,560 adults visiting the ER for sexual health concerns will be offered one of two low-burden strategies to get PrEP. The goal is to see…

This study tests whether delivering HIV prevention medication (PrEP) directly in communities is better than requiring clinic visits. About 2,500 young people in South Africa will receive PrEP either at a clinic or through a community-based service. The goal is to see if community…

This study works with primary care and reproductive health clinics to make it easier for women who inject drugs to get PrEP, a daily pill that prevents HIV. Researchers are testing a coaching program for clinic staff to see if it helps more women get screened and prescribed PrEP.…

This study tests two counseling programs to help women who use drugs in Tanzania start and continue taking PrEP, a daily pill that prevents HIV. 200 women will be randomly assigned to receive either basic information, two counseling sessions, or up to 14 sessions that also addres…

This study follows 100 cisgender women in the southern U.S. who are already using a long-acting injectable medication (cabotegravir) to prevent HIV. Researchers want to see how many women keep up with their shots over 44 weeks and how satisfied they are with the treatment. The go…

This study aims to make HIV prevention medication (PrEP) more available to pregnant women and new mothers in Kenyan health clinics. Researchers will train healthcare workers and improve clinic processes to reach up to 17,000 women. The goal is to reduce new HIV infections during …

This study looks at whether a single dose of the HPV vaccine can protect women living with HIV from getting new HPV infections. The researchers are comparing immediate vaccination versus a delayed dose in 778 women who have already received an HPV vaccine. The goal is to see if o…

This study tests a new program to help pregnant and breastfeeding women in South Africa take daily PrEP pills to prevent HIV. About 650 HIV-negative women will get either standard care or extra support like counseling and community pill delivery. The goal is to see if the program…

This study tests whether a smartphone game can help young people in Kenya learn about HIV and make safer choices. About 1,000 teens aged 12-17 will play the game and answer surveys. The goal is to see if the game delays first sex, increases condom use, and improves HIV knowledge.

This study tests whether a friendly chatbot on WhatsApp can help adults in Nigeria who are newly diagnosed with HIV learn more about the virus. About 314 people will either get standard care or also use the chatbot for information, reminders, and answers. The goal is to see if th…

This study looks at how to get a proven depression care service (HITIDES) into VA clinics that treat veterans with HIV. The service has been shown to work better than usual care and save money, but no VA clinic currently offers it. Researchers will compare two approaches to help …

This study looks at how effective the HPV vaccine is in women living with HIV and whether newer screening methods can catch cervical cancer earlier. About 810 women will use a self-sampling kit at home to test for high-risk HPV. Those who test positive will have a clinic visit wi…

This study looks at what services and support help people with HIV stay in treatment during their first six months on antiretroviral therapy (ART). About 771 adults in Zambia will share their preferences and needs through surveys. The goal is to design better care models that red…

This small, early-stage study tests whether spironolactone, a cheap and FDA-approved blood pressure pill, can reduce the hidden HIV reservoir in people on successful HIV treatment. Researchers will give the drug to 12 adults (some with HIV, some without) and measure its effects o…

This study looks at different ways to provide HIV treatment and care in Zambia, such as group visits or community pick-up points. Researchers will survey over 8,000 patients and staff at 12 clinics to see which methods work best for keeping patients healthy and satisfied. The goa…

This study tests whether adding stigma-reduction counseling to standard depression treatment helps adults living with HIV in Malawi. Researchers will enroll 200 people and measure if the approach is acceptable, feasible, and improves depression symptoms and HIV care engagement. T…

This study follows 830 women in Alabama who are at risk for HIV and sexually transmitted infections (STIs). Researchers want to learn what factors affect their risk and how often they use PrEP, a medicine that prevents HIV. Participants will not receive any treatment but will pro…

This study looks at whether a combination of two anti-HIV antibodies (bNAbs) can delay or lower the return of the virus after people stop their daily HIV medications. It involves 50 adults who previously received either the antibodies or a placebo in an earlier study. Participant…

This study looks at how well a long-acting HIV injection (CAB+RPV LA) works for people who live far from their doctor. About 55 patients and their clinic staff will share their experiences through surveys and interviews over 15 months. The goal is to understand what helps or make…

This study tests whether baricitinib, a drug used for arthritis, is safe and can reduce the hidden HIV reservoir in 30 people whose HIV is already well-controlled by standard medication. Participants take either baricitinib or a placebo daily for 12 weeks while continuing their r…

This study looks at why people with HIV are more likely to develop fatty liver disease. Researchers think changes in gut bacteria might be a cause. They will test if taking probiotics and prebiotic fiber can improve liver health in 63 participants with HIV and fatty liver.

