HIV

This is an early-stage study to check the safety and immune response of a new experimental HIV vaccine in healthy adults who do not have HIV. Researchers will give the vaccine candidate, which uses a protein from the HIV virus combined with an immune-boosting particle, to 57 volu…

This is a very early, first-in-human study to check if a new two-part HIV vaccine is safe and can trigger an immune response. It involves 36 healthy adults without HIV. Volunteers receive a shot of a nanoparticle-based vaccine followed later by a booster shot using mRNA technolog…

This study is testing a new support program led by pharmacists to help women with HIV who face social challenges like housing or food insecurity. The program uses telehealth to help these women switch from daily pills to a long-acting injectable HIV medication and stay on track w…

This study is testing whether a program that helps HIV-positive youth save money and build economic skills can improve their ability to take their daily HIV medication consistently. It involves 702 adolescents aged 10-16 in Uganda who are already on HIV treatment. The goal is to …

This study is testing two different ways to help VA clinics start using a proven team-based service for managing depression in Veterans who are living with HIV. The service has been shown to improve depression symptoms and save money, but it's not yet available. Researchers are c…

This trial is testing whether a new combination of four drugs taken for 12 weeks can work as well as the standard 26-week treatment for drug-susceptible tuberculosis. It will involve 94 adults with active lung TB, some of whom also have HIV. The main goal is to see if the shorter…

This study aims to understand and treat a rare, often fatal disorder called KSHV-associated multicentric Castleman's disease, which is caused by a virus and linked to certain cancers. Researchers are testing several experimental drug combinations in 75 adult participants to see i…

This study is testing a combination of an experimental HIV vaccine and lab-made antibodies in people who already have HIV and are taking daily medication. The goal is to see if this combination can help the body control the virus on its own, allowing participants to safely take a…

This study is testing whether a structured program to help caregivers tell children (ages 7-18) their HIV status leads to better health. It involves 720 child-caregiver pairs across 12 clinics in Ghana. Researchers will compare health outcomes, medication adherence, and costs bet…

This study aims to find the best COVID-19 booster strategy for people with weakened immune systems, such as those with HIV, organ transplants, or certain cancers. It will compare giving one versus two extra doses of approved mRNA vaccines to see which is safer and builds stronger…

This study is testing a new program called ENHANCE-TTS that trains and supports pharmacists to provide tobacco treatment. It aims to help people living with HIV quit smoking, as this group has high smoking rates. The research will measure how well pharmacists adopt the program an…

This study is testing whether a common antibiotic, doxycycline, can slow down the worsening of emphysema in people living with HIV. About 133 participants with both HIV and emphysema will take either doxycycline or a placebo pill twice daily for 72 weeks. Researchers will measure…

This study tests whether simple text message reminders ('nudges') sent to doctors, patients, or both can help more people living with HIV get connected to proven quit-smoking programs. It compares four different approaches to see which is most effective at getting people referred…

This study is testing whether a mobile phone program can help women living with HIV better plan their families and reproductive health. The program sends automated text messages and allows for two-way communication with a counselor. Researchers want to see if this support helps w…

This early-stage study is testing whether genetically modified stem cells are safe and can take hold in people with HIV. Researchers collect a patient's own blood stem cells, modify them in a lab to potentially resist HIV, and then return them after mild chemotherapy. The goal is…

This study is testing whether assigning a dedicated nurse case manager to patients improves treatment success for people with hard-to-treat, drug-resistant tuberculosis (MDR-TB), many of whom also have HIV. In South African hospitals, half will use these nurses to coordinate care…

This large, late-stage trial is testing two different support packages to help young children survive and regain health after being hospitalized for life-threatening severe malnutrition. It compares standard care against adding either a 12-week course of preventive antibiotics or…

This study aimed to see if changing the physical layout and systems of HIV clinics in Uganda could make them more private and welcoming. The goal was to reduce the stigma around HIV and help patients stay connected to their care. The study was withdrawn before any participants we…