This study looks at whether a computer-delivered alcohol intervention plus help from a community health worker can reduce heavy drinking and improve HIV prevention and care among women. About 12 women who drink heavily and either have HIV or are at risk for it will take part. The…

This study looks at how safe and effective a short, once-weekly treatment for latent tuberculosis (TB) is in children and teens with HIV who are taking the antiretroviral drug dolutegravir. The goal is to see if the TB drugs interact with the HIV medication and to check for side …

This study tests whether gentle reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors will be randomly assigned to receive different types of nudges or usual care. The goal …

This study tests a new way to screen for substance use disorders in people with HIV using an online patient portal, instead of only during clinic visits. The goal is to make screening easier and more accessible, especially for those who may face barriers. About 900 adults with HI…

This study aimed to see if changing the look and feel of HIV clinics in Uganda could reduce stigma and make patients feel more welcome. Researchers planned to update clinic systems and physical spaces to improve privacy and friendliness. The study was withdrawn before any partici…

This study aimed to test a new system that adds tiny, edible silica particles to HIV pills. People living with HIV could use a smartphone app to scan the pills and automatically record when they take their medication. The goal was to see if the system is easy to use and accuratel…

This study in Ghana tests a program to help caregivers tell children aged 7-18 about their HIV diagnosis. The goal is to see if this improves the children's health and medication habits. About 747 children and their caregivers are taking part across 12 clinics.

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers use a non-invasive ultrasound-like scan to measure liver fat and stiffness over one year. The goal is to fill major knowledge gaps, sinc…

This study looks at different ways clinics in South Africa provide HIV treatment and care. Researchers will survey over 15,000 patients and healthcare workers to understand how these models affect health outcomes, costs, and satisfaction. The goal is to help improve HIV services …

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with cancer symptoms or at risk will take part. Half the communities get the prog…

This study looks at different ways of providing HIV treatment and care in Malawi to see which methods work best for patients and clinics. Researchers are surveying over 15,000 patients and providers at 12 healthcare facilities. The goal is to help policymakers make better decisio…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will use a special ultrasound scan to measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to better understand this liver condition in people with HIV, …

This study is testing a new tool called PATH that helps doctors better care for older adults with HIV. The tool looks at common aging problems and suggests ways to manage them. Researchers want to see if it's practical and helpful for both patients and doctors. The study involves…

This study looks at whether using cannabis changes the amount of HIV medication in the blood and brain, and how it affects mood and thinking. Researchers will first observe 120 people who use cannabis regularly, then give cannabis or a placebo to 40 people to measure immediate ef…

This study compares two tests for latent tuberculosis (a hidden TB infection) in 200 people with HIV in Liberia. Participants receive a skin test and a blood test to see which one works better. The goal is to find the best way to screen for TB in this high-risk group.

This study looks at how cannabis, specifically a drug called Dronabinol, changes the immune system in people with HIV. Researchers will take blood samples before and after giving Dronabinol to see how genes and immune cells react. The goal is to better understand these effects, w…

This study looks at how HIV might disrupt the body's natural daily rhythms (circadian clock), which could lead to health issues like diabetes and heart disease. Researchers will track gene activity at different times of day in 80 people with and without HIV. The goal is to unders…

This study looks at whether the amount of HIV virus in people taking anti-HIV drugs for a long time stays the same or changes. It also checks if the virus develops new genetic changes while being suppressed. About 70 adults with HIV who have very low virus levels will join this 5…

This study asks 1098 adults in South Africa who have recently started HIV treatment what services would help them stay in care. Many patients drop out in the first six months, so researchers want to design better support. The study does not test a new drug or cure, but gathers in…

This study looks at 40 people with HIV to see if different types of HIV medications affect the hidden virus (the HIV reservoir) and immune system differently. Researchers want to know if a drug called tenofovir might cause more immune activation and keep the virus hiding longer. …

This study follows 127 people with HIV-related Kaposi sarcoma in Malawi and South Africa who are receiving standard chemotherapy. Researchers want to understand why some patients respond better than others, especially based on gender and virus levels. The goal is to find ways to …

This study will enroll 174 adults in New York City to see how well the mpox vaccine works in people with HIV compared to those without HIV. Researchers will test two ways of giving the vaccine: a low-dose shot in the forearm and a standard-dose shot in the upper arm. The goal is …