This study is testing whether a cancer drug called N-803 (also known as IL-15) can help people with HIV control the virus without needing daily medication. Researchers want to see if stimulating the immune system can change how HIV hides in the body, potentially allowing people t…

This study aims to quickly identify HIV in newborns at high risk by testing them right after birth at the hospital. If a baby tests positive, they are immediately offered a modern HIV medication called dolutegravir and followed for two years to see how well they do. The goal is t…

This study is testing whether a community program called Potlako+ can help people with possible cancer symptoms get diagnosed and treated faster. The program involves educating communities about cancer warning signs and providing patient navigators to guide people through the hea…

This study aims to find out if giving long-acting HIV medication injections at a patient's home is as practical and well-liked as giving them in a hospital clinic. It will involve 120 adults with well-controlled HIV who are switching to this injectable treatment. Researchers will…

This study is testing if a combination of two lab-made antibodies can help the body control HIV for a longer time after people temporarily stop their regular antiretroviral therapy (ART). It involves 50 people with HIV who were in a previous study where some received these antibo…

This study is testing whether a home-based walking program can help people living with HIV who drink alcohol reduce their drinking and become more physically active. 222 participants were randomly assigned to either receive coaching sessions to add walking to their routine or jus…

This study is testing a new support strategy within existing Ryan White HIV/AIDS care programs in New York City. It aims to help people who are receiving HIV care but whose virus is not fully suppressed. The approach uses health data to guide program staff in providing targeted s…

This study aims to determine if liver transplants from deceased donors who have HIV are safe for recipients who also have HIV. It will compare survival and complication rates between patients receiving HIV-positive donor livers and those receiving standard HIV-negative donor live…

This study is testing whether a program combining urban gardening and peer nutrition counseling can help people with HIV who struggle with food insecurity. It aims to see if this approach improves their ability to stick with HIV medication and keep the virus under control. The tr…

This study tests whether using an online patient portal can improve screening for substance use disorders among people living with HIV. Researchers are comparing portal-based screening to usual clinic-based methods to see which approach reaches more patients and leads to better t…

This study is testing whether a special nutritional supplement can help babies who were exposed to HIV in the womb but are not infected. These babies often face more infections and slower growth. Researchers in South Africa are giving some babies a supplement containing prebiotic…

This study is testing if spironolactone, an existing blood pressure medication, can help control HIV by silencing the virus that hides in the body. It will enroll 12 adults, including some without HIV and some with well-controlled HIV on medication. Researchers will see if the dr…

This study compares three different treatment approaches for people with early HIV infection: AZT alone, interferon alone, or both drugs combined. Researchers followed 180 participants for decades to see which approach best controls the virus, preserves immune function, and delay…

This study is testing if switching to a simpler, two-drug HIV pill works as well as a three-drug pill for keeping the virus suppressed. It involves 205 people living with HIV who are 50 or older and have had their virus under control for at least a year. The main goal is to see i…

This study aims to find the most effective combination of support methods to help young people with HIV in Uganda stay on their medication and achieve viral suppression. Researchers are testing four different components—financial training, savings accounts, educational cartoons, …

This large Phase 3 trial is testing whether adding higher doses of two antibiotics (rifampicin and levofloxacin) for 14 days, with or without steroids, improves survival for adults hospitalized with severe, widespread tuberculosis and HIV. Researchers believe these intensified tr…

This early-stage study is testing a new approach to treating HIV. Researchers collect a patient's own immune cells, genetically modify them to better target HIV, and then infuse them back into the body. The main goals are to check if this process is safe and to see if the modifie…

This study compares two daily pill regimens for adults with HIV who are starting treatment for the first time. It tests whether a simpler two-drug combination works as well as a standard three-drug combination at keeping the virus under control. Researchers will also check for si…

This study is testing two different support programs to help teenagers with HIV in South Africa successfully move from pediatric to adult healthcare. It compares in-person support groups to a mobile phone-based program, aiming to see which helps teens stay on their medication and…

This study is testing if starting powerful HIV medication within the first week of life can limit how much of the virus takes hold in a baby's body. The goal is to see if this early treatment could allow children to safely take breaks from medication in the future without the vir…

This study is testing if a drug called baricitinib, used for rheumatoid arthritis, is safe and can reduce the hidden, inactive HIV that persists in the body even with effective treatment. It involves 30 adults with well-controlled HIV who will take either the drug or a placebo pi…

This study is testing a new support program for women who drink heavily and are at risk for or living with HIV. The program combines a computer-based session with help from a trained community health worker. Researchers want to see if this approach helps women drink less and bett…

This study is testing a program to help people living with HIV in Botswana quit smoking. It combines counseling support with a quit-smoking medication called varenicline. The goal is to reduce the serious health risks smoking adds to HIV and see if this approach can work well in …

This study is testing two different strategies to help more people start taking medication that prevents HIV. It focuses on patients visiting emergency rooms for sexual health concerns in communities heavily affected by HIV. One strategy offers a telehealth visit with a sexual he…

This study is testing an online program called PATHS, designed to help parents of gay and bisexual teenage boys (ages 14-19) have better conversations about sexual health. The goal is to see if improving parent communication can help reduce the teens' risk of getting HIV. Researc…

This study is testing whether a single dose of the HPV vaccine can prevent new HPV infections in women who are living with HIV and have already received HPV vaccination in the past. Researchers are comparing giving the HPV vaccine immediately versus after an 18-month delay in 778…

This study is checking if a weekly tuberculosis (TB) prevention treatment is safe and works well for children and teens who are living with HIV. Researchers want to see how this weekly treatment interacts with the modern HIV medications the participants are taking. The goal is to…

This large study aims to help more pregnant and postpartum women in Kenya start and stay on medication to prevent HIV. It tests a support program for health clinics, including training and quality improvement, to make offering this prevention a regular part of maternal care. The …

This study is testing a new support program to help pregnant and breastfeeding women in South Africa consistently take a daily pill that prevents HIV. The program offers easier access to the medication and extra counseling, especially for women who struggle to take it regularly. …

This study is testing whether a smartphone game can help prevent HIV among adolescents in Kenya. About 900 teens aged 12-14 will receive phones with either an educational HIV prevention game or a regular game to compare outcomes. The goal is to see if playing the game increases k…

This study is testing if a subscription service that mails free HIV self-test kits makes men who have sex with men (MSM) more likely to get tested regularly. Over 240 participants in Hong Kong will first get text reminders to get tested, then later receive the mailed test kits. R…

This study aims to help primary care and reproductive health clinics better provide HIV prevention medication (PrEP) to women who inject drugs. Researchers will work with clinics, providers, and the women themselves to understand and overcome barriers to care. The goal is to desi…

This study is testing whether delivering HIV prevention medication (PrEP) directly to people in their communities is more effective than requiring them to visit clinics. It involves 2,500 young women and men in South Africa who are at high risk for HIV. The goal is to see if this…

This study is observing 100 women in the Southern U.S. who are using a long-acting injection called Cabotegravir (CAB-LA) to prevent HIV. Researchers will track how well women stick with the injection schedule over two years and monitor their health outcomes. The goal is to under…

This study is creating and testing a new program designed to help Latino men who have sex with men in Miami get better access to HIV prevention tools and mental health support. The program aims to connect 90 eligible participants to services like PrEP (a daily pill that prevents …

This study is testing a program called Tu'Washindi, designed by young people, to help adolescent girls and young women in Kenya. The goal is to see if the program can help them take a daily pill to prevent HIV more consistently and reduce violence from their intimate partners. Th…

This study is testing a new counseling program designed to reduce the stigma surrounding HIV and mental illness. It will involve 200 adults in Malawi who are living with HIV and experiencing depression. The goal is to see if adding stigma-reduction counseling to standard depressi…

This pilot study is testing a new geriatric assessment and management tool designed for older adults living with HIV. The research aims to see if this tailored approach is practical and acceptable for use in HIV clinics and if it can help improve patients' quality of life. The st…

This study is testing whether a combination of two drugs, dasatinib and quercetin, can improve physical function in older adults with HIV who are experiencing frailty or early signs of frailty. The trial involves 82 participants aged 50+ who have had HIV for at least 10 years and…

This study is testing whether adding prize incentives to standard job-search help makes it easier for people living with HIV to find employment. It involves 144 unemployed adults with HIV who want to work. One group gets standard support, while another gets the same support plus …

This study aims to understand how using cannabis affects the levels of HIV medications in the body and brain, and whether it impacts mood and thinking. Researchers will first observe 120 people who already use cannabis, then give cannabis or a placebo to 40 people to measure imme…

This study aims to understand what services and support HIV patients in South Africa prefer during their first six months on antiretroviral therapy. Researchers are surveying over 1,000 adults who recently started or restarted treatment at 18 healthcare facilities. The goal is to…

This study aims to understand why some women in Alabama get sexually transmitted infections (STIs) or HIV, and what influences their use of prevention medications. Researchers will follow 830 women who identify as cisgender or transgender and are at risk for HIV, using a smartpho…

This study is testing whether a chatbot on WhatsApp can help adults in Nigeria who are newly diagnosed with HIV. The chatbot provides information, answers questions, and sends reminders for appointments and medication. Researchers want to see if using the chatbot improves people'…

This study is observing how different ways of delivering HIV care affect patients, healthcare workers, and costs in South Africa, Malawi, and Zambia. It surveys thousands of patients and providers and tracks clinic resources to understand which care models work best. The goal is …

This study aims to understand how common fatty liver disease is in people living with HIV. Researchers will enroll 1,250 participants to measure liver fat and collect health information. The goal is to identify risk factors and fill a major knowledge gap, as previous large studie…

This study observes how HIV-related Kaposi Sarcoma, a type of cancer, responds to standard chemotherapy treatments given in Malawi and South Africa. It follows 127 adult patients already receiving standard care to understand why outcomes vary and identify markers that could predi…

This study is gathering information to help improve how HIV treatment is delivered in Malawi. Researchers are surveying patients and healthcare workers, and observing clinic operations at 12 facilities to compare different care models. The goal is to understand which approaches w…

This study aims to find the most effective way to screen for hidden (latent) tuberculosis in people living with HIV in Liberia. Researchers are comparing two different skin tests to see which one works better in this setting. The study involves 200 adult participants who are alre…

This study aims to see if measuring a medication's level in a simple dried blood spot can help predict whether a person's HIV will stay under control. Researchers will follow 384 adults with HIV who are already taking a specific medication (TAF) for 48 weeks. The goal is to learn…

This study aims to understand how well a lower-dose mpox vaccine works and how safe it is for people living with HIV, compared to people without HIV and to the standard vaccine dose. Researchers will measure immune responses and track side effects in 174 participants who have rec…

This study aims to understand what services and support people living with HIV in Zambia prefer during their first six months on medication. Researchers are surveying over 770 adults who recently started or restarted treatment at 12 healthcare facilities. The goal is to use this …

This study is gathering information about different ways to deliver HIV treatment in Zambia. Researchers are surveying patients and healthcare workers at 12 clinics to understand how various care models affect treatment success, clinic efficiency, and costs. The goal is to provid…

This study aims to understand if disruptions to the body's natural daily rhythms (circadian clock) help explain why people with HIV often develop other health problems like heart disease or diabetes. Researchers will track 80 men's daily patterns—including sleep, activity, light …

This early-stage study aims to understand how a cannabis-based medication (Dronabinol) affects the immune system and genes in people living with HIV. Researchers will compare 160 participants, both with and without HIV, who have used cannabis before. The goal is to gather basic k…

This study aims to understand how HIV behaves in people who have been taking antiviral medications for many years. Researchers will follow 70 HIV-positive adults for at least 5 years to see if the virus level continues to decrease or stays stable, and whether new genetic changes …

This study aims to understand how fatty liver disease develops and progresses in people living with HIV. Researchers will follow 400 participants for at least one year, using non-invasive scans to measure liver fat and stiffness. The goal is to fill critical knowledge gaps about